Background:
Literature data on the synthesis and structure of oximes of nucleosides and related nitrogenous
bases from pyrimidine and purine were reviewed. Synthesis of novel heterocyclic systems from nucleoside
oximes related pyrimidine oximes was described. The biological activity of derivatives of nucleoside
and nitrogenous base oximes was also reviewed.
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Objective: The review focuses on the recent progress in the area of nucleoside oxime synthesis, reactions and
biological activity.
Conclusion:
In summary, literature data on the synthesis and structure of oximes of nucleosides and related
nitrogenous bases derived from pyrimidine, which play an important role in the biological processes, were reviewed.
Synthesis of novel heterocyclic systems from nucleoside oximes related pyrimidine oximes was described.
The biological activity of derivatives of nucleoside and nucleotide oximes was also reviewed. The
studied class of compounds show a wide range of imino-amino and imino-nitroso tautomerism, which was investigated
in the presented literature by 1H, 13C and 15N NMR spectroscopy methods. Also, according to the
authors point of view, due to imino-amino and/or imino-nitroso tautomerism the nucleoside oximes show interesting
activity. Most of the compounds exhibit biological activity characteristic of not only oxime derivatives,
but also activity of hydroxylamines or nitroso compounds.
