scholarly journals Efficacy and Safety of Insulin Analogues Compared to Human Insulin Preparations for the treatment of Patients With Diabetes Type 1 (Dm1): Systematic Review and Meta-Analysis

2015 ◽  
Vol 18 (3) ◽  
pp. A55
Author(s):  
A.a. Guerra-Junior ◽  
V.E. Araujo ◽  
J.B. Izidoro ◽  
L.M. Diniz ◽  
M.R. Silva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Human Insulin ◽  
Meta Analysis ◽  
Insulin Analogues ◽  
Diabetes Type ◽  
Diabetes Type 1 ◽  
Efficacy And Safety ◽  
Patients With Diabetes

Continuous Glucose Monitoring for Glycemic Control in Children and Adolescents Diagnosed with Diabetes Type 1: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Elena Dorando ◽  
Thomas Haak ◽  
Dawid Pieper
Keyword(s):  
Systematic Review ◽  
Glycemic Control ◽  
Children And Adolescents ◽  
Meta Analysis ◽  
Glucose Monitoring ◽  
Diabetes Type ◽  
Diabetes Type 1 ◽  
Meta Analyses

Abstract Aim The aim of this meta-analysis was to evaluate the impact of continuous glucose monitoring (CGM) systems on short- and long-term glycemic control in children and adolescents diagnosed with diabetes type 1. Methods The review was registered in PROSPERO (CRD42019135152). We partly updated a formerly published systematic review and searched several databases (Ovid MEDLINE, Embase, CENTRAL, and Clinicaltrials.gov) in May 2019. Summary measures were estimated as relative risks (RR) and standardized mean differences (SMD). The primary endpoint of our analysis was frequency of hypoglycemic events. Quality of evidence was evaluated using the GRADE approach. Results Eleven studies with a total number of 818 patients were included in our review. Meta-analyses indicated a potential benefit of CGM systems regarding the relative risk of a severe hypoglycemic event (RR 0.78; 95% CI 0.29 to 2.04) and mean level of HbA1c at end of study (SMD -0.23; 95% CI -0.46 to 0.00). Certainty of evidence for effect estimates of these meta-analyses was low due to risk of selection bias and imprecision of the included studies. Qualitative analyses of the secondary outcomes of user satisfaction and long-term development of blood glucose supported these findings. Conclusion CGM systems may improve glycemic control in children and adolescents diagnosed with diabetes type 1, but the imprecision of effects is still a problem. Only a few studies examined and reported data for pediatric populations in sufficient detail. Further research is needed to clarify advantages and disadvantages of CGM systems in children and adolescents.

scholarly journals Clinical efficacy and safety of insulin aspart compared with regular human insulin in patients with type 1 and type 2 diabetes: a systematic review and meta-analysis

2015 ◽  
Vol 125 (3) ◽  
pp. 141-151
Author(s):  
Piotr Wojciechowski ◽  
Patrycja Niemczyk-Szechowska ◽  
Elżbieta Olewińska ◽  
Patrycja Jaros ◽  
Barbara Mierzejewska ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Human Insulin ◽  
Clinical Efficacy ◽  
Insulin Aspart ◽  
Meta Analysis ◽  
Regular Human Insulin ◽  
Efficacy And Safety

scholarly journals Association of myocardial fibrosis detected by late gadolinium-enhanced MRI with clinical outcomes in patients with diabetes: a systematic review and meta-analysis

BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e055374
Author(s):  
Zhi Yang ◽  
Rong Xu ◽  
Jia-rong Wang ◽  
Hua-yan Xu ◽  
Hang Fu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Risk Stratification ◽  
Myocardial Fibrosis ◽  
Meta Analysis ◽  
Imaging Biomarker ◽  
Cardiac Events ◽  
Prognostic Information ◽  
Increased Risk ◽  
Patients With Diabetes

ObjectiveThis meta-analysis assessed the associations of myocardial fibrosis detected by late gadolinium-enhanced (LGE)-MRI with the risk of major adverse cardiac and cerebrovascular events (MACCEs) and major adverse cardiac events (MACEs) in patients with diabetes.DesignSystematic review and meta-analysis reported in accordance with the guidelines of the Meta-analysis of Observational Studies in Epidemiology statement.Data sourcesWe searched the Medline, Embase and Cochrane by Ovid databases for studies published up to 27 August 2021.Eligibility criteriaProspective or respective cohort studies were included if they reported the HR and 95% CIs for MACCEs/MACEs in patients with either type 1 or 2 diabetes and LGE-MRI-detected myocardial fibrosis compared with patients without LGE-MRI-detected myocardial fibrosis and if the articles were published in the English language.Data extraction and synthesisTwo review authors independently extracted data and assessed the quality of the included studies. Pooled HRs and 95% CIs were analysed using a random effects model. Heterogeneity was assessed using forest plots and I2 statistics.ResultsEight studies with 1121 patients with type 1 or type 2 diabetes were included in this meta-analysis, and the follow-up ranged from 17 to 70 months. The presence of myocardial fibrosis detected by LGE-MRI was associated with an increased risk for MACCEs (HR: 2.58; 95% CI 1.42 to 4.71; p=0.002) and MACEs (HR: 5.28; 95% CI 3.20 to 8.70; p<0.001) in patients with diabetes. Subgroup analysis revealed that ischaemic fibrosis detected by LGE was associated with MACCEs (HR 3.80, 95% CI 2.38 to 6.07; p<0.001) in patients with diabetes.ConclusionsThis study demonstrated that ischaemic myocardial fibrosis detected by LGE-MRI was associated with an increased risk of MACCEs/MACEs in patients with diabetes and may be an imaging biomarker for risk stratification. Whether LGE-MRI provides incremental prognostic information with respect to MACCEs/MACEs over risk stratification by conventional cardiovascular risk factors requires further study.

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