scholarly journals P85.06 Clinical and Genomic Features of Middle Intensity cMET Stain of Chinese Lung Cancer Patients

2021 ◽  
Vol 16 (3) ◽  
pp. S671
Author(s):  
X. Dong ◽  
J. Zhao ◽  
D. Gu ◽  
R. Chen ◽  
X. Xia
2019 ◽  
Vol 14 (10) ◽  
pp. S304-S305
Author(s):  
W. Peng ◽  
J. Li ◽  
L. Chang ◽  
J. Bai ◽  
Y. Zhang ◽  
...  

2020 ◽  
Author(s):  
Shuiping Dai ◽  
Pengwei Ren ◽  
Jing Ren ◽  
Lan Yang ◽  
Weimin Li

Abstract Background It has been shown that the prognosis of malignant tumors was closely related to the composition and function of immune system, which was associated with genomic features. However, the prognostic value of peripheral T lymphocyte subsets and its relationship with genomic features in lung cancer has not been analyzed extensively. Therefore, this study was intended to evaluate the relationship between lymphocyte subsets and the prognosis and genomic features of lung cancer. Methods 598 lung cancer patients with complete data were included in this study between 2011 and 2018. Kaplan-Meier method and Pearson analyses were conducted to study the prognostic value of CD3+, CD4+, CD8 + T lymphocytes and the rate of CD4/CD8. Results Patients with EGFR mutation has lower percentage of CD8 + lymphocytes than patients with EGFR wild-type (24.71 versus 26.62, respectively, P = 0.041). Patients with high CD3 + had better OS than those with low (27 versus 14 months, P = 0.002). OS of higher CD4 + and CD4/CD8 rate had longer OS than of lower (27 versus 12 months, P = 0.002; 25 versus 9 months, P = 0.008, respectively). Patients with high CD8 + had poor PFS than low group (6 versus 11 months, P = 0.009). There was a negative correlation between CD3 + and CD4 + cells and OS in smoking stage 2 female lung cancer patients (PCC = 0.626, P < 0.05; PCC = 0.534, P < 0.05, respectively). In stage 1 male lung cancer patients, CD8 + T cell is negatively correlated with OS and PFS (PCC = 0.295, P < 0.05; PCC = 0.280, P < 0.05, respectively) Conclusions Lung cancer patients with EGFR mutation had lower percentage of CD8 + lymphocytes. Lymphocyte subsets might be potential prognostic biomarkers of lung cancer, but they are affected by gender and tumor stage.


2004 ◽  
Vol 66 (6) ◽  
pp. 602-607 ◽  
Author(s):  
Miho UCHIHIRA ◽  
Takahiro EJIMA ◽  
Takao UCHIHIRA ◽  
Jun ARAKI ◽  
Toshiaki KAMEI

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