Skin accumulation of advanced glycation end products is increased in patients with an abdominal aortic aneurysm

Experiments conducted in recent years on animals and research works worldwide show a linkage between calprotectin and occurrence and development of the abdominal aortic aneurysm (AAA). Additionally, a correlation between the level of the receptor for advanced glycation end products (RAGE) and the diameter of the abdominal aorta was found. The purpose of this study was to investigate whether calprotectin and the RAGE plasma level may be a biomarker of human AAA occurrence. We determined two groups of research participants: a group of 32 patients aged 53–88 undergoing primary endovascular aneurysm repair and a control group of 43 volunteers aged 59–82 without the AAA. All the patients from the study group had their blood samples drawn in order to determine the level of calprotectin and RAGE in plasma. The second follow-up examination was carried out after three months. The concentration of calprotectin and RAGE in plasma was determined with the use of the immunoenzymatic method (ELISA). The study showed that patients with the AAA had significantly higher mean calprotectin and RAGE plasma levels (p = 0.0001 and p = 0.0002, respectively) as compared to the control group. After the AAA repair operations, the level of concentration of the calprotectin decreased significantly (p = 0.0002). So far, no studies on the connection between the increase of the calprotectin and RAGE in the patient’s plasma with the AAA have been published. Calprotectin may be a promising biomarker related to the occurrence of AAA. Larger studies are needed to fully elucidate and confirm the role of calprotectin in the development and progression of the aneurysm.

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Genetic deletion of receptor for advanced glycation end products (RAGE) Prevents formation of abdominal aortic aneurysm (AAA) in a murine model

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2011.06.380 ◽

2011 ◽

Vol 213 (3) ◽

pp. S154

Author(s):

Terri L. Ennis ◽

Pamela Kell ◽

Ann Marie Schmidt ◽

Robert W. Thompson ◽

Kathleen G. Raman

Keyword(s):

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Advanced Glycation End Products ◽

Murine Model ◽

Advanced Glycation ◽

Abdominal Aortic ◽

Glycation End Products ◽

End Products ◽

Genetic Deletion

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Anti-Receptor for Advanced Glycation End Products Therapies as Novel Treatment for Abdominal Aortic Aneurysm

Transactions of the Meeting of the American Surgical Association ◽

10.1097/sla.0b013e3181b41a18 ◽

2009 ◽

Vol 127 ◽

pp. 60-67 ◽

Cited By ~ 4

Author(s):

Fan Zhang ◽

K. Craig Kent ◽

Dai Yamanouchi ◽

Yan Zhang ◽

Kaori Kato ◽

...

Keyword(s):

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Advanced Glycation End Products ◽

Advanced Glycation ◽

Novel Treatment ◽

Abdominal Aortic ◽

Glycation End Products ◽

End Products

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Deletion of Myeloid Receptor for Advanced Glycation End Products (RAGE) Prevents Formation of Abdominal Aortic Aneurysm (AAA) in a Murine Model

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2016.08.161 ◽

2016 ◽

Vol 223 (4) ◽

pp. e61

Author(s):

Kathleen G. Raman ◽

Terri L. Ennis ◽

Ann Marie Schmidt ◽

Robert W. Thompson

Keyword(s):

Abdominal Aortic Aneurysm ◽

Aortic Aneurysm ◽

Advanced Glycation End Products ◽

Murine Model ◽

Advanced Glycation ◽

Abdominal Aortic ◽

Glycation End Products ◽

End Products

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The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm

BioMed Research International ◽

10.1155/2017/2791082 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Magdalena Budzyń ◽

Bogna Gryszczyńska ◽

Wacław Majewski ◽

Zbigniew Krasiński ◽

Magdalena Paulina Kasprzak ◽

...

Keyword(s):

Oxidative Stress ◽

Abdominal Aortic Aneurysm ◽

Endothelial Damage ◽

Enzyme Linked Immunosorbent Assay ◽

Advanced Glycation ◽

Abdominal Aortic ◽

Glycation End Products ◽

End Products ◽

And Oxidative Stress ◽

Age And Sex

Background.The aim of the present study was to evaluate the concentration of serum thrombomodulin (sTM) in the AAA patients and to examine its correlation with various factors which may potentially participate in the endothelial injury.Materials and Methods.Forty-one patients with AAA were involved and divided into subgroups based on different criteria. Concentration of sTM was measured using enzyme-linked-immunosorbent assay (ELISA). The results were compared with those obtained in 30 healthy age- and sex-matched volunteers.Results.The higher concentration of sTM was observed in AAA patients compared with those in controls volunteers [2.37 (1.97–2.82) ng/mL versus 3.93 (2.43–9.20) ng/mL,P< 0.001]. An elevated sTM associated significantly with increased triglycerides (TAG) [P= 0.022], cholesterol [P= 0.029], hsCRP [P= 0.031], and advanced glycation end products (AGEs) [P= 0.033].Conclusions.The elevation of serum sTM level suggests that endothelial damage occurs in AAA pathogenesis. The correlations observed indicate that lipids abnormalities, inflammation, and oxidative stress may be involved in this destructive process.

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Association between small fiber neuropathy and higher skin accumulation of advanced glycation end products in patients with type 1 diabetes

Polish Archives of Internal Medicine ◽

10.20452/pamw.3649 ◽

2016 ◽

Vol 126 (11) ◽

pp. 847-853 ◽

Cited By ~ 3

Author(s):

Aleksandra Araszkiewicz ◽

Agnieszka Gandecka ◽

Michał Nowicki ◽

Aleksandra Uruska ◽

Agnieszka Malińska ◽

...

Keyword(s):

Type 1 Diabetes ◽

Advanced Glycation End Products ◽

Small Fiber Neuropathy ◽

Advanced Glycation ◽

Small Fiber ◽

Skin Accumulation ◽

Glycation End Products ◽

End Products

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Association of Polymorphisms of the Receptor for Advanced Glycation End Products Gene and Susceptibility to Sporadic Abdominal Aortic Aneurysm

BioMed Research International ◽

10.1155/2015/394126 ◽

2015 ◽

Vol 2015 ◽

pp. 1-10 ◽

Cited By ~ 4

Author(s):

Ye Yao ◽

Junli Zhuang ◽

You Li ◽

Bao Jing ◽

Hali Li ◽

...

Keyword(s):

Advanced Glycation End Products ◽

Gene Polymorphisms ◽

Smoking Status ◽

Aortic Aneurysms ◽

Advanced Glycation ◽

Soluble Rage ◽

Abdominal Aortic ◽

Significant Difference ◽

Glycation End Products ◽

End Products

Accumulating evidence has suggested that receptor for advanced glycation end products (RAGE) is involved in the development and progression of human abdominal aortic aneurysms (AAAs). However, the association betweenRAGEgene polymorphisms and AAA has not yet been determined. The present study was aimed at analyzing the potential association between theRAGEgene polymorphisms and AAAs. A cohort of 381 patients and 436 age-matched healthy controls were genotyped to detect the threeRAGEpolymorphisms (−374 T/A, −429 T/C, and G82S) using SNaPshot. Our study demonstrated a significant difference in the genotype and allele frequencies of theRAGEG82S polymorphism between the AAA patients and the controls. Further stratification by gender and smoking status revealed that the presence of theRAGE82S allele confers a higher risk for developing AAA in men and smokers. Moreover, AAA patients with the variant 82S allele ofRAGEpresented with reduced serum soluble RAGE (sRAGE) production, and this decrease was more significant in men and smokers with AAA. Our study provides preliminary evidence that the 82S allele ofRAGEis a risk factor for AAA. This new piece of knowledge regarding RAGE may be clinically important for the prevention and therapy of AAAs.

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