Clinical significance of serum triple monoclonal components: A report of 6 cases and a review of the literature

Human tuberculosis caused by Mycobacterium microti is rare, but its prevalence and clinical significance may have been underestimated. To the best of our knowledge, 21 cases have been reported in the literature in the last decade. We report six recent pulmonary cases caused by M. microti over a period of 5 years detected in French clinical mycobacteriology laboratories of the hospital network. Our data confirm the potential of M. microti to cause clinical illness in immunocompetent patients. M. microti grew slowly from specimens, delaying the final microbiological diagnosis. Therefore, patients with tuberculosis caused by M. microti could benefit from the use of rapid diagnostic molecular techniques directly on clinical samples. From a review of the literature and this study, a classical antituberculous therapy seems effective in treating patients with M. microti disease.

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Clinical Significance of Extraintestinal Hafnia alvei Isolates from 61 Patients and Review of the Literature

Clinical Infectious Diseases ◽

10.1093/clinids/22.6.1040 ◽

1996 ◽

Vol 22 (6) ◽

pp. 1040-1045 ◽

Cited By ~ 51

Author(s):

H. Gunthard ◽

A. Pennekamp

Keyword(s):

Clinical Significance ◽

Review Of The Literature ◽

Hafnia Alvei

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Pineal Apoplexy: A Case Series and Review of the Literature

Journal of Neurological Surgery Part A Central European Neurosurgery ◽

10.1055/s-0041-1723813 ◽

2021 ◽

Author(s):

Martin Majovsky ◽

David Netuka ◽

Radim Lipina ◽

Jan Mraček ◽

Vladimír Beneš

Keyword(s):

Surgical Treatment ◽

Pineal Gland ◽

Clinical Significance ◽

Obstructive Hydrocephalus ◽

Case Series ◽

Surgical Removal ◽

Pineal Tumor ◽

Review Of The Literature ◽

Melatonin Secretion ◽

Pubmed Database

Abstract Background Pineal apoplexy is a rare condition, with unknown incidence and clinical significance. To elucidate this clinical condition, we analyzed our own case series and performed a review of the literature. Methods We enrolled all patients with a hemorrhagic pineal apoplexy who were referred to our department between January 2000 and January 2020. Hemorrhagic pineal apoplexy was defined as the presence of fluid–fluid levels inside the pineal cyst (PC) on an axial or sagittal magnetic resonance scan. In one patient, after PC apoplexy, we performed a circadian melatonin sampling from peripheral blood to determine the function of the pineal gland. The PubMed database was searched for publications using the terms “pineal” and “apoplexy.” Results Eight patients were enrolled, of which three patients underwent surgical treatment and five patients were managed conservatively. One patient was tested for circadian melatonin secretion. Results confirmed melatonin secretion with preserved physiologic circadian rhythm.Our search of the literature led us to 31 studies that comprised 30 patients with apoplectic PC, 9 with apoplectic pineal tumor, and 1 with bleeding into the normal pineal gland. Most patients presented with headache, nausea, and vomiting, less frequently with acute hydrocephalus and gaze palsy. Twenty patients with a PC underwent resection or aspiration. Two patients underwent shunt placement as the only procedure and five received both shunt and surgical removal. Six patients with a PC were observed without surgical treatment. All the nine patients with a pineal tumor were operated on. In indicated cases, four patients received radiation therapy and one received chemotherapy. Conclusion Clinical significance of hemorrhagic pineal apoplexy ranges from an asymptomatic course to rapid deterioration and death. In patients with mild symptoms, observation is indicated, whereas surgical treatment is reserved for severe cases presenting with obstructive hydrocephalus and includes cerebrospinal fluid diversion, resection of apoplectic pineal lesions, or both.

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Clinical Significance Of Findings Of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia Associated With Pulmonary Carcinoid Tumor: A Case Report And Review Of The Literature

10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3848 ◽

2011 ◽

Author(s):

Diana M. Guerra ◽

Marilynn Prince-Fiocco

Keyword(s):

Case Report ◽

Clinical Significance ◽

Carcinoid Tumor ◽

Neuroendocrine Cell ◽

Review Of The Literature ◽

Cell Hyperplasia ◽

Pulmonary Carcinoid ◽

Pulmonary Neuroendocrine Cell

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Fenestrated Anterior Cerebral Artery with Associated Arterial Anomalies

Interventional Neuroradiology ◽

10.1177/159101990801400410 ◽

2008 ◽

Vol 14 (4) ◽

pp. 441-445 ◽

Cited By ~ 6

Author(s):

S.J. Dimmick ◽

K.C. Faulder

Keyword(s):

Cerebral Aneurysm ◽

Clinical Significance ◽

Cerebral Artery ◽

Cerebral Circulation ◽

Anterior Cerebral Artery ◽

Case Reports ◽

Vascular Anomalies ◽

Review Of The Literature ◽

Aneurysm Formation ◽

Arterial Anomalies

Fenestration of the A2 segment is extremely rare. Cerebrovascular fenestration may be associated with an increased incidence of cerebral aneurysm and other vascular anomalies. Two case reports are presented which identify a fenestration of the A2 segment and other normal variations of the intra-cerebral circulation. A review of the literature has been undertaken to determine the prevalence and embryology of anterior cerebral artery fenestrations, their clinical significance and the association with aneurysm formation and other intracranial vascular anomalies.

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Microsomal Transfer Protein Inhibitors, New Approach for Treatment of Familial Hypercholesterolemia, Review of the Literature, Original Findings, and Clinical Significance

Cardiovascular Therapeutics ◽

10.1111/1755-5922.12105 ◽

2015 ◽

Vol 33 (2) ◽

pp. 71-78 ◽

Cited By ~ 8

Author(s):

Genovefa Kolovou ◽

Ioannis Vasiliadis ◽

Nikos Gontoras ◽

Vana Kolovou ◽

Georgios Hatzigeorgiou

Keyword(s):

Familial Hypercholesterolemia ◽

Clinical Significance ◽

Review Of The Literature ◽

Protein Inhibitors ◽

New Approach ◽

Transfer Protein

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Brachial branches of the medial antebrachial cutaneous nerve: A case report with its clinical significance and a short review of the literature

Journal of Neurosciences in Rural Practice ◽

10.4103/0976-3147.182772 ◽

2016 ◽

Vol 07 (03) ◽

pp. 443-446 ◽

Cited By ~ 1

Author(s):

Kapetanakis Stylianos ◽

Giatroudakis Konstantinos ◽

Pavlidis Pavlos ◽

Fiska Aliki

Keyword(s):

Differential Diagnosis ◽

Clinical Significance ◽

Rare Case ◽

Anatomical Variations ◽

Short Review ◽

Cutaneous Nerve ◽

Sensory Innervation ◽

Medial Part ◽

Review Of The Literature ◽

Surgical Operations

ABSTRACTThe medial antebrachial cutaneous nerve (MACN) is a branch of the brachial plexus with a great variation within its branches. Knowledge of these variations is critical to neurologists, hand surgeons, plastic surgeons, and vascular surgeons. The aim of this study was to search for variations of the MACN and to discuss their clinical significance. For this study, six arm cadavers from three fresh cadavers were dissected and examined to find and study possible anatomical variations of the MACN. The authors report a rare case of a variation of the MACN, in which there are four brachial cutaneous branches, before the separation to anterior (volar) and posterior (ulnar) branch, that provide sensory innervation to the medial, inferior half of the arm, in the area that is commonly innervated from the medial brachial cutaneous nerve. To our knowledge, this is the first documented case of this nerve variation. This variation should be taken into serious consideration for the differential diagnosis of patients with complaints of hypoesthesia, pain, and paresthesia and for the surgical operations in the medial part of the arm.

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