EP1.01-54 Implementation of Fine Needle Aspiration of Supraclavicular Lymph Node as a Novel Medium for Genomic Profiling in NSCLC

Background: Fine needle aspiration cytology as a first line of investigation has assumed importance in diagnosing a variety of disease process. The aim of this study was to assess the diagnostic value of fine needle aspiration cytology in the evaluation of palpable supraclavicular lymph nodes. Materials and methods: This was a retrospective study of fine needle aspiration cytology of palpable supraclavicular lymph node done between January 1, 2007 and December 31, 2009. Fine needle aspiration cytology was performed on 149 patients (49 cases at Om Hospital & Research Centre and 100 cases at Tribhuvan University Teaching Hospital). Results: The right supraclavicular lymph node was enlarged in 55% cases, while the left supraclavicular lymph node alone was palpable in 40.3% cases and in 7 of 149 (4.7%) cases, bilateral supraclavicular lymph nodes were palpable. Cytological diagnoses were categorized as reactive (8.7%), tuberculosis (41.6%), lymphoma (4.8%) and metastasis (44.9%). Of a total of 74 cases of malignancy, 90.5% were non-lymphoid and 9.5% were lymphoid (5 Non-Hodgkin lymphoma and 2 Hodgkin lymphoma). Of the 67 cases of metastatic disease, three major types of malignancy found in supraclavicular lymph nodes were Squamous cell carcinoma (28 cases), adenocarcinoma (21 cases) and others (small cell carcinoma, papillary thyroid carcinoma etc). Adenocarcinoma tended to metastasize to the left supraclavicular lymph node. Lung was the most common primary site (43.3%), followed by stomach, ovary, breast and larynx. However, in 28.4% cases, no primary site was found. Conclusion: The fine needle aspiration cytology can be used as a first line investigation in the evaluation of supraclavicular lymphadenopathy due to its low cost, simplicity and minimal invasiveness. Keywords: Supraclavicular lymph node; Fine needle aspiration cytology; Metastasis DOI: 10.3126/jpn.v1i1.4441 Journal of Pathology of Nepal (2011) Vol.1, 8-12

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Ultrasound guided fine needle aspiration cytology diagnosis of collision tumor in a lymph node: Lymphoma and metastatic adenocarcinoma

Case Reports in Clinical Pathology ◽

10.5430/crcp.v4n2p1 ◽

2017 ◽

Vol 4 (2) ◽

pp. 1

Author(s):

Qian Wang ◽

Dhanalaksmi Balakrishnan ◽

Maoxin Wu

Keyword(s):

Lymph Node ◽

Lung Adenocarcinoma ◽

Fine Needle Aspiration ◽

Flow Cytometric Analysis ◽

Needle Aspiration ◽

Lymphocytic Leukemia ◽

Ultrasound Guided ◽

Supraclavicular Lymph Node ◽

Fine Needle ◽

Metastatic Lung

Diagnosis of two distinct malignancies in a single sample is rare. Here we report a case of lung adenocarcinoma metastasized to a supraclavicular lymph node which was concomitantly diagnosed with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) using ultrasound-guided fine needle aspiration biopsy (US-FNA) sample.A 62-year-old Caucasian male presented with cough and bloody sputum. US-FNA of a supraclavicular lymph node showed two distinct cell populations and, based on morphological examination and immunohistochemical staining of the FNA cell block slides, diagnosed with CLL/SLL and metastatic lung adenocarcinoma. Flow cytometric analysis of peripheral blood supported the diagnosis of CLL/SLL. To our knowledge, this is a rarely reported cytology case in which metastatic lung adenocarcinoma is concurrently diagnosed with CLL/SLL in a single lymph node and can be diagnosed based an FNA sample.

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