Long Noncoding RNA MALAT-1 is a New Potential Therapeutic Target for Castration Resistant Prostate Cancer

2013 ◽  
Vol 190 (6) ◽  
pp. 2278-2287 ◽  
Author(s):  
Shancheng Ren ◽  
Yawei Liu ◽  
Weidong Xu ◽  
Yi Sun ◽  
Ji Lu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Castration Resistant Prostate Cancer ◽  
Potential Therapeutic Target ◽  
Castration Resistant

XIST: A Meaningful Long Noncoding RNA in NSCLC Process

2020 ◽  
Vol 26 ◽  
Author(s):  
Yujie Shen ◽  
Yexiang Lin ◽  
Kai Liu ◽  
Jinlan Chen ◽  
Juanjuan Zhong ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Critical Role ◽  
Biological Functions ◽  
Potential Therapeutic Target ◽  
Considerable Evidence ◽  
Lncrna Xist ◽  
Nsclc Patients ◽  
The Relationship

Background: A number of studies have proposed that lncRNA XIST plays a role in the development and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC. Methods: In this review, relevant researches involving in the relationship between XIST and NSCLC are collected through systematic retrieval of PubMed Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has shown that XIST exerts a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC cells. XIST mainly functions as a ceRNA in NSCLC process, while XIST also functions at transcriptional levels. Conclusion: LncRNA XIST has potential to become a novel biomolecular marker of NSCLC and a therapeutic target for NSCLC.

The emerging role of noncoding RNA in prostate cancer progression and its implication on diagnosis and treatment

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Prostate Cancer ◽  
Tumor Growth ◽  
Cancer Progression ◽  
Noncoding Rna ◽  
Castration Resistant Prostate Cancer ◽  
Systematic Analysis ◽  
Castration Resistant ◽  
Insight Into ◽  
Generation Sequencing

Recent transcriptome studies using next-generation sequencing have detected aberrant changes in the expression of noncodingRNAs (ncRNAs) associated with cancer. For prostate cancer, the expression levels of ncRNAs including microRNAsand long noncoding RNAs are strongly associated with diagnosis, carcinogenesis and tumor growth. Moreover, androgenand its cognate receptor, androgen receptor (AR), regulate various signaling pathways for prostate tumor growth. In addition,progression to lethal castration-resistant prostate cancer (CRPC) is also owing to AR function. Systematic analysis ofAR-binding sites and their regulated transcripts revealed that many ncRNAs are widely regulated at the transcriptionallevel. Thus, recent studies provide new insight into the complicated molecular mechanism of prostate cancer progression.This review focused on the role of various ncRNAs in prostate cancer and the association between their expression andCRPC.

Abstract 5219: Kaiso as a novel therapeutic target in castration-resistant prostate cancer (CRPC)

2019 ◽  
Author(s):  
Hui-Xian Lin ◽  
Honghe Wang ◽  
Jason White ◽  
Balasubramanyam Karanam ◽  
Anghesom Ghebremedhin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Target ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Novel Therapeutic
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