Safety and Efficacy of Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection in Patients With Cancer Treated With Cytotoxic Chemotherapy: A Single-Institution Retrospective Case Series

2017 ◽  
Vol 92 (11) ◽  
pp. 1617-1624 ◽  
Author(s):  
Mehrdad Hefazi ◽  
Mrinal M. Patnaik ◽  
William J. Hogan ◽  
Mark R. Litzow ◽  
Darrell S. Pardi ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Case Series ◽  
Fecal Microbiota ◽  
Cytotoxic Chemotherapy ◽  
Single Institution ◽  
Retrospective Case ◽  
Fecal Microbiota Transplant ◽  
Safety And Efficacy ◽  
Patients With Cancer ◽  
Recurrent Clostridium Difficile Infection

Self-Administered Home Series Fecal “Minitransplants” for Recurrent Clostridium difficile Infection on a Rectal Remnant

2015 ◽  
Vol 24 (4) ◽  
pp. 531-533 ◽  
Author(s):  
Daniel Popa ◽  
Mihaela Laszlo ◽  
Lidia Ciobanu ◽  
Elena Ucenic ◽  
Manuela Mihalache ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clostridium Difficile ◽  
Clostridium Difficile Infection ◽  
Toxic Megacolon ◽  
Fecal Microbiota ◽  
Recurrent Infections ◽  
Resonance Imaging ◽  
Vaginal Infection ◽  
Fecal Microbiota Transplant ◽  
Recurrent Clostridium Difficile Infection

A fecal microbiota transplant has proved to be an extremely effective method for patients with recurrent infections with Clostridium difficile. We present the case of a 65-year-old female patient with multiple Clostridium difficile infection (CDI) relapses on the rectal remnant, post-colectomy for a CDI-related toxic megacolon. The patient also evidenced associated symptomatic Clostridium difficile vaginal infection. She was successfully treated with serial fecal “minitransplants” (self-administered at home) and metronidazole ovules.Abbreviations: GI: gastrointestinal; MRI: magnetic resonance imaging; CDI: Clostridium difficile infection; FMT: fecal microbiota transplant.

scholarly journals Current challenges in the treatment of severe Clostridium difficile infection: early treatment potential of fecal microbiota transplantation

2017 ◽  
Vol 10 (4) ◽  
pp. 373-381 ◽  
Author(s):  
Yvette H. van Beurden ◽  
Max Nieuwdorp ◽  
Pablo J. E. J. van de Berg ◽  
Chris J. J. Mulder ◽  
Abraham Goorhuis
Keyword(s):  
Clostridium Difficile ◽  
Antibiotic Treatment ◽  
Clostridium Difficile Infection ◽  
Fecal Microbiota Transplantation ◽  
Case Reports ◽  
Case Series ◽  
Fecal Microbiota ◽  
Curative Treatment ◽  
Bowel Surgery ◽  
Recurrent Clostridium Difficile Infection

Fecal microbiota transplantation (FMT) is a very effective treatment for recurrent Clostridium difficile infection (CDI). Less is known about the application of FMT as a curative treatment of severe or complicated CDI. In this review, we present and discuss evidence supporting the curative use of FMT in severe or complicated CDI. We performed a literature search in PubMed and Embase for studies on the curative use of FMT in severe or complicated CDI. In addition, we describe a patient with severe CDI not responding to initial antibiotic treatment, who was successfully treated with curative FMT. We found 23 reports (12 case reports; 11 case series) about FMT as treatment for severe or complicated CDI. The patients described all had severe or complicated CDI, did not respond to conventional CDI antibiotic treatment and received FMT as last resort treatment. Patients were treated with (sequential) FMT, whether or not followed by additional antibiotic treatment for CDI. FMT, with or without additional antibiotic CDI treatment, appears to be a promising curative treatment option in patients with severe and complicated CDI, or only complicated CDI, who do not respond sufficiently to conventional antibiotic treatment. Treatment with FMT should be considered in these patients before proceeding to emergency bowel surgery.

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