Aim and Objective:
Lung cancer is a highly heterogeneous cancer, due to the significant
differences in molecular levels, resulting in different clinical manifestations of lung cancer patients
there is a big difference. Including disease characterization, drug response, the risk of recurrence,
survival, etc.
Method:
Clinical patients with lung cancer do not have yet particularly effective treatment options,
while patients with lung cancer resistance not only delayed the treatment cycle but also caused strong
side effects. Therefore, if we can sum up the abnormalities of functional level from the molecular
level, we can scientifically and effectively evaluate the patients' sensitivity to treatment and make the
personalized treatment strategies to avoid the side effects caused by over-treatment and improve the
prognosis.
Result & Conclusion:
According to the different sensitivities of lung cancer patients to drug
response, this study screened out genes that were significantly associated with drug resistance. The
bayes model was used to assess patient resistance.