The Ideological Legacy of Charles de Gaulle. I. Paradoxical Perception, Paradoxical Historical Memory, Paradoxical Political Philosophy

The personality of General de Gaulle, which once divided the French, now holds the first place in their national imagination. In recent years, all kinds of politicians have increasingly laid claim to his legacy. Ironically, the new reverence for de Gaulle has grown with the demise of Gaullism and intensified with French elites turning to an alternative Euro-Atlanticist and neoliberal paradigm. In this paradox, the “obsession with Gaulle” has taken on very different meanings. For some it is a rhetoric instrument or compensatory nostalgia, but for many it is indeed a symbol of disagreement with political dogma of the last decades. De Gaulle's shadow over today’s France is inextricably linked to the appeal and relevance of his ideas. His political philosophy stands out by a kind of multiple synthesis of opposites, often overlooked and underappreciated. De Gaulle's cornerstone ideas directly resonate with fundamental dilemmas that are now at the heart of controversies within societies and internationally, including those between West and Russia, West and East. His search for a dialectical conjunction of national, European and global imperatives is of particular interest.

Aiming for a Standardized Protocol for Preparing a Process Green Synthesis Report and for Ranking Multiple Synthesis Plans to a Common Target Product

This paper proposes a standardized format for the preparation of process green synthesis reports that can be applied to chemical syntheses of active pharmaceutical ingredients (APIs) of importance to the pharmaceutical industry. Such a report is comprised of the following eight sections: a synthesis scheme, a synthesis tree, radial pentagons and step E-factor breakdowns for each reaction step, a tabular summary of key material efficiency step and overall metrics for a synthesis plan, a mass process block diagram, an energy consumption audit based on heating and cooling reaction and auxiliary solvents, a summary of environmental and safety-hazard impacts based on organic solvent consumption using the Rowan solvent greenness index, and a cycle time process schedule. Illustrative examples of process green synthesis reports are given for the following pharmaceuticals: 5-HT2B and 5-HT7 receptors antagonist (Astellas Pharma), brivanib (Bristol-Myers Squibb), and orexin receptor agonist (Merck). Methods of ranking synthesis plans to a common target product are also discussed using 6 industrial synthesis plans of apixaban (Bristol-Myers Squibb) as a working example. The Borda count method is suggested as a facile and reliable computational method for ranking multiple synthesis plans to a common target product using the following 4 attributes obtained from a process green synthesis report: process mass intensity, mass of sacrificial reagents used per kg of product, input enthalpic energy for solvents, and Rowan solvent greenness index for organic solvents.<br>

Aiming for a Standardized Protocol for Preparing a Process Green Synthesis Report and for Ranking Multiple Synthesis Plans to a Common Target Product

This paper proposes a standardized format for the preparation of process green synthesis reports that can be applied to chemical syntheses of active pharmaceutical ingredients (APIs) of importance to the pharmaceutical industry. Such a report is comprised of the following eight sections: a synthesis scheme, a synthesis tree, radial pentagons and step E-factor breakdowns for each reaction step, a tabular summary of key material efficiency step and overall metrics for a synthesis plan, a mass process block diagram, an energy consumption audit based on heating and cooling reaction and auxiliary solvents, a summary of environmental and safety-hazard impacts based on organic solvent consumption using the Rowan solvent greenness index, and a cycle time process schedule. Illustrative examples of process green synthesis reports are given for the following pharmaceuticals: 5-HT2B and 5-HT7 receptors antagonist (Astellas Pharma), brivanib (Bristol-Myers Squibb), and orexin receptor agonist (Merck). Methods of ranking synthesis plans to a common target product are also discussed using 6 industrial synthesis plans of apixaban (Bristol-Myers Squibb) as a working example. The Borda count method is suggested as a facile and reliable computational method for ranking multiple synthesis plans to a common target product using the following 4 attributes obtained from a process green synthesis report: process mass intensity, mass of sacrificial reagents used per kg of product, input enthalpic energy for solvents, and Rowan solvent greenness index for organic solvents.<br>

Aiming for a standardized protocol for preparing a process green synthesis report and for ranking multiple synthesis plans to a common target product

This paper proposes a standardized format for the preparation of process green synthesis reports that can be applied to chemical syntheses of active pharmaceutical ingredients (APIs) of importance to the pharmaceutical industry. Such a report is comprised of the following eight sections: a synthesis scheme, a synthesis tree, radial pentagons and step E-factor breakdowns for each reaction step, a tabular summary of key material efficiency step and overall metrics for a synthesis plan, a mass process block diagram, an energy consumption audit based on heating and cooling reaction and auxiliary solvents, a summary of environmental and safety-hazard impacts based on organic solvent consumption using the Rowan solvent greenness index, and a cycle time process schedule. Illustrative examples of process green synthesis reports are given for the following pharmaceuticals: 5-HT2B and 5-HT7 receptors antagonist (Astellas Pharma), brivanib (Bristol-Myers Squibb), and orexin receptor agonist (Merck). Methods of ranking synthesis plans to a common target product are also discussed using 6 industrial synthesis plans of apixaban (Bristol-Myers Squibb) as a working example. The Borda count method is suggested as a facile and reliable computational method for ranking multiple synthesis plans to a common target product using the following 4 attributes obtained from a process green synthesis report: process mass intensity, mass of sacrificial reagents used per kg of product, input enthalpic energy for solvents, and Rowan solvent greenness index for organic solvents.

Synthesis of LC-Oscillators Using Rival Multi-Objective Multi-Constraint Optimization Kernels

This chapter presents a state-of-the-art multi-objective/multi-constraint design automation approach applied to the design of an LC-Voltage Controlled Oscillator and an LC-Oscillator for a 130 nm technology node and leading to sets of design solutions showing figures-of-merit around -192 dBc/Hz and -186 dBc/Hz, respectively. The proposed approach, implemented in AIDA-C, guarantees accuracy by using commercial circuit simulators (HSPICE® and ELDO®) to evaluate the performance of the tentative circuit solutions, where the number of time-consuming circuit simulations is efficiently pruned by the optimization kernel. Three multi-objective optimization algorithms, the NSGA-II, the MOPSO, and the MOSA, are experimented with in the synthesis of the quoted oscillators and compared in terms of performance using statistical results obtained from multiple synthesis runs for each one of the oscillators. The performance of the optimized oscillators is then compared to other state-of-the-art results, showing the benefits of the presented multi-objective design approach.