Mathematical modeling of transdermal drug delivery using microneedle

2022 ◽  
Author(s):  
Abdelhakim Benslimane ◽  
Sofiane Fatmi ◽  
Lamia Taouzinet ◽  
Dalila Hammiche
Keyword(s):  
Mathematical Modeling ◽  
Drug Delivery ◽  
Transdermal Drug Delivery

On Mathematical Modeling of Dermal and Transdermal Drug Delivery

1998 ◽  
Vol 87 (7) ◽  
pp. 873-879 ◽  
Author(s):  
R. Manitz ◽  
W. Lucht ◽  
K. Strehmel ◽  
R. Weiner ◽  
R. Neubert
Keyword(s):  
Mathematical Modeling ◽  
Drug Delivery ◽  
Transdermal Drug Delivery

Evaluation of transdermal drug-delivery system of capsaicin

2017 ◽  
Author(s):  
A Uzunovic ◽  
S Pilipovic ◽  
A Sapcanin ◽  
Z Ademovic
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Transdermal Drug Delivery System

Enhancement of Transdermal Drug Delivery: Chemical and Physical Approaches

2000 ◽  
Vol 17 (6) ◽  
pp. 64 ◽  
Author(s):  
Charles S. Asbill ◽  
Ayman F. El-Kattan ◽  
Bozena Michniak
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

Microneedles for transdermal drug delivery: a minireview

10.2741/2794 ◽  
2008 ◽  
Vol 13 (13) ◽  
pp. 1711 ◽  
Author(s):  
Jo Vandervoort
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery
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