scholarly journals 3:00 PM Abstract No. 390 SBRT versus thermal ablation for treatment of hepatocellular carcinoma: impact on the MELD score in cirrhotic patients

2018 ◽  
Vol 29 (4) ◽  
pp. S167
Author(s):  
D. Johnson ◽  
Q. Wang ◽  
S. Perkins ◽  
J. Ronald ◽  
C. Kim
Keyword(s):  
Hepatocellular Carcinoma ◽  
Thermal Ablation ◽  
Meld Score ◽  
Cirrhotic Patients

Frequency of High MELD Score in Cirrhotic Patients undergoing Liver Resection due to Hepatocellular Carcinoma

2021 ◽  
Vol 15 (9) ◽  
pp. 2841-2843
Author(s):  
Muhammad Omer Farooq ◽  
Niaz Ahmed ◽  
Hassan Nadeem ◽  
Kashif Rafi ◽  
Sadia Jabbar ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Cross Sectional Study ◽  
Meld Score ◽  
Cross Sectional ◽  
Female Ratio ◽  
Score Study ◽  
Insignificant Difference ◽  
Cirrhotic Patients ◽  
Male To Female

Objective: To determine the frequency of high MELD score in cirrhotic patients undergoing liver resection due to hepatocellular carcinoma also compare the frequency of mortality in patients with high or low MELD score. Study Design: Cross sectional study Place and Duration: Department of Gastroenterology, Shaikh Zayed Hospital, Lahore. Duration: 6months i.e. 23 12-2017 to 22-06-2018. Methodology: 75 patients were enrolled. Then blood sample was obtained. Reports assessed and MELD score calculated. Scores were labeled as high or low. Patients underwent liver resection according to BCLC. The mortality was noted. All the collected data was entered and analyzed on SPSS version 22. Results: In this study out of total 75 cases 60 were males and 15 females. The mean age of patients was 39.44±9.76 years, male to female ratio was 4:1. Low MELD class was noted in 45 (60%) cases and high MELD class noted in 30(40%) cases. Mortality occurred in 27(36%) cases. Insignificant difference found between the MELD class with mortality. Conclusion: High MELD score was seen in 40% cirrhotic patients undergoing liver resection due to HCC. Post HCC resection, mortality occurred in 36% patients within three months of surgery. No significant association was found between the mortality and MELD score. Keywords: MELD, Hepatocellular Carcinoma, Mortality, Cirrhosis

scholarly journals Thermal ablation of large unresectable hepatocellular carcinoma in cirrhotic patients

2018 ◽  
Vol 4 (9) ◽  
pp. 53
Author(s):  
Giovan Giuseppe Di Costanzo ◽  
Raffaella Tortora ◽  
Anna Opramolla ◽  
Marco Guarracino
Keyword(s):  
Hepatocellular Carcinoma ◽  
Thermal Ablation ◽  
Unresectable Hepatocellular Carcinoma ◽  
Cirrhotic Patients

scholarly journals WAITING DAAS LIST MORTALITY IMPACT IN HCV CIRRHOTIC PATIENTS

2018 ◽  
Vol 55 (4) ◽  
pp. 343-345 ◽  
Author(s):  
Giovanni Faria SILVA ◽  
Vanessa Gutierrez de ANDRADE ◽  
Alecsandro MOREIRA
Keyword(s):  
Hepatocellular Carcinoma ◽  
Regression Analysis ◽  
Cox Regression ◽  
Antiviral Agents ◽  
Meld Score ◽  
New Drugs ◽  
Cox Regression Analysis ◽  
Kaplan Meier ◽  
Cirrhotic Patients ◽  
Direct Antiviral Agents

ABSTRACT BACKGROUND: The infection for the hepatitis C virus (HCV) is a leading cause of liver-related morbidity and mortality through its evolution to liver cirrhosis, end-stage liver complications and hepatocellular carcinoma. Currently, the new drugs for the HCV infection, based on direct antiviral agents, have changed the outcomes in this setting. OBJECTIVE: To assess death incidence, during the wait for the treatment with the new drugs, and to analyze which independent variable (age, sex, ascite, HDA, albumin, α-fetoprotein, platelets and Meld score) had relation with death. METHODS: Prospective study with cirrhotic patients by HCV. Inclusion: cirrhotic patients by hepatic biopsy (METAVIR), clinic or image, detectable RNA (HCV). Exclusion: Other stages of hepatic fibrosis and hepatocellular carcinoma. Descriptive statistic in continue variables. Fisher Exact and Kaplan Meier and Cox Regression Analysis to assess the association of variables studied with death. P<0.05. RESULTS: A total of 129 patients were included. Of this, 73% were men. Mean age was 57.8±12.1, albumin of 3.5±0.6 mg/dL, platelets of 123.4±59.6 and Meld score of 10.59±3.56. The time of observation was 11.2±3.26 months, and the number of death 9/129 (6,9%). The Kaplan-Meier showed association between death with albumin lower than 2.9 (0.0006), MELD score higher than 15 (0.007) and α-fetoprotein higher than 40 ng/mL (<0.0001). Adjusted Cox Regression Analysis showed that α-fetoprotein higher than 40 ng/ml could be considered an independent risk for death. CONCLUSION: We conclude that, patients with advanced cirrhosis should be prioritized for treatment with direct antiviral agents.

scholarly journals COMPARATIVE STUDY ON LIVER TRANSPLANTATION WITH AND WITHOUT HEPATOCELLULAR CARCINOMA WITH CIRRHOSIS: ANALYSIS OF MELD, WAITING TIME AND SURVIVAL

2016 ◽  
Vol 29 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Alexandre Coutinho Teixeira de FREITAS ◽  
Rafael Shinmi SHIGUIHARA ◽  
Ruan Teles MONTEIRO ◽  
Thiago Linck PAZETO ◽  
Júlio Cezar Uili COELHO
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Waiting Time ◽  
Analytical Study ◽  
Meld Score ◽  
Sex Distribution ◽  
B Virus ◽  
Cirrhotic Patients ◽  
One Year ◽  
Age And Sex

Background: Liver transplantation is the usual treatment for hepatocellular carcinoma. Aim : To analyze the MELD score, waiting time and three month and one year survival for liver transplantation in cirrhotic patients affected by hepatocellular carcinoma or not. Methods: This was a retrospective, observational and analytical study of 93 patients submitted to liver transplantation. Results: There were 28 hepatocellular carcinoma and 65 non-hepatocellular carcinoma patients with no differences related to age and sex distribution. The main causes of cirrhosis on hepatocellular carcinoma were hepatitis C virus (57.1%) and hepatitis B virus (28.5%), more frequent than non-hepatocellular carcinoma patients, which presented 27.7% and 4.6% respectively. The physiological and exception MELD score on hepatocellular carcinoma were 11.9 and 22.3 points. On non-hepatocellular carcinoma, it was 19.4 points, higher than the physiological MELD and lower than the exception MELD on hepatocellular carcinoma. The waiting time for transplantation was 96.2 days for neoplasia, shorter than the waiting time for non-neoplasia patients, which was 165.6 days. Three month and one year survival were 85.7% and 78.6% for neoplasia patients, similar to non-neoplasia, which were 77% and 75.4%. Conclusion : Hepatocellular carcinoma patients presented lower physiological MELD score, higher exception MELD score and shorter waiting time for transplantation when compared to non-hepatocellular carcinoma patients. Three month and one year survival were the same between the groups.

Sign in / Sign up

Export Citation Format

Share Document