Comments on “Validation of a medium-frequency computational method for the coupling between a plate and a water-filled cavity”

2004 ◽  
Vol 276 (3-5) ◽  
pp. 1115-1116 ◽  
Author(s):  
P.A.A. Laura ◽  
S.A. Vera
Keyword(s):  
Computational Method ◽  
Medium Frequency

A multiscale computational method for medium-frequency vibrations of assemblies of heterogeneous plates

2003 ◽  
Vol 81 (12) ◽  
pp. 1267-1276 ◽  
Author(s):  
P. Ladevèze ◽  
L. Blanc ◽  
P. Rouch ◽  
C. Blanzé
Keyword(s):  
Computational Method ◽  
Medium Frequency

Medium-frequency acoustic methods and tools for the study of the aquatic environment.

2020 ◽  
Author(s):  
N.A. Grekov ◽  
◽  
A.N. Grekov ◽  
E.N. Sychov ◽  
◽  
...  
Keyword(s):  
Aquatic Environment ◽  
Medium Frequency ◽  
Acoustic Methods

MULTI-LEVEL K-d TREE-BASED DATA-DRIVEN COMPUTATIONAL METHOD FOR THE DYNAMIC ANALYSIS OF MULTI-MATERIAL STRUCTURES

2020 ◽  
Vol 18 (4) ◽  
pp. 421-438
Author(s):  
Zhangcheng Zheng ◽  
Hongfei Ye ◽  
Hongwu Zhang ◽  
Yonggang Zheng ◽  
Zhen Chen
Keyword(s):  
Dynamic Analysis ◽  
Computational Method ◽  
Data Driven ◽  
Multi Level

Aiming for a Standardized Protocol for Preparing a Process Green Synthesis Report and for Ranking Multiple Synthesis Plans to a Common Target Product

2019 ◽  
Author(s):  
john andraos
Keyword(s):  
Green Synthesis ◽  
Block Diagram ◽  
Computational Method ◽  
Borda Count ◽  
Target Product ◽  
Material Efficiency ◽  
Synthesis Report ◽  
Common Target ◽  
Greenness Index ◽  
Multiple Synthesis

This paper proposes a standardized format for the preparation of process green synthesis reports that can be applied to chemical syntheses of active pharmaceutical ingredients (APIs) of importance to the pharmaceutical industry. Such a report is comprised of the following eight sections: a synthesis scheme, a synthesis tree, radial pentagons and step E-factor breakdowns for each reaction step, a tabular summary of key material efficiency step and overall metrics for a synthesis plan, a mass process block diagram, an energy consumption audit based on heating and cooling reaction and auxiliary solvents, a summary of environmental and safety-hazard impacts based on organic solvent consumption using the Rowan solvent greenness index, and a cycle time process schedule. Illustrative examples of process green synthesis reports are given for the following pharmaceuticals: 5-HT2B and 5-HT7 receptors antagonist (Astellas Pharma), brivanib (Bristol-Myers Squibb), and orexin receptor agonist (Merck). Methods of ranking synthesis plans to a common target product are also discussed using 6 industrial synthesis plans of apixaban (Bristol-Myers Squibb) as a working example. The Borda count method is suggested as a facile and reliable computational method for ranking multiple synthesis plans to a common target product using the following 4 attributes obtained from a process green synthesis report: process mass intensity, mass of sacrificial reagents used per kg of product, input enthalpic energy for solvents, and Rowan solvent greenness index for organic solvents.<br>

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