SUBDIAPHRAGMATIC EXTRANODAL LOCALIZATIONS AT DIAGNOSIS OF PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA: AN IMPRESSIVE, RARE PRESENTATION WITH NO INDEPENDENT EFFECT ON PROGNOSIS

2021 ◽  
pp. 106595
Author(s):  
Stamatis Karakatsanis ◽  
Sotirios G. Papageorgiou ◽  
Michail Michail ◽  
Maria K. Angelopoulou ◽  
Christina Kalpadakis ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Independent Effect ◽  
Rare Presentation ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Diffuse large B-cell lymphoma of the vagina in pregnancy

2020 ◽  
Vol 13 (1) ◽  
pp. e233145
Author(s):  
Nwabundo Anusim ◽  
Filip Ionescu ◽  
Olabisi Afolayan-Oloye ◽  
Susanna S Gaikazian
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Cardiac Activity ◽  
Pelvic Mass ◽  
B Cell Lymphoma ◽  
Whole Body ◽  
Rare Presentation ◽  
Whole Body Mri ◽  
Large B Cell Lymphoma ◽  
Large B Cell

A 28-year-old primigravida was evaluated for complaints of difficulty urinating and pelvic pain of 6-weeks duration. She denied fever, night sweats, weight loss or fatigue. Pelvic ultrasonography revealed a single fetal pole with cardiac activity and a 7 cm mass in the anterior vagina which encased the urethra. The diagnosis of diffuse large B-cell lymphoma germinal centre type was made on analysis of biopsied pelvic mass. Whole body MRI revealed the disease was limited to the vagina. The patient received six cycles of Rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone with significant improvement in her symptoms. Serial ultrasounds over the subsequent months showed appropriate development of the fetus. Whole body MRI after treatment showed decreased size and decreased signal of the primary pelvic mass compatible with favourable treatment response. Challenges in the management of this rare presentation of lymphoma are discussed.

scholarly journals Primary Extranodal Diffuse Large B-Cell Lymphoma of the Prostate: A Case Report

2017 ◽  
Vol 10 (1) ◽  
pp. 199-204 ◽  
Author(s):  
Daniel E. Ezekwudo ◽  
Foluso Ogunleye ◽  
Bolanle Gbadamosi ◽  
LeAnn M. Blankenship ◽  
Michael Kinoyan ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Prostate Gland ◽  
B Cell Lymphoma ◽  
Treatment Modalities ◽  
Rare Presentation ◽  
Large B Cell Lymphoma ◽  
Low Incidence ◽  
Large B Cell ◽  
Therapy Treatment

We report a case of primary diffuse large B-cell lymphoma of the prostate in a 54-year-old Caucasian male who presented with urinary retention and benign prostatic hyperplasia. We discuss the rare presentation of this disease and its clinicopathologic features and review the literature for up-to-date information on the diagnosis and clinical management. Despite the low incidence of lymphoma involving the prostate gland, it should always be considered as part of the differential diagnosis in cases of prostate gland enlargement with urinary tract obstructive symptoms resistant to medical therapy. Treatment modalities for this rare disease are also discussed.

Primary Diffuse Large B-Cell Lymphoma of the Descending Colon: A Rare Presentation

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S891-S892
Author(s):  
Bashar Sharma ◽  
Marsha Antoine ◽  
Mili Shah ◽  
Vikrant Tambe ◽  
Housam Hegazy
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Rare Presentation ◽  
Large B Cell Lymphoma ◽  
Descending Colon ◽  
Large B Cell

scholarly journals High-grade B-cell lymphoma masquerading as peritoneal lymphomatosis

2019 ◽  
Vol 12 (8) ◽  
pp. e231238 ◽  
Author(s):  
Samuel Kareff ◽  
Chao Yin ◽  
John Feigert
Keyword(s):  
Ct Scan ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
High Grade ◽  
Shortness Of Breath ◽  
Rare Presentation ◽  
Large B Cell Lymphoma ◽  
Efficacious Treatment ◽  
Large B Cell

Peritoneal lymphomatosis represents a rare presentation of any type of non-Hodgkin’s lymphoma, with relatively few cases reported in the literature. We present here the case of a 61-year-old man who originally presented with increased abdominal distention associated with shortness of breath and diaphoresis who was found to have evidence of peritoneal carcinomatosis on CT scan. Biopsy confirmed diffuse large B-cell lymphoma, and the working diagnosis was subsequently modified to peritoneal lymphomatosis. The patient was treated with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab (DA-EPOCH-R) therapy with initially good response. His course was complicated by tumour lysis syndrome. We review the limited literature discussing peritoneal lymphomatosis and discuss the importance of facilitating rapid and efficacious treatment.

scholarly journals Biological Features and Prognostic Impact of Bone Marrow Infiltration in Patients with Diffuse Large B-cell Lymphoma

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 474 ◽  
Author(s):  
Sara Alonso-Álvarez ◽  
Miguel Alcoceba ◽  
María García-Álvarez ◽  
Oscar Blanco ◽  
Marta Rodríguez ◽  
...  
Keyword(s):  
Bone Marrow ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Small Cells ◽  
Independent Effect ◽  
Prognostic Impact ◽  
Cell Of Origin ◽  
Large B Cell Lymphoma ◽  
Large B Cell

The biology and clinical impact of bone marrow (BM) infiltration in patients with diffuse large B-cell lymphoma (DLBCL) remains unclear in the rituximab era. We retrospectively analyzed 232 patients diagnosed with DLBCL at our center between 1999 and 2014. Concordant-presence of large cells similar to those of the lymph node biopsy- and discordant-infiltration by small cells forming lymphoid aggregates, lacking cytological atypia-BM infiltration was defined by histological criteria and further characterized by flow cytometry (FCM). Cell of origin (COO) was determined using Hans’ algorithm. For the clonal relationship between tumor and discordant BM, the VDJH rearrangement was analyzed. Survival analyses were restricted to 189 patients treated with rituximab and chemotherapy. Thirty-six (16%) had concordant, and 37 (16%) discordant BM infiltration. FCM described different indolent lymphomas among discordant cases, clonally related with DLBCL in 10/13 available samples. Median follow-up was 58 months. 5-year-progression-free survival (PFS) for non-infiltrated, discordant and concordant groups was 68%, 65% and 30%, respectively (p < 0.001). Combining COO and BM infiltration, patients with discordant BM and non-germinal center B-cell COO also had decreased 5-year-PFS (41.9%). In multivariate analysis, concordant BM had an independent effect on PFS (HR 2.5, p = 0.01). Five-year cumulative incidence of central nervous system (CNS) relapse was 21%, 4% and 1% in concordant, discordant and non-infiltrated groups, respectively (p < 0.001). In conclusion, concordant BM infiltration represents a subset with poor prognosis, whereas the prognostic impact of discordant BM infiltration could be limited to non-CGB cases.

scholarly journals Intravascular large B ‐cell lymphoma complicated by invasive pulmonary aspergillosis: a rare presentation

2014 ◽  
Vol 2 (2) ◽  
pp. 67-69
Author(s):  
Tamadur Mahasneh ◽  
Zinta Harrington ◽  
Jonathan Williamson ◽  
Darweesh Alkhawaja ◽  
Jo Duflou ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Invasive Pulmonary Aspergillosis ◽  
B Cell Lymphoma ◽  
Pulmonary Aspergillosis ◽  
Rare Presentation ◽  
Large B Cell Lymphoma ◽  
Large B Cell
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