311 ELUCIDATING MECHANISMS OF SUNITINIB RESISTANCE IN METASTATIC RENAL CELL CARCINOMA BY STUDYING ITS EFFECT ON MYELOID DERIVED SUPPRESSOR CELLS (MDSC) IN MURINE TUMOR MODELS

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Kevin Chandler ◽  
Charles Tannenbaum ◽  
James Finke
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Tumor Models ◽  
Murine Tumor

scholarly journals Arginase I–Producing Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma Are a Subpopulation of Activated Granulocytes

2009 ◽  
Vol 69 (4) ◽  
pp. 1553-1560 ◽  
Author(s):  
Paulo C. Rodriguez ◽  
Marc S. Ernstoff ◽  
Claudia Hernandez ◽  
Michael Atkins ◽  
Jovanny Zabaleta ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Arginase I

scholarly journals HMGB1 promotes myeloid-derived suppressor cells and renal cell carcinoma immune escape

Oncotarget ◽  
2017 ◽  
Vol 8 (38) ◽  
pp. 63290-63298 ◽  
Author(s):  
Jinfeng Li ◽  
Jiajia Sun ◽  
Ruiming Rong ◽  
Long Li ◽  
Wenjun Shang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Immune Escape ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

scholarly journals IMPACT OF ENDOSTATIN GENE THERAPY ON MYELOID-DERIVED SUPPRESSOR CELLS FROM A METASTATIC RENAL CELL CARCINOMA

2018 ◽  
Vol 40 (1) ◽  
pp. 24-32
Author(s):  
K CB Chaves ◽  
E M Costa ◽  
L F Teixeira ◽  
M H Bellini
Keyword(s):  
Gene Therapy ◽  
Renal Cell Carcinoma ◽  
Flow Cytometry ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells ◽  
Metastatic Progression

Aim: To evaluate the role of endostatin (ES) gene therapy on myeloid-derived suppressor cells (MDSC) in a metastatic model of renal cell carcinoma (RCC). Materials and Methods: Balb/C mice bearing orthotopic Renca tumors were treated with NIH/3T3LendSN or, as a control, with NIH/3T3-LXSN cells. At the end of in vivo experiment, plasma and tissue lung samples were collected. Plasma ES and granulocyte colony stimulating factor (G-CSF) levels were measured by ELISA and Milliplex, respectively. Quantification of CD11b+Gr-1+ cells and their subsets was performed by flow cytometry. Reactive oxygen species (ROS) production was measured in CD11b+Gr-1+ MDSC using the DCFDA marker by flow cytometry. Results: Metastatic RCC (mRCC) induced expansions of CD11b+Gr-1+ MDSC and promoted accumulation of these cells and their subtypes in lymphoid organ and metastases. ES treatment promoted low G-CSF plasmatic levels which were produced by the tumor microenvironment, reflecting the reduced metastatic accumulation of CD11b+Gr-1+ MDSC in the lungs. However, the therapy was selective for granulocytic cells, thus reducing the production of ROS. Conclusion: These findings confirm the expansion of MDSC during metastatic progression of RCC and indicate the important role of ES in reducing MDSC and possible use of ES therapy in combined anticancer treatment.

Expression of FLT3 and VEGFR1 on myeloid derived suppressor cells (MDSC) in renal cell carcinoma (RCC) patients (Pts)

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 5108-5108 ◽  
Author(s):  
S. George ◽  
P. Rayman ◽  
S. Biswas ◽  
T. Smith-Williams ◽  
J. S. Ko ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells

scholarly journals Arginase, Prostaglandins, and Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma

2007 ◽  
Vol 13 (2) ◽  
pp. 721s-726s ◽  
Author(s):  
Augusto C. Ochoa ◽  
Arnold H. Zea ◽  
Claudia Hernandez ◽  
Paulo C. Rodriguez
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Suppressor Cells ◽  
Myeloid Derived Suppressor Cells
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