The Prospects for Socialist Politics in South Africa

Our article endeavours to critically examine the prospects for socialist parties and socialist policy reform in South Africa. Firstly, we seek to provide an appraisal of modern socialist politics and policies globally. Secondly, we attempt to diagnose why South Africa has been as yet unable to fashion a suitable socialist workers’ party during the democratic epoch. In this, the article discusses the prospects of socialist parties and policy reform in South Africa after examining the failure of the Socialist Revolutionary Workers’ Party (SRWP) to make an impact at the 2019 polls. Using a combination of comparative methodology and critical inquiry, our study presents not only that socialist politics and policies are valuable to democratic systems, but also that socialist politics should have a more viable vehicle in South Africa. The prospects for deepened ideological development, particularly the formation of a successful socialist or workers’ party, remains quite weak in South Africa but there is considerable evidence to suggest that civil society both requires and desires a more vibrant relationship with modern socialism.

Raman microspectroscopy imaging analysis of extracellular vesicles (EVs) biogenesis by filamentous fungus Penicilium chrysogenum

Mechanism of production of extracellular vesicles (EVs) and their molecular contents are of great interest owing to their diverse roles in biological systems and are far from being completely understood. Even though, cellular cargo release mediated by EVs have been demonstrated in several cases, their role in secondary metabolite production and release remains elusive. In this study we investigate this aspect in detail using Raman micro-spectroscopic imaging. We provide considerable evidence to suggest that the release of antibiotic penicillin by filamentous fungus Penicillium chrysogenuminvolves EVs. Morphological modifications of the fungal body during biogenesis, changes in cell composition at the locus of biogenesis, and major molecular contents of the released EVs are also revealed in this study.

Interplay Between Gut Microbiota and Amino Acid Metabolism in Heart Failure

Heart failure (HF) is a complex clinical syndrome of which the incidence is on the rise worldwide. Cardiometabolic disorders are associated with the deterioration of cardiac function and progression of HF. Recently, there has been renewed interest in gut microbiota (GM) and its metabolites in the cardiovascular disease. HF-caused hypoperfusion could increase intestinal permeability, and a “leaky” bowel leads to bacterial translocation and make its metabolites more easily enter the circulation. Considerable evidence shows that the composition of microbiota and amino acids (AAs) has been altered in HF patients, and AAs could serve as a diagnostic and prognostic biomarker in HF. The findings indicate that the gut–amino acid–HF axis may play a key role in the progression of HF. In this paper, we focus on the interrelationship between the AA metabolism and GM alterations during the development of heart failure. We also discuss the potential prognostic and therapeutic value of the gut–amino acid–HF axis in the cortex of HF.

County Over Party: How Governors Prioritized Geography Not Particularism in the Distribution of Opportunity Zones

Allocating resources is a central function of government, and the distributive politics literature provides considerable evidence of leaders around the world directing resources to co-partisan voters and officials. In the United States, studies of ‘presidential particularism’ have recently demonstrated strategic targeting by the federal executive branch. This letter extends the inquiry to states using an unusually rich case in which all governors simultaneously faced decisions about allocating a constrained resource – tax advantaged status for economic development – from an exogenously generated list of geographic possibilities. This study tests whether governors rewarded their supporters' and allies' areas alongside two alternatives: (1) spreading the wealth by geographic subunits and (2) policy need. It finds no evidence of gubernatorial particularism. Instead, Republicans and Democratic governors prioritized allocating opportunity zones geographically and made efforts to designate at least one in each county. They were also responsive to policy need.

Criminal Histories and Rates of Recidivism Among Two Subtypes of Psychopathic Individuals

Although it is well established that individuals with psychopathic traits are a high-risk group for criminal recidivism, there is considerable evidence that psychopathy is a heterogeneous personality disorder comprised of two subtypes who differ on levels of negative affect (NA). However, few studies have examined differences in criminal histories, and fewer still have investigated differences in recidivism among subtypes of psychopathy. The current study compared criminal histories and recidivism rates between psychopathy subtypes differing in NA (high-NA vs. low-NA) within a sample of adult males incarcerated in state prisons. The high-NA and low-NA psychopathy subtypes did not differ on histories of total, nonviolent, or violent crime, and did not differ on rates of total, nonviolent, or violent recidivism. This finding highlights equally high levels of criminal risk associated with both subtypes of psychopathic individuals. Intervention strategies should be prioritized for both subgroups to effectively reduce the criminal costs associated with psychopathy.

The Use of CytoSorb Therapy in Critically Ill COVID-19 Patients: Review of the Rationale and Current Clinical Experiences

The COVID-19 pandemic has led to the biggest global health crisis of our lifetime. There is accumulating evidence that a substantial number of critically ill COVID-19 patients exhibit a dysregulated host response manifesting as cytokine storm or cytokine release syndrome, which in turn contributes to the high observed rates of mortality. Just as in other hyperinflammatory conditions, extracorporeal cytokine removal may have potential beneficial effects in this subgroup of COVID-19 patients. The CytoSorb blood purification device is the most extensively investigated cytokine removal platform with considerable evidence suggesting that early intervention can provide rapid hemodynamic stabilization and improvement in vital organ functions. The purpose of this review is to provide an overview of the pathophysiological background of hyperinflammation in COVID-19 and to summarize the currently available evidence on the effects of hemoadsorption in these patients.

Are Irrelevant Items Actively Deleted from Visual Working Memory?: No Evidence from Repulsion Effects in Dual-Retrocue Tasks

In addition to processes associated with maintaining, manipulating, and updating to-be-remembered information for ongoing cognition, some theories suggest that working memory (WM) also involves the active deletion of irrelevant information, including items that were retained in WM, but are no longer relevant for ongoing cognition. Considerable evidence provides support for an active deletion mechanism, particularly for categorical representations (Rose et al., 2016; Fulvio & Postle, 2020; but see Bae & Luck, 2017 for contradictory evidence with line orientations). On each trial of the current task, healthy young adults maintained two line orientations in visual WM, switched attention to maintaining and recalling the orientation cued first, and then switched to recall the item cued second, at which point the uncued orientation was no-longer-relevant on the trial. The results showed that the no-longer-relevant items exerted the strongest “repulsive” bias on participants’ recall of to-be-remembered items, directly contradicting the active deletion hypothesis. We suggest that visual WM binds features like line orientations into ensemble representations, and an irrelevant feature of a bound object cannot be actively deleted--it biases recall of the target feature via repulsion. Models of WM will need to be updated to explain this dynamic phenomenon.

Could there be no wave-particle duality, but only waves?

Here, the concept of a wave-particle duality is questioned. First, the experimental proofs existing, respectively, for particles and waves are examined. In the case of particles, no experimental evidence can be found which establishes them; it seems that particles have always been taken for granted. In the case of waves, considerable evidence has accumulated with results on diffraction, interference, and self-interference of larger and larger objects. Then an important remark is made concerning the fact that unlike particles, waves are not observation-dependent: waves existed before observation otherwise the patterns of diffraction or interference would not have been appearing; the wave nature does not depend on the making of a measurement, there is no measurement problem for waves. Consequently, since waves are not observation-dependent, if the objects are demonstrated to be waves, they are only waves. This fact, along with some other evidence, disagrees with the current interpretation of the Wheeler-type delayed-choice experiments, where the absence of interference is interpreted as a particle behavior. Finally, recent works regarding the de Broglie‐Bohm theory are presented, which lead to suggest a new wave-only version of this theory. It is concluded that a wave-only view might be worth considering instead of the wave-particle duality view which has prevailed so far.

Pharmacological Modulation of Toll-Like Receptors in Brain Disorders

The knowledge regarding pathological and treatment resistance mechanisms involved in the pathology of complex brain disorders is far from understood. The neuroinflammation hypothesis of psychiatric, neurological, and neurodegenerative diseases is well-acknowledged. However, this hypothesis is far from understood. Toll-like receptors (TLRs) family is an innate immunity molecule implicated in neuroinflammation in complex brain disorders. This chapter reviews considerable evidence indicating that activation of endotoxins such as lipopolysaccharide is a common factor. Additionally, we report clinical and preclinical studies highlighting the link between lipopolysaccharide, TLRs, and different types of brain disorders. Also, we review the current pharmacological modulations of TLRs. Hoping we would help in filling our knowledge gaps and highlight potential links to tackle new angles in managing complex brain disorders. This chapter’s primary goal is to encourage scientists and researchers to conduct future studies characterizing the nature of endotoxin activation of TLRs in complex brain disorders, filling our knowledge gaps, and finding new treatment strategies.

Understanding Frailty Screening: a Domain Mapping Exercise

Background Many definitions and operationalisations of frailty exclude psychosocial factors, such as social isolation and mental health, despite considerable evidence of the links between frailty and these factors. This study aimed to investigate the health domains covered by frailty screening tools. Methods A systematic search of the literature was conducted in ac­cordance with PRISMA guidelines. MEDLINE, CINAHL, EMBASE, and PsycInfo were searched from inception to December 31, 2018. Data related to the domains of each screening tool were extracted and mapped onto a framework based on the biopsychosocial model of Lehmans et al. (2009) and Wade & Halligans (2017). Results Sixty-seven frailty screening tools were captured in 79 arti­cles. All screening tools assessed biological factors, 73% assessed psychological factors, 52% assessed social factors, and 78% assessed contextual factors. Under half (43%) of the tools evaluated all four domains, 33% evaluated three of four domains, 12% reported two of four domains, and 13% reported one domain (biological). Conclusion This review found considerable variation in the assessment domains covered by frailty screening tools. Frailty is a broad construct, and frailty screening tools need to cover a wide var­iety of domains to enhance screening and outcomes assessment.