Diminished ovarian reserve and primary ovarian insufficiency in two women with celiac disease. Is there a link?

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 163
Author(s):  
Pantelis Messaropoulos ◽  
Vassilia Hatzidakis ◽  
Christina Tzouma ◽  
Maria Oikonomou ◽  
Spyridoula Neofytou ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Ovarian Reserve ◽  
Primary Ovarian Insufficiency ◽  
Diminished Ovarian Reserve ◽  
Ovarian Insufficiency

scholarly journals In vitro activation of ovarian cortex and autologous transplantation: A novel approach to primary ovarian insufficiency and diminished ovarian reserve

2020 ◽  
Vol 2020 (4) ◽  
Author(s):  
L Devenutto ◽  
R Quintana ◽  
T Quintana
Keyword(s):  
Ovarian Reserve ◽  
Conflicts Of Interest ◽  
Autologous Transplantation ◽  
Primary Ovarian Insufficiency ◽  
Diminished Ovarian Reserve ◽  
Ovarian Insufficiency ◽  
Primordial Follicles ◽  
Ovarian Cortex ◽  
In Vitro Activation

Abstract BACKGROUND Primary ovarian insufficiency (POI) and diminished ovarian reserve are two conditions that affect women’s fertility. Oocyte donation remains an option for these patients; however, the development of certain novel technologies, such as in vitro activation of ovarian cortex (IVA), enables the possibility of activating the pool of resting primordial follicles, increasing the chance of pregnancy. OBJECTIVE AND RATIONALE Here, we review the main pathways (PI3K and Hippo signaling) that govern the activation of primordial follicles and its application through the development of culture systems that support ovarian cortex for autologous transplantation. We also review the available data from case reports regarding outcomes of pregnancy and live birth rates with IVA. SEARCH METHODS A PubMed search was conducted using the PubMed-NCBI database to identify literature pertinent to the pathways involved in the activation of primordial follicles and the outcomes of IVA techniques from 2013 to the present. OUTCOMES Women with POI have around a 5% chance of spontaneous pregnancy. Recently, novel techniques involving the activation of primordial follicles through molecular pathways have been developed, thus increasing the odds of these patients. More recently, the introduction of a drug-free IVA technique has shown to increase the number of antral follicles with successful oocyte maturation after gonadotropin treatment, reaching pregnancy rates over 30%, either through spontaneous conception or by the implementation of assisted reproductive technology. LIMITATIONS The evidence of this review is based on a few small series, so data should be interpreted with caution, and only randomized controlled trials could estimate the real magnitude and success of the procedure. REASONS FOR CAUTION IVA technique remains an experimental strategy, with limited available data and the requirement of invasive procedures. Moreover, possible carcinogenic effects not yet determined after transplantation require special caution. WIDER IMPLICATIONS In view of the results achieved, IVA could provide a promising option for the preservation of fertility in some cancer patients and prepuberal girls where the only alternative is tissue cryopreservation. STUDY FUNDING/COMPETING INTERESTS The authors received no specific funding for this work and declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

scholarly journals In Vitro Follicular Activation and Stem Cell Therapy as a Novel Treatment Strategies in Diminished Ovarian Reserve and Primary Ovarian Insufficiency

2021 ◽  
Vol 11 ◽  
Author(s):  
Francesc Fàbregues ◽  
Janisse Ferreri ◽  
Marta Méndez ◽  
Josep María Calafell ◽  
Jordi Otero ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Therapeutic Option ◽  
Treatment Strategies ◽  
Ovarian Response ◽  
Primary Ovarian Insufficiency ◽  
Diminished Ovarian Reserve ◽  
Hippo Signaling ◽  
Ovarian Insufficiency ◽  
Novel Treatment Strategies

Usually poor ovarian response (POR) to gonadotropins reflects a diminished ovarian reserve (DOR) that gives place to few recruitable follicles despite aggressive stimulation. The reduction in the quantity and quality of the oocytes with advanced age is physiological. However, some women experience DOR much earlier and become prematurely infertile, producing an accelerated follicular depletion towards primary ovarian insufficiency (POI). Up to now, egg donation has been commonly used to treat their infertility. In the last thirty years, specialists in assisted reproduction have focused their attention on the final stages of folliculogenesis, those that depend on the action of gonadotrophins. Nevertheless, recently novel aspects have been known to act in the initial phases, with activating and inhibiting elements. In vitro activation (IVA) combining the in vitro stimulation of the ovarian Akt signaling pathway in ovarian cortex fragments with a method named Hippo-signaling disruption. Later, a simplification of the technique designated Drug-Free IVA have shown encouraging results in patients with POI. Another innovative therapeutic option in these patients is the infusion of bone marrow-derived stem cells (BMDSC) in order to supply an adequate ovarian niche to maintain and/or promote follicular rescue in patients with impaired or aged ovarian reserves. In this review, for the first time, both therapeutic options are addressed together in a common clinical setting. The aim of this review is to analyze the physiological aspects on which these innovative techniques are based; the preliminary results obtained up to now; and the possible therapeutic role that they may have in the future with DOR and POI patients.

Analysis of NR5A1 in 142 patients with premature ovarian insufficiency, diminished ovarian reserve, or unexplained infertility

Maturitas ◽  
2020 ◽  
Vol 131 ◽  
pp. 78-86 ◽  
Author(s):  
Sylvie Jaillard ◽  
Rajini Sreenivasan ◽  
Marion Beaumont ◽  
Gorjana Robevska ◽  
Christèle Dubourg ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Unexplained Infertility ◽  
Diminished Ovarian Reserve ◽  
Premature Ovarian Insufficiency ◽  
Ovarian Insufficiency

P–645 Abnormal thyroid hormone levels are associated with biochemical primary ovarian insufficiency and low ovarian reserve: a cross-sectional study

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
C Feng
Keyword(s):  
Thyroid Hormones ◽  
Ovarian Reserve ◽  
Thyroid Dysfunction ◽  
Cross Sectional Study ◽  
Primary Ovarian Insufficiency ◽  
Reproductive Age ◽  
Sectional Study ◽  
Ovarian Insufficiency ◽  
Cross Sectional ◽  
Chi Square Analysis

Abstract Study question To address whether there was a correlation between thyroid parameters and primary ovarian insufficiency. Summary answer Thyroid dysfunction was related with bPOI and LOR. What is known already In our daily clinical work, there seems to be a link between thyroid disease and POI. A recent study reported that subclinical hypothyroidism was associated with lower ovarian reserve during later reproductive age. Animal studies demonstrated that thyroid hormones played important roles in ovarian functions, and both maternal hypothyroidism and hyperthyroidism were related with reduced primordial, primary and secondary follicle number in rats. However, others reported that thyroid autoimmunity (TAI) and hypothyroidism were not associated with DOR. In all, accumulative animal and epidemiological studies indicated the connection between thyroid function and ovarian reserve, but the results were still inconsistent. Study design, size, duration This is a cross-sectional study with consecutive women performed ovarian reserve assessment and thyroid test in the Second Hospital of Zhejiang University School of Medicine from April 2016 to March 2019. A total of 2109 women were included, with 111 with bPOI and 1771 without bPOI. To exclude the influence of age the participants were categorized into low ovarian reserve (LOR) and non-LOR groups based on age-specific AMH, including 78 LOR and 2031 non-LOR. Participants/materials, setting, methods At the outpatient, a doctor carried out an interview, recorded age, body mass index (BMI), past history, and current treatment, and made a diagnosis. Serum AMH, FSH, TPOAb, TgAb, Tg, TT3, FT3, TT4, FT4, and TSH levels were measured with electrochemiluminescence method. Main results and the role of chance TT3, FT3, FT4 was significantly positively correlated with serum AMH level. Further logistic regression analysis found that abnormal TT3, FT3 and TT4 levels were related to increased risks of bPOI and LOR. Chi-square analysis also proved that the incidence of abnormal TT3, FT3 and TT4 increased significantly in women with bPOI or LOR. The incidence of bPOI and LOR increased significantly in women with 2 or 3 abnormal thyroid hormones. The above analyses demonstrate in multiple aspects that thyroid dysfunction is related with decreased ovarian reserve. Limitations, reasons for caution Since this is a retrospective cross-sectional study, we only got the correlation between factors, and we could not achieve causal relationship. Further prospective cohort or randomized controlled trial (RCT) studies are required to make the results more robust. Wider implications of the findings: The present study demonstrated that thyroid dysfunction was related with bPOI and LOR. It might be thyroid hormones, not TSH or thyroid antibodies, played the major role in ovarian reserve impairment. The treatment of euthyroxine may improve the ovarian reserve function. Trial registration number Not applicable

Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency

2012 ◽  
Vol 8 (6) ◽  
pp. 331-341 ◽  
Author(s):  
Jenny A. Visser ◽  
Izaäk Schipper ◽  
Joop S. E. Laven ◽  
Axel P. N. Themmen
Keyword(s):  
Ovarian Reserve ◽  
Primary Ovarian Insufficiency ◽  
Ovarian Insufficiency
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