scholarly journals Genetically Predicted Cardiac Troponin I Concentrations and Risk of Stroke and Atrial Fibrillation

2022 ◽  
Vol 31 (3) ◽  
pp. 106267
Author(s):  
Dandan Liu ◽  
Yue Deng ◽  
Jiao Wang ◽  
Yanan Chen ◽  
Jian Yu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I

Atrial fibrillation-induced cardiac troponin I release

2013 ◽  
Vol 168 (3) ◽  
pp. 2734-2737 ◽  
Author(s):  
Abdul Shokor Parwani ◽  
Leif-Hendrik Boldt ◽  
Martin Huemer ◽  
Alexander Wutzler ◽  
Daniela Blaschke ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I

Atrial fibrillation-induced cardiac troponin I release

2014 ◽  
Vol 172 (1) ◽  
pp. 220 ◽  
Author(s):  
Abdul S. Parwani ◽  
Leif-Hendrik Boldt
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I

scholarly journals Genetically Predicted Cardiac Troponin I Concentrations and Risk of Stroke and Atrial Fibrillation

2021 ◽  
Author(s):  
Dandan Liu ◽  
Yue Deng ◽  
Jiao Wang ◽  
Yanan Chen ◽  
Jian Yu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Intracerebral Hemorrhage ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Mendelian Randomization ◽  
Cardiac Troponin I ◽  
Cardioembolic Stroke ◽  
Large Artery ◽  
Increased Risk

Abstract Background: Observational studies have shown that elevated circulating cardiac troponin I (cTnI) concentrations were associated with higher risk of stroke and atrial fibrillation, but the causality remains unclear. Therefore, we conducted a two-sample mendelian randomization study to evaluate the causal effects of cTnI concentrations on the risk of stroke subtypes and atrial fibrillation.Methods: The instrumental variables for circulating cTnI concentrations were selected from a genome-wide association study meta-analysis of 48,115 European individuals. Applying a 2-sample mendelian randomization approach, we examined the associations of circulating cTnI concentrations with stroke (40,585 cases and 406,111 controls), ischemic stroke (34,217 cases and 406,111 controls), ischemic stroke subtypes (cardioembolic, large artery, small vessel stroke), intracerebral hemorrhage (1,545 cases and 1,481 controls) and atrial fibrillation (60,620 cases and 970,216 controls). Results: Genetically predicted elevated circulating cTnI concentrations were associated with increased risk of cardioembolic stroke (odds ratio [OR], 1.80; 95% confidence interval [CI], 1.20-2.68; P = 0.004). However, no significant association was observed for cTnI concentrations with large artery stroke, small vessel stroke, total stroke, ischemic stroke and intracerebral hemorrhage. Additionally, we also found that elevated cTnI concentrations were associated with higher risk of atrial fibrillation (OR, 1.30; 95% CI, 1.10-1.53; P = 0.003).Conclusions: This study provides evidence that genetically predicted circulating cTnI concentrations are causally associated with increased risk of cardioembolic stroke and atrial fibrillation.

scholarly journals Association of cardiac troponin I with prothrombotic alterations in atrial fibrillation

2018 ◽  
pp. 1106-1109 ◽  
Author(s):  
Paweł T. Matusik ◽  
Shannon M. Prior ◽  
Saulius Butenas ◽  
Barbara Małecka ◽  
Jacek Lelakowski ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I

scholarly journals High Cardiac Troponin I Is Associated With Transesophageal Echocardiographic Risk of Thromboembolism and Ischemic Stroke Events in Non-Valvular Atrial Fibrillation Patients

2018 ◽  
Vol 82 (6) ◽  
pp. 1699-1704 ◽  
Author(s):  
Shuhei Tanaka ◽  
Tadakazu Hirai ◽  
Kyoko Inao ◽  
Nobuyuki Fukuda ◽  
Keiko Nakagawa ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I

scholarly journals Cardiac troponin-I as a predictor of mortality in patients with first episode acute atrial fibrillation

QJM ◽  
2017 ◽  
Vol 110 (8) ◽  
pp. 507-511 ◽  
Author(s):  
M.E. Naffaa ◽  
R. Nasser ◽  
E. Manassa ◽  
M. Younis ◽  
Z.S. Azzam ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
First Episode
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