scholarly journals A novel long noncoding RNA regulating cholesterol and bile acid homeostasis: A new kid on the block and a potential therapeutic target?

Hepatology ◽  
2016 ◽  
Vol 64 (1) ◽  
pp. 16-18 ◽  
Author(s):  
Meenakshisundaram Ananthanarayanan
Keyword(s):  
Bile Acid ◽  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Potential Therapeutic Target

XIST: A Meaningful Long Noncoding RNA in NSCLC Process

2020 ◽  
Vol 26 ◽  
Author(s):  
Yujie Shen ◽  
Yexiang Lin ◽  
Kai Liu ◽  
Jinlan Chen ◽  
Juanjuan Zhong ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Critical Role ◽  
Biological Functions ◽  
Potential Therapeutic Target ◽  
Considerable Evidence ◽  
Lncrna Xist ◽  
Nsclc Patients ◽  
The Relationship

Background: A number of studies have proposed that lncRNA XIST plays a role in the development and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC. Methods: In this review, relevant researches involving in the relationship between XIST and NSCLC are collected through systematic retrieval of PubMed Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has shown that XIST exerts a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC cells. XIST mainly functions as a ceRNA in NSCLC process, while XIST also functions at transcriptional levels. Conclusion: LncRNA XIST has potential to become a novel biomolecular marker of NSCLC and a therapeutic target for NSCLC.

Long Noncoding RNA MALAT-1 is a New Potential Therapeutic Target for Castration Resistant Prostate Cancer

2013 ◽  
Vol 190 (6) ◽  
pp. 2278-2287 ◽  
Author(s):  
Shancheng Ren ◽  
Yawei Liu ◽  
Weidong Xu ◽  
Yi Sun ◽  
Ji Lu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Castration Resistant Prostate Cancer ◽  
Potential Therapeutic Target ◽  
Castration Resistant

scholarly journals Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma

2015 ◽  
Vol 34 (6) ◽  
pp. 932-941 ◽  
Author(s):  
Xianyi Cai ◽  
Yunlu Liu ◽  
Wen Yang ◽  
Yun Xia ◽  
Cao Yang ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Potential Therapeutic Target

Long noncoding RNA: a new contributor and potential therapeutic target in fibrosis

Epigenomics ◽  
2017 ◽  
Vol 9 (9) ◽  
pp. 1233-1241 ◽  
Author(s):  
Xiaoying Jiang ◽  
Fujun Zhang
Keyword(s):  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Potential Therapeutic Target

scholarly journals Proliferation‐associated long noncoding RNA, TMPO‐AS1 , is a potential therapeutic target for triple‐negative breast cancer

2020 ◽  
Vol 111 (7) ◽  
pp. 2440-2450 ◽  
Author(s):  
Yuichi Mitobe ◽  
Kazuhiro Ikeda ◽  
Wataru Sato ◽  
Yukinobu Kodama ◽  
Mitsuru Naito ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Triple Negative ◽  
Potential Therapeutic Target

scholarly journals Linking long noncoding RNA to control bile acid signaling and cholestatic liver fibrosis

Hepatology ◽  
2017 ◽  
Vol 66 (4) ◽  
pp. 1032-1035 ◽  
Author(s):  
John Y.L. Chiang
Keyword(s):  
Bile Acid ◽  
Liver Fibrosis ◽  
Long Noncoding Rna ◽  
Noncoding Rna

scholarly journals Long Noncoding RNA H19: A Novel Therapeutic Target Emerging in Oncology Via Regulating Oncogenic Signaling Pathways

2021 ◽  
Vol 9 ◽  
Author(s):  
Baokang Wu ◽  
Yizhou Zhang ◽  
Yang Yu ◽  
Chongli Zhong ◽  
Qi Lang ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Regulatory Function ◽  
Migration And Invasion ◽  
Oncogenic Signaling ◽  
Regulatory Relationship ◽  
Oncogenic Signaling Pathways ◽  
Novel Therapeutic

Long noncoding RNA H19 (H19) is an imprinting gene with only maternal expression that is involved in regulating different processes in various types of cells. Previous studies have shown that abnormal H19 expression is involved in many pathological processes, such as cancer, mainly through sponging miRNAs, interacting with proteins, or regulating epigenetic modifications. Accumulating evidence has shown that several oncogenic signaling pathways lead to carcinogenesis. Recently, the regulatory relationship between H19 and oncogenic signaling pathways in various types of cancer has been of great interest to many researchers. In this review, we discussed the key roles of H19 in cancer development and progression via its regulatory function in several oncogenic signaling pathways, such as PI3K/Akt, canonical Wnt/β-catenin, canonical NF-κB, MAPK, JAK/STAT and apoptosis. These oncogenic signaling pathways regulated by H19 are involved in cell proliferation, proliferation, migration and invasion, angiogenesis, and apoptosis of various cancer cells. This review suggests that H19 may be a novel therapeutic target for cancers treatment by regulating oncogenic signaling pathways.

scholarly journals Analysis of Long Noncoding RNA and mRNA Profiling in Peripheral Blood Mononuclear Cells of Human Immunized With Rabies Virus Vaccine by RNA Sequencing

2020 ◽  
Author(s):  
Pingsen Zhao ◽  
Kaijian Hou ◽  
Peibin Zeng ◽  
Songtao Yang ◽  
Xianzhu Xia
Keyword(s):  
Rna Sequencing ◽  
Rabies Virus ◽  
Virus Vaccine ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Mononuclear Cells ◽  
Epigenetic Landscape ◽  
Potential Therapeutic Target ◽  
Peripheral Blood Mononuclear ◽  
First Time

Abstract Background Rabies is still a lethal disease caused by rabies virus (RABV), and it remains a global health threaten. The epigenetic landscape of host in response to immunization with rabies virus vaccine is not yet elucidated. Evidences reveal that long noncoding RNA (lncRNA) play an important role for control of viral infection, but the expression profile of lncRNA in human immunized with rabies virus vaccine remains unclear. Methods lncRNA and mRNA profiles were investigated in four volunteers vaccinated with RABV vaccine by RNA sequencing. Results 33 lnRNAs and 427 mRNAs were differentially expressed in RABV vaccine immunized volunteers. The gene oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to analysis the functional annotation, and the result suggested the lncRNAs involved in signaling pathways related to host immune induced by the RABV vaccine. Conclusions To the best of our knowledge, it is the first time to report the transcriptomic landscape of lncRNAs in human immunized with RABV vaccine. Our study mimics the host response of human to RABV infection and suggests that lncRNAs might be of a potential therapeutic target in anti-rabies virus strategies.

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