scholarly journals Intermittent pneumatic compression of the foot and calf improves the outcome of catheter-directed thrombolysis using low-dose urokinase in patients with acute proximal venous thrombosis of the leg

2005 ◽  
Vol 42 (5) ◽  
pp. 940-944 ◽  
Author(s):  
Tomohiro Ogawa ◽  
Shunichi Hoshino ◽  
Hirofumi Midorikawa ◽  
Kouichi Sato
Keyword(s):  
Venous Thrombosis ◽  
Low Dose ◽  
Intermittent Pneumatic Compression ◽  
Catheter Directed Thrombolysis

scholarly journals Catheter-Directed Thrombolysis With a Continuous Infusion of Low-Dose Alteplase for Subacute Proximal Venous Thrombosis: Efficacy and Safety Compared to Urokinase

2018 ◽  
Vol 24 (8) ◽  
pp. 1333-1339 ◽  
Author(s):  
Maofeng Gong ◽  
Xu He ◽  
Jinhua Song ◽  
Boxiang Zhao ◽  
Wanyin Shi ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Continuous Infusion ◽  
Group Treatment ◽  
Low Dose ◽  
Great Majority ◽  
Recombinant Tissue Plasminogen Activator ◽  
Efficacy And Safety ◽  
Catheter Directed Thrombolysis ◽  
The Uk ◽  
Grade Iii

The purpose of this study was to compare the efficacy and safety associated with catheter-directed thrombolysis (CDT) using either recombinant tissue plasminogen activator (rt-PA) or urokinase (UK) for subacute deep venous thrombosis (DVT). From January 2014 to December 2016, we conducted a retrospective analysis on a total of 49 patients who underwent consistent CDT with either rt-PA (rt-PA-CDT group) or UK (UK-CDT group) treatment. The thrombolytic rate of the rt-PA-CDT group was significantly higher than that of the UK-CDT group (87.5% vs 60%, respectively; χ2 = 4.751; P = .029). The rt-PA-CDT group exhibited an improved grade III thrombolytic rate (9 patients vs 3 patients; χ2 = 5.144; P = .023). The time for the rt-PA-CDT group to achieve a grade III thrombolytic rate was shorter than that of the UK-CDT group (5.01 ± 1.09 days vs 6.43 ± 1.69 days, respectively; t = −2.187; P = .044). No severe complications were seen in either group and mild complications rates were 16.7% and 20.0% (χ2 = .091; P = .763). The clinical efficacy rates at discharge were 91.7% and 76.0%, respectively (χ2 = 2.200; P = .138). In conclusion, CDT with a continuous infusion of low-dose rt-PA resulted in safe and effective thrombolysis in the great majority of patients with proximal DVT in the subacute phase. Furthermore, rt-PA was significantly better than UK in terms of the thrombolytic rate. In our study, rt-PA-CDT improved the thrombolytic rate of grade III thrombus and achieved a grade III thrombolytic rate in a shorter time than UK-CDT.

PREVENTING VENOUS THROMBOSIS (VT) WITH HEPARIN ALONE OR WITH HEPARIN/DIHYDROERGOTAMINE AFTER ELECTIVE HIP REPLACEMENT, A DOUBLE-BLIND, RANDOMISED, VENOGRAM END-POINT COMPARISON

1987 ◽  
Author(s):  
J F Cade ◽  
K W Mills ◽  
A S Gallus ◽  
W Murphy
Keyword(s):  
Venous Thrombosis ◽  
General Surgery ◽  
Hip Replacement ◽  
Low Dose ◽  
Double Blind ◽  
Randomised Study ◽  
Sodium Heparin ◽  
End Point ◽  
Small Doses

Dihydro-ergotaraine (DHE) appears to be synergistic with small doses of hepari when used to prevent VT after general surgery. However, doubt remains whether DHEhas this effect in patients with elective hip replacement (THR). We have therefore compared the results of VT prophylaxis using sub-cutaneous (sc) low-dose heparinalone or sc heparin plus sc DHE in a double-blind, randomised, study of 126 patientshaving elective THR, 98 at centre (1)and 28 at centre (2).All received 5000 iu sodium heparin, hourly for 7 days, starting 2 hours before surgery at centre (1), or immediately after surgery at centre (2). Patients alsoreceived a separate 0.5 ml (0.5 mg) DHEorplacebo injection each time they receivedheparin. Patients had bilateral ascendingvenography on the 7th postoperativeday, and venograms were read before the treatment code was broken.These results do not support the presence of synergism between heparin and DHE in this situation.

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