Regarding “Prediction of 6-minute walk performance in patients with peripheral artery disease”

2018 ◽  
Vol 67 (5) ◽  
pp. 1634
Author(s):  
Shiva Mansouri Hanis ◽  
Kamyar Mansori
Keyword(s):  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Minute Walk

scholarly journals Minimal clinically important differences in treadmill, 6-minute walk, and patient-based outcomes following supervised and home-based exercise in peripheral artery disease

2018 ◽  
Vol 23 (4) ◽  
pp. 349-357 ◽  
Author(s):  
Andrew W Gardner ◽  
Polly S Montgomery ◽  
Ming Wang
Keyword(s):  
Peripheral Artery Disease ◽  
Exercise Program ◽  
Exercise Group ◽  
Treadmill Test ◽  
Peripheral Artery ◽  
Exercise Programs ◽  
Supervised Exercise ◽  
Home Based ◽  
Artery Disease ◽  
Minute Walk

We estimated minimal clinically important differences (MCIDs) for small, moderate, and large changes in measures obtained from a standardized treadmill test, a 6-minute walk test, and patient-based outcomes following supervised and home-based exercise programs in symptomatic patients with peripheral artery disease (PAD). Patients were randomized to either 12 weeks of a supervised exercise program ( n=60), a home-based exercise program ( n=60), or an attention-control group ( n=60). Using the distribution-based method to determine MCIDs, the MCIDs for small, moderate, and large changes in peak walking time (PWT) in the supervised exercise group were 38, 95, and 152 seconds, respectively, and the changes in claudication onset time (COT) were 35, 87, and 138 seconds. Similar MCID scores were noted for the home-based exercise group. An anchor-based method to determine MCIDs yielded similar patterns of small, moderate, and large change scores in PWT and COT, but values were 1–2 minutes longer than the distribution approach. In conclusion, 3 months of supervised and home-based exercise programs for symptomatic patients with PAD results in distribution-based MCID small, moderate, and large changes ranging from 0.5 and 2.5 minutes for PWT and COT. An anchor-based approach yields higher MCID values, ranging from a minimum of 73 seconds for COT to a maximum of 4 minutes for PWT. The clinical implication is that a goal for eliciting MCIDs in symptomatic PAD patients through a walking exercise intervention is to increase PWT and COT by up to 4 minutes, which corresponds to two work stages during the standardized progressive treadmill test.

scholarly journals Six-Minute Walk Is a Better Outcome Measure Than Treadmill Walking Tests in Therapeutic Trials of Patients With Peripheral Artery Disease

Circulation ◽  
2014 ◽  
Vol 130 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Mary M. McDermott ◽  
Jack M. Guralnik ◽  
Michael H. Criqui ◽  
Kiang Liu ◽  
Melina R. Kibbe ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Outcome Measure ◽  
Treadmill Walking ◽  
Peripheral Artery ◽  
Therapeutic Trials ◽  
Walking Tests ◽  
Artery Disease ◽  
Minute Walk

scholarly journals Prediction of 6-minute walk performance in patients with peripheral artery disease

2017 ◽  
Vol 66 (4) ◽  
pp. 1202-1209 ◽  
Author(s):  
Xi Chen ◽  
Julie A. Stoner ◽  
Polly S. Montgomery ◽  
Ana I. Casanegra ◽  
Federico Silva-Palacios ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Minute Walk

scholarly journals Comparing 6-minute walk versus treadmill walking distance as outcomes in randomized trials of peripheral artery disease

2020 ◽  
Vol 71 (3) ◽  
pp. 988-1001 ◽  
Author(s):  
Mary M. McDermott ◽  
Jack M. Guralnik ◽  
Lu Tian ◽  
Lihui Zhao ◽  
Tamar S. Polonsky ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Randomized Trials ◽  
Treadmill Walking ◽  
Walking Distance ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Minute Walk

Calf Muscle Oxygen Saturation during 6-Minute Walk Test and Its Relationship with Walking Impairment in Symptomatic Peripheral Artery Disease

2018 ◽  
Vol 52 ◽  
pp. 147-152 ◽  
Author(s):  
Aluísio Andrade-Lima ◽  
Gabriel G. Cucato ◽  
Wagner J.R. Domingues ◽  
Antônio H. Germano-Soares ◽  
Bruno R. Cavalcante ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Peripheral Artery Disease ◽  
Calf Muscle ◽  
Walk Test ◽  
Peripheral Artery ◽  
Muscle Oxygen ◽  
Artery Disease ◽  
6 Minute Walk Test ◽  
Minute Walk

Abstract P144: One-year Change In Walking Performance And Mobility Loss In People With Peripheral Artery Disease: The Walking And Leg Circulation Study (walcs)

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Michael M Hammond ◽  
Mary M McDermott ◽  
Lu Tian ◽  
Dongxue Zhang ◽  
Lihui Zhao
Keyword(s):  
Peripheral Artery Disease ◽  
Proportional Hazards ◽  
Cox Proportional Hazards ◽  
Peripheral Artery ◽  
Cox Proportional Hazards Models ◽  
Walking Performance ◽  
Artery Disease ◽  
One Year ◽  
Minute Walk

Introduction: Peripheral artery disease (PAD) affects 10-15% of people age 65 and older, and the prevalence is expected to rise as the population ages. People with PAD have greater functional impairment and faster decline in walking performance than people without PAD. Objectives: To determine the association between 1-year change in walking performance and mobility loss. We hypothesized that greater declines in walking performance over one year would be associated with higher rates of mobility loss. Methods: Participants underwent measurement of 6-minute walk and 4-meter walking velocity at baseline, and returned yearly for repeat measurement of walking performance and assessment of mobility. Participants were categorized into tertiles based on their 1-year change in walking performance (Tertile 1: greatest decline). Mobility loss was defined as becoming newly unable to walk one-quarter mile or walk up and down 1 flight of stairs without assistance after the 1-year follow-up. We used Cox proportional hazards models to examine the association between 1-year change in walking performance and mobility loss, adjusting for potential confounders. Results: 907 participants with PAD (mean age 71 +/- 9 years, 40% female, 23% black) were included. Median follow-up time was 38 months. Participants in Tertile 1 were older (mean 73 ± 9 years compared to 71 ± 9 in Tertile 2, and 70 ± 9 in Tertile 3; p=0.0004), had lower ABI (p=0.001), and included a higher prevalence of female (42% vs. 40% in Tertile 2, and 37% in Tertile 3; p=0.36). Participants with greater decline in 6-minute walk at 1-year follow-up had higher rates of mobility loss than participants with less decline. No significant associations of change in 4-meter walking speed and mobility loss were observed (Table). Conclusion: Among people with PAD, greater 1-year declines in six-minute walk distance are associated with higher rates of mobility loss. Further study is needed to determine whether interventions that prevent decline in six-minute walk can also prevent mobility loss.

scholarly journals Perceived Versus Objective Change in Walking Ability in Peripheral Artery Disease: Results from 3 Randomized Clinical Trials of Exercise Therapy

2021 ◽  
Author(s):  
Mary M. McDermott ◽  
Lu Tian ◽  
Michael H. Criqui ◽  
Luigi Ferrucci ◽  
Philip Greenland ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Exercise Group ◽  
Control Group ◽  
Walking Ability ◽  
Peripheral Artery ◽  
Distance Score ◽  
Artery Disease ◽  
Minute Walk Distance ◽  
Minute Walk

Background In people with lower‐extremity peripheral artery disease, the effects of exercise on patient‐reported outcomes remain unclear. Methods and Results Four hundred four people with peripheral artery disease in 3 clinical trials were randomized to exercise (N=205) or a control group (N=199) and completed the 6‐minute walk and the Walking Impairment Questionnaire distance score (score 0–100, 100=best) at baseline and 6‐month follow‐up. Compared with the control group, exercise improved 6‐minute walk distance by +39.8 m (95% CI, 26.8–52.8, P <0.001) and the Walking Impairment Questionnaire distance score by +7.3 (95% CI, 2.4–12.1, P =0.003). In all, 2828 individual Walking Impairment Questionnaire distance score questions were completed at baseline and follow‐up. Among participants who perceived no change in ability to walk 1 or more distances between baseline and follow‐up, 6‐minute walk improved in the exercise group and declined in the control group (+26.8 versus −6.5 m, P <0.001). Among participants who perceived that their walking ability worsened for 1 or more distances between baseline and follow‐up, the 6‐minute walk improved in the exercise group and declined in the control group (+18.4 versus –27.3 m, P <0.001). Among participants who reported worsening calf symptoms at follow‐up, the exercise group improved and the control group declined (+28.9 versus −12.5 m, P <0.01). Conclusions In 3 randomized trials, exercise significantly improved the 6‐minute walk distance in people with peripheral artery disease, but many participants randomized to exercise reported no change or decline in walking ability. These findings suggest a significant discrepancy in objectively measured walking improvement relative to perceived walking improvement in people with peripheral artery disease. Registration Information clinicaltrials.gov. Identifiers: NCT 00106327, NCT 01408901.

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