Heavy and light chains all at once: A new immunofluorescence technique to evaluate monoclonal immunoglobulin deposits

2021 ◽  
Vol 100 (1) ◽  
pp. 22-24
Author(s):  
Dominick Santoriello ◽  
Glen S. Markowitz
Keyword(s):  
Light Chains ◽  
Immunofluorescence Technique ◽  
Monoclonal Immunoglobulin ◽  
Immunoglobulin Deposits

Hematologic Characteristics of Proliferative Glomerulonephritides With Nonorganized Monoclonal Immunoglobulin Deposits

2015 ◽  
Vol 90 (5) ◽  
pp. 587-596 ◽  
Author(s):  
Gauri Bhutani ◽  
Samih H. Nasr ◽  
Samar M. Said ◽  
Sanjeev Sethi ◽  
Fernando C. Fervenza ◽  
...  
Keyword(s):  
Monoclonal Immunoglobulin ◽  
Immunoglobulin Deposits

A monoclonal immunoglobulin G1 in which some molecules possess glycosylated light chains—I. Site of glycosylation

1981 ◽  
Vol 18 (9) ◽  
pp. 793-805 ◽  
Author(s):  
Georgina Savvidou ◽  
Michel Klein ◽  
Cathy Horne ◽  
Theo Hofmann ◽  
Keith J. Dorrington
Keyword(s):  
Light Chains ◽  
Monoclonal Immunoglobulin

scholarly journals Kidney disease associated with plasma cell dyscrasias

Blood ◽  
2010 ◽  
Vol 116 (9) ◽  
pp. 1397-1404 ◽  
Author(s):  
Eliot C. Heher ◽  
Nelson B. Goes ◽  
Thomas R. Spitzer ◽  
Noopur S. Raje ◽  
Benjamin D. Humphreys ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Plasma Cell ◽  
Molecular Mechanisms ◽  
Kidney Injury ◽  
Light Chains ◽  
Free Light Chains ◽  
Monoclonal Immunoglobulin ◽  
Plasma Cell Dyscrasias ◽  
Made In

Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.

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