Cutaneous Side Effects in 19 Lung Cancer Patients Treated with Gefitinib (Iressa)

Aim and Objective: Lung cancer is a highly heterogeneous cancer, due to the significant differences in molecular levels, resulting in different clinical manifestations of lung cancer patients there is a big difference. Including disease characterization, drug response, the risk of recurrence, survival, etc. Method: Clinical patients with lung cancer do not have yet particularly effective treatment options, while patients with lung cancer resistance not only delayed the treatment cycle but also caused strong side effects. Therefore, if we can sum up the abnormalities of functional level from the molecular level, we can scientifically and effectively evaluate the patients' sensitivity to treatment and make the personalized treatment strategies to avoid the side effects caused by over-treatment and improve the prognosis. Result & Conclusion: According to the different sensitivities of lung cancer patients to drug response, this study screened out genes that were significantly associated with drug resistance. The bayes model was used to assess patient resistance.

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P3.17-03 Survival and Side Effects in Non-Small Cell Lung Cancer Patients Treated with Combination of Chemotherapy and Conformal Radiotherapy

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2018.08.1958 ◽

2018 ◽

Vol 13 (10) ◽

pp. S1021

Author(s):

S. Crvenkova

Keyword(s):

Lung Cancer ◽

Side Effects ◽

Small Cell Lung Cancer ◽

Cancer Patients ◽

Cell Lung Cancer ◽

Conformal Radiotherapy ◽

Small Cell ◽

Small Cell Lung ◽

Lung Cancer Patients

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Pol ζ polymorphisms are associated with platinum based chemotherapy response and side effects among non-small cell lung cancer patients

Neoplasma ◽

10.4149/neo_2015_101 ◽

2015 ◽

Vol 62 (05) ◽

pp. 833-839 ◽

Cited By ~ 6

Author(s):

J. YE ◽

T. CHU ◽

R. LI ◽

Y. NIU ◽

B. JIN ◽

...

Keyword(s):

Lung Cancer ◽

Side Effects ◽

Small Cell Lung Cancer ◽

Cancer Patients ◽

Cell Lung Cancer ◽

Small Cell ◽

Chemotherapy Response ◽

Small Cell Lung ◽

Lung Cancer Patients ◽

Platinum Based Chemotherapy

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The Effects of Acupressure on Meridian Energy as well as Nausea and Vomiting in Lung Cancer Patients Receiving Chemotherapy

Biological Research For Nursing ◽

10.1177/1099800416683801 ◽

2016 ◽

Vol 19 (2) ◽

pp. 145-152 ◽

Cited By ~ 1

Author(s):

Chi-Hsiang Shen ◽

Li-Yu Yang

Keyword(s):

Lung Cancer ◽

Side Effects ◽

Cancer Patients ◽

Nausea And Vomiting ◽

Control Group ◽

Lung Cancer Patients ◽

Clinical Nurses ◽

Quasi Experimental ◽

The Mean ◽

Experimental Group

Nausea and vomiting are the most common side effects of antineoplastic chemotherapy. However, only a small number of studies have been conducted in Taiwan to determine the efficacy of acupressure in treating these side effects in cancer patients receiving chemotherapy. In this quasi-experimental study, we aimed to explore the effects of acupressure on meridian energy as well as nausea and vomiting in 70 lung cancer patients receiving chemotherapy. Patients were assigned to the experimental or control group based on order of hospital admission. The experimental group received acupressure on “Neiguan (PC6)” and “Gongsun (SP4)” points, and the control group received sham acupoint patches on “Houxi (SI3)” point. The results showed that the mean meridian energy in the experimental group after acupressure was significantly higher than in the control group ( F = 28.71, p < .001). The experimental group had significantly less nausea ( p < .001) and vomiting ( p = .006) during the delayed phase than the control group. In conclusion, acupressure significantly increased the mean meridian energy and effectively decreased the severity of nausea and vomiting in lung cancer patients undergoing chemotherapy. We recommend that clinical nurses provide acupressure as an intervention to relieve nausea and vomiting in patients receiving chemotherapy.

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Vascular Acrosyndromes Associated With Prolonged Tumor Response in Advanced Lung Cancer Patients During Treatment With Antimetabolites: A Report of Two Cases

Frontiers in Oncology ◽

10.3389/fonc.2021.644282 ◽

2021 ◽

Vol 11 ◽

Author(s):

Margaux Geier ◽

Hélène Babey ◽

Lucie Monceau-Baroux ◽

Gilles Quéré ◽

Renaud Descourt ◽

...

Keyword(s):

Lung Cancer ◽

Side Effects ◽

Cancer Patients ◽

Tumor Response ◽

Checkpoint Inhibitors ◽

Advanced Lung Cancer ◽

Tumor Control ◽

Lung Cancer Patients ◽

Digital Ischemia ◽

Nsclc Patients

BackgroundPemetrexed and gemcitabine are both antimetabolites drugs approved in advanced non-small cell lung cancer (NSCLC). Their toxicity profile is well known. However, rare vascular side effects can occur such as vascular acrosyndromes and especially digital ischemia. The cause of this disfiguring and painful event is still controversial. Amputation is frequently required and has been described as a predictor of poor survival outcomes.Case PresentationThis report presents two cases of vascular acrosyndrome in NSCLC patients during treatment with antimetabolites (pemetrexed and gemcitabine). Patients presented severe digital ischemia having required prostacyclin analog and chemotherapy discontinuation. In one case, symptoms improved while in the other case symptoms persisted. Both patients experienced prolonged tumor response. These findings suggest a multifactorial mechanism behind digital necrosis including an autoimmune process, which could lead to prolonged tumor control as described with immune checkpoint inhibitors.ConclusionSevere vascular acrosyndrome such as digital ischemia can occur in lung cancer patients treated with antimetabolites. Awareness needs to be raised when using these drugs in patients with predisposing factors. Whether occurrence of chemotherapy-induced immune vascular side effects might explain prolonged tumor response deserves further investigations.

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