High grade neuroendocrine lung tumors: Pathological characteristics, surgical management and prognostic implications

Lung Cancer ◽  
2013 ◽  
Vol 81 (3) ◽  
pp. 404-409 ◽  
Author(s):  
Bertrand Grand ◽  
Aurélie Cazes ◽  
Pierre Mordant ◽  
Christophe Foucault ◽  
Antoine Dujon ◽  
...  
Keyword(s):  
Surgical Management ◽  
Lung Tumors ◽  
High Grade ◽  
Pathological Characteristics ◽  
Prognostic Implications ◽  
Neuroendocrine Lung Tumors

scholarly journals E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors

Oncogene ◽  
2007 ◽  
Vol 26 (48) ◽  
pp. 6927-6936 ◽  
Author(s):  
C Salon ◽  
G Merdzhanova ◽  
C Brambilla ◽  
E Brambilla ◽  
S Gazzeri ◽  
...  
Keyword(s):  
Cyclin E ◽  
Lung Tumors ◽  
High Grade ◽  
Neuroendocrine Lung Tumors

scholarly journals P47.11 DLL-3 and ASCL-1 Expression Emerge as Promising Therapeutic Targets in High-Grade Neuroendocrine Lung Tumors: A Preliminary Study

2021 ◽  
Vol 16 (3) ◽  
pp. S496-S497
Author(s):  
T. Prieto ◽  
C. Machado Baldavira ◽  
A. Ab´saber ◽  
T. Takagaki ◽  
V. Capelozzi
Keyword(s):  
Therapeutic Targets ◽  
Lung Tumors ◽  
High Grade ◽  
Preliminary Study ◽  
Neuroendocrine Lung Tumors

scholarly journals CK20 and CK5/6 Immunohistochemical Staining of Urothelial Neoplasms: A Perspective

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Mohammed Akhtar ◽  
Sameera Rashid ◽  
Mohamed Ben Gashir ◽  
Noheir Mostafa Taha ◽  
Issam Al Bozom
Keyword(s):  
Mechanical Stability ◽  
Basal Layer ◽  
Low Grade ◽  
High Grade ◽  
Basal Cells ◽  
The Family ◽  
Prognostic Implications ◽  
Umbrella Cells ◽  
Proper Interpretation ◽  
Aggressive Clinical Behavior

Cytokeratins belong to the family of intermediate filaments. They are expressed in a highly specific manner in epithelial cells where they play a crucial role in the integrity and mechanical stability of the cells. Several types of cytokeratins have been described in normal as well as neoplastic urothelium. In the case of urothelial neoplasms expression of CK20 and CK5/6 has been shown in several studies to have diagnostic and prognostic implications. Thus, low-grade urothelial carcinoma manifests CK expression limited to the umbrella cells, while high-grade tumors usually have an expression in the entire thickness of the urothelium except for the basal layer. CK5/6 expression on the other hand is expressed in the basal cells in all low-grade and some high-grade urothelial carcinomas. Diffuse CK20 staining accompanied by loss of CK5/6-positive basal layer is usually associated with aggressive clinical behavior. Double staining of the slides for these cytokeratins may facilitate proper interpretation and correlation.

scholarly journals Solid-pseudopapillary tumors of the pancreas

2005 ◽  
Vol 62 (10) ◽  
pp. 763-767
Author(s):  
Darko Mirkovic ◽  
Aleksandar Karamarkovic
Keyword(s):  
Female Patient ◽  
Young Women ◽  
Diagnostic Procedures ◽  
Histopathological Analysis ◽  
High Grade ◽  
Pathological Characteristics ◽  
Rare Lesion ◽  
Grade Of Malignancy ◽  
Solid Pseudopapillary Tumors

Background. Solid-pseudopapillary tumors of the pancreas (SPT) is a very rare lesion. We presented the clinical and pathological characteristics of this tumor and reviewed the literature. Case report. We analyzed the treatment of the two female patients, aged 21 and 37 years, with this tumor. The first female patient had the tumor without involvement of the surrounding organs. The second female patient had the tumor with a high grade of malignancy which invaded blood vessels. We performed in both patients splenohemipancreatectomy, and then we reported the pathological characteristics of the tumors. We didn't find recidive in the observed postoperative follow-up of 4, and 6 years, respectively. Conclusion. SPT is a rare tumor of the pancreas that is diagnosed primarily in young women. The prognosis after surgical treatment was excellent. The histopathological analysis is the main procedure in establishing diagnosis, regardless the most recent diagnostic procedures.

Surgical management of high-grade spondylolisthesis

2020 ◽  
Vol 32 (3) ◽  
pp. 100809
Author(s):  
Andrew J. Trontis ◽  
Mesfin A. Lemma
Keyword(s):  
Surgical Management ◽  
High Grade
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