MP03-08 IMPACT OF DYNAMIC CONTRAST-ENHANCED SEQUENCES IN PROSTATE CANCER DETECTION: BIPARAMETRIC VERSUS MULTIPARAMETRIC MRI INTERPRETED BY 5 RADIOLOGY RESIDENTS.

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Paolo Gontero ◽  
Giorgio Calleris ◽  
Giancarlo Marra ◽  
Marco Oderda ◽  
Jacopo Giglio ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Detection ◽  
Multiparametric Mri ◽  
Prostate Cancer Detection ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Radiology Residents

scholarly journals Prostate Cancer Detection with Multiparametric MRI: A Comparison of 1 M-Concentration Gadobutrol with 0.5 M-Concentration Gadolinium-Based Contrast Agents

2017 ◽  
Vol 11 (4) ◽  
pp. 201-205 ◽  
Author(s):  
Takeshi Hara ◽  
Takeshi Ogata ◽  
Hiroko Wada ◽  
Takayuki Yabuki ◽  
Susumu Kanazawa
Keyword(s):  
Prostate Cancer ◽  
Contrast Agents ◽  
Cancer Detection ◽  
Gadopentetate Dimeglumine ◽  
Multiparametric Mri ◽  
Predictive Values ◽  
Prostate Cancer Detection ◽  
Contrast Enhanced ◽  
Gadoterate Meglumine ◽  
Magnetic Resonance Imaging Mri

Introduction: Gadobutrol (Gd-DO3A-butrol) (Gadovist®) is a macrocyclic gadolinium-based contrast agent for magnetic resonance imaging (MRI) formulated at 1.0 mmol Gd/ml. Gadobutrol's higher concentration compared to other contrast agents (0.5 mmol Gd/ml) is associated with higher T1 relaxivity. We examined whether gadobutrol increases the accuracy of prostate cancer detection using dynamic contrast-enhanced MRI. Materials and Methods: Multiparametric MRI was performed in 379 patients: 94 patients received 1 M gadobutrol while 285 randomly received equivalent doses of 0.5 M gadoterate meglumine or gadopentetate dimeglumine. MRI images were retrospectively and blindly assessed for the presence of cancer by comparing them with prostate biopsy findings. Results: The specificity and accuracy were significantly higher with 1 M gadobutrol than 0.5 M of the other contrast agents. There were no significant differences in the sensitivity, or positive and negative predictive values. Conclusion: Multiparametric MRI using 1 M gadobutrol may improve the accuracy of prostate cancer detection.

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