1492 BIOCHEMICAL PROGRESSION FREE SURVIVAL AFTER RADICAL PROSTATECTOMY IN MEN WITH HIGH-RISK CLINICALLY LOCALISED PROSTATE CANCER

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Joseph Ischia ◽  
Larry Goldenberg ◽  
Alan So ◽  
Peter Black ◽  
Martin Gleave
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Progression Free Survival ◽  
Free Survival ◽  
Biochemical Progression

Prognostic Value of Endocan in Prostate Cancer: Clinicopathologic Association between Serum Endocan Levels and Biochemical Recurrence after Radical Prostatectomy

2016 ◽  
Vol 103 (2) ◽  
pp. 204-208 ◽  
Author(s):  
Burak Arslan ◽  
Özkan Onuk ◽  
İsmet Hazar ◽  
Muammer Aydın ◽  
Nusret Can Çilesiz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Biochemical Recurrence ◽  
Specific Antigen ◽  
Elevated Serum ◽  
Progression Free Survival ◽  
Control Group ◽  
Free Survival ◽  
Biochemical Progression

Purpose To assess the diagnostic capability of serum endocan level in association with clinicopathologic features and its impact on biochemical progression-free survival in patients with prostate cancer (PCa). Methods A total of 86 patients with localized prostate cancer were treated with open radical prostatectomy (RP). The control group included 80 patients who were referred to the urology outpatient clinic with normal rectal examination and prostate-specific antigen (PSA) levels. The patients’ characteristics, baseline PSA value, and serum endocan levels were recorded. The patients were followed up with the measurement of PSA concentration every 3 months during the first year, thereafter every 6 months until 5 years, then yearly after surgery. The primary endpoint of follow-up was the time of biochemical recurrence. Results The median serum endocan levels were 3.14 ng/mL in the RP group and 2.98 ng/mL in the control group (p = 0.122). A total of 86 patients who underwent RP for PCa were divided into 2 groups based on a cutoff serum endocan level of 1.8 ng/mL. The distribution of Gleason score and biochemical failure rate were significantly higher in patients with serum endocan ≥1.8 ng/mL (p = 0.031 and p = 0.047). The biochemical recurrence-free time for endocan ≥1.8 ng/mL and <1.8 ng/mL were 38 and 56 months, respectively (p = 0.041). Spearman correlation analysis showed a linear relationship between endocan expression and Gleason score (p = 0.025, p = 0.511). Multivariate analysis revealed that elevated serum endocan level (≥1.8 ng/mL) was a significant predictor of biochemical progression-free survival (hazard ratio 2.44; 95% confidence interval 1.78-3.23; p = 0.001). Conclusions The current study indicates that endocan has a close relationship with tumor recurrence in PCa.

Post-operative conformal radiotherapy on prostate cancer after radical prostatectomy. Results and dose constraint on bladder volume

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14647-14647
Author(s):  
R. A. Nakamura ◽  
C. R. Monti ◽  
R. Ferrigno ◽  
F. A. Trevisan ◽  
L. N. Castilho ◽  
...  
Keyword(s):  
High Risk ◽  
Radical Prostatectomy ◽  
Radiation Dose ◽  
Progression Free Survival ◽  
Conformal Radiotherapy ◽  
Biochemical Failure ◽  
Bladder Volume ◽  
Biochemical Control ◽  
Free Survival ◽  
Biochemical Progression

14647 Background: To report on the results of post-operative conformal radiotherapy (3DCRT) on patients submitted to radical prostatectomy with high risk of biochemical failure or with biochemical failure. Methods: From July 1998 to December 2001, 40 patients with high risk of biochemical failure (T3 stage or positive margins) or with biochemical failure (PSA ≥ 0.2 ng/ml) after radical prostatectomy were submitted to 3DCRT on a single institution and were analyzed retrospectively. The median age was 65 years (52–74). The median pre-3DCRT PSA was 1.3 ng/ml (0–8.98). Twenty eight patients were submitted to pelvic 3DCRT. The median radiation dose on prostate region was 77 Gy (68.4–81). Biochemical failure was considered after 3 consecutive PSA increasing or the beginning of androgen suppression therapy for any reason after 3DCRT. Results: The median follow-up was 56.1 months (19.7–84.6). The 5-year actuarial biochemical progression-free survival was 84.5%. Six (15%) patients had biochemical failure and 4 (10%) distant metastases. The 5-year actuarial biochemical progression-free survival was 94.9% with pre-3DCRT PSA ≤1.5 ng/ml and 69.9% when >1.5 ng/ml (p = 0.0215). Two patients had rectal bleeding grade 2. Nine patients had urinary toxicity grade 2–3. The 5-year actuarial free from urinary toxicity grade 2–3 was 72.9%. Age >65 years and radiation dose >65 Gy on 30% of bladder volume resulted on more late urinary toxicity grade 2–3 (p = 0.0410 and p = 0.0177, respectively). Conclusions: 3DCRT was effective for biochemical control on patients with high risk of biochemical failure or with biochemical failure after radical prostatectomy. Patients with pre-3DCRT PSA ≤1.5 ng/ml have more biochemical control. It was suggested to restrict radiation dose ≤65 Gy on 30% of bladder volume to minimize late grade 2–3 urinary toxicity. More cautious on patients >65 years submitted to post-operative irradiation are required. No significant financial relationships to disclose.

scholarly journals Adjuvant radiotherapy versus observation alone, after radical prostatectomy in high risk prostate cancer

2015 ◽  
Vol 61 (4) ◽  
pp. 324-328 ◽  
Author(s):  
Andrea Petruzziello ◽  
Massakazu Kato ◽  
Lais Cristine Nienkotter ◽  
Luis Felipe Matiusso de Souza ◽  
Luiz Antônio Negrão Dias ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Adjuvant Radiotherapy ◽  
Progression Free Survival ◽  
Radiotherapy Group ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer ◽  
Biochemical Progression

SummaryObjectives:the authors compared biochemical and clinical outcomes of patients with resected high-risk prostate cancer, managed with adjuvant radiotherapy or observation alone.Methods:patients treated with radical prostatectomy (RP) between January 1995 and December 2005 at the authors’ department were evaluated. Patients with pT3, with or without positive surgical margins (PSM), were included for analysis. Demographic, clinical, pathologic and follow-up data were recorded. Comparison was made between adjuvant radiotherapy group (AR) and observation alone group (OA). Primary end-point was biochemical progression-free survival.Results:out of 739 patients treated with RP, 49 presented with pT3 with or without PSM. 39 received adjuvant radiotherapy and 10 were observed. Median follow- up was 6.2 years for AR and 7.3 years for OA. Biochemical progression occurred in 12.8%, in AR, and 70%, in OA (p=0.0008). Five-year biochemical progression-free survival was 87.1% in AR and 30% in OA (HR 0.12, 95% CI 0.03- 0.48 – p<0.0001). Rescue androgen deprivation therapy was needed in 2.6%, in AR, and 30%, in OA (p=0.023).Conclusions:adjuvant radiotherapy after radical prostatectomy in high-risk prostate cancer provided better biochemical outcomes. Whether this translates into better clinical progression, it is still unknown.

Phase III Postoperative Adjuvant Radiotherapy After Radical Prostatectomy Compared With Radical Prostatectomy Alone in pT3 Prostate Cancer With Postoperative Undetectable Prostate-Specific Antigen: ARO 96-02/AUO AP 09/95

2009 ◽  
Vol 27 (18) ◽  
pp. 2924-2930 ◽  
Author(s):  
Thomas Wiegel ◽  
Dirk Bottke ◽  
Ursula Steiner ◽  
Alessandra Siegmann ◽  
Reinhard Golz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Prostate Specific Antigen ◽  
Adjuvant Radiotherapy ◽  
Specific Antigen ◽  
Progression Free Survival ◽  
Phase Iii ◽  
Free Survival ◽  
Wait And See ◽  
Biochemical Progression

Purpose Local failure after radical prostatectomy (RP) is common in patients with cancer extending beyond the capsule. Two randomized trials demonstrated an advantage for adjuvant radiotherapy (RT) compared with a wait-and-see policy. We conducted a randomized, controlled clinical trial to compare RP followed by immediate RT with RP alone for patients with pT3 prostate cancer and an undetectable prostate-specific antigen (PSA) level after RP. Methods After RP, 192 men were randomly assigned to a wait-and-see policy, and 193 men were assigned to immediate postoperative RT. Eligible patients had pT3 pN0 tumors. Patients who did not achieve an undetectable PSA after RP were excluded from treatment according to random assignment (n = 78; 20%). Of the remaining 307 patients, 34 patients on the RT arm did not receive RT and five patients on the wait-and-see arm received RT. Therefore, 114 patients underwent RT and 154 patients were treated with a wait-and-see policy. The primary end point was biochemical progression-free survival. Results Biochemical progression-free survival after 5 years in patients with undetectable PSA after RP was significantly improved in the RT group (72%; 95% CI, 65% to 81%; v 54%, 95% CI, 45% to 63%; hazard ratio = 0.53; 95% CI, 0.37 to 0.79; P = .0015). On univariate analysis, Gleason score more than 6 and less than 7, PSA before RP, tumor stage, and positive surgical margins were predictors of outcome. The rate of grade 3 to 4 late adverse effects was 0.3%. Conclusion Adjuvant RT for pT3 prostate cancer with postoperatively undetectable PSA significantly reduces the risk of biochemical progression. Further follow-up is needed to assess the effect on metastases-free and overall survival.

Sign in / Sign up

Export Citation Format

Share Document