Thermal anemometric assessment of coronary flow reserve with a pressure-sensing guide wire: An in vitro evaluation

2011 ◽  
Vol 33 (6) ◽  
pp. 684-691 ◽  
Author(s):  
Arjen van der Horst ◽  
Maartje C.F. Geven ◽  
Marcel C.M. Rutten ◽  
Nico H.J. Pijls ◽  
Frans N. van de Vosse
Keyword(s):  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Guide Wire ◽  
Pressure Sensing ◽  
In Vitro Evaluation ◽  
Flow Reserve

Delineating the guide-wire flow obstruction effect in assessment of fractional flow reserve and coronary flow reserve measurements

2005 ◽  
Vol 289 (1) ◽  
pp. H392-H397 ◽  
Author(s):  
Abhijit Sinha Roy ◽  
Rupak K. Banerjee ◽  
Lloyd H. Back ◽  
Martin R. Back ◽  
Saeb Khoury ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Flow Reserve ◽  
Fractional Flow Reserve ◽  
Coronary Flow ◽  
Guide Wire ◽  
Microvascular Disease ◽  
Fractional Flow ◽  
Flow Reserve ◽  
Mean Pressure ◽  
Distal Perfusion

Hemodynamic analysis was conducted to determine uncertainty in clinical measurements of coronary flow reserve (CFR) and fractional flow reserve (FFR) over pathophysiological conditions in a patient group with coronary artery disease during angioplasty. The vasodilation-distal perfusion pressure (CFR-p̃rh) curve was obtained for 0.35- and 0.46-mm guide wires. Our hypothesis is that a guide wire spanning the lesions elevates the pressure gradient and reduces the flow during hyperemic measurements. Maximal CFR-p̃rh was uniquely determined by the intersection of measured CFR and calculated p̃rh of native and residual epicardial lesions in patients without microvascular disease, during angioplasty. Extrapolation of the linear curve gave a zero-coronary flow mean pressure (p̃zf) of ∼20 mmHg and a corresponding p̃rh of 55 mmHg in the native lesions, which coincided with the level that causes ischemia in human hearts. On this linear curve, values of CFR and FFRmyo (pathophysiological condition) and CFRg and FFRmyog (in the presence of the guide wire) were obtained in native and residual lesions. A strong linear correlation was found between CFR and CFRg [CFR = CFRg × 0.689 + 1.271 ( R2 = 0.99) for 0.46 mm and CFR = CFRg × 0.757 + 1.004 ( R2 = 0.99) for 0.35 mm] and between FFRmyo and FFRmyog [FFRmyo = FFRmyog × 0.737 + 0.263 ( R2 = 0.99) for 0.46 mm and FFRmyo = FFRmyog × 0.790 + 0.210 ( R2 = 0.99) for 0.35 mm]. This study establishes a strong correlation between CFR and CFRg and between FFRmyo and FFRmyog, which could be used to obtain the true state of occlusion in the coronary artery during angioplasty.

scholarly journals Analysis of coronary flow reserve using Doppler guide wire in patients with chronic renal replacement therapy

1998 ◽  
Vol 31 (5) ◽  
pp. 927-932
Author(s):  
Masanori Utsunomiya ◽  
Makoto Ohta ◽  
Kenichi Sugimoto ◽  
Tadashi Tamura ◽  
Masuteru Ono ◽  
...  
Keyword(s):  
Renal Replacement Therapy ◽  
Replacement Therapy ◽  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Guide Wire ◽  
Flow Reserve

Comparison between Nicorandil and Adenosine in the Measurement of Coronary Flow Reserve Using a Doppler Guide Wire

2002 ◽  
Vol 32 (5) ◽  
pp. 391 ◽  
Author(s):  
Hae Ok Jung ◽  
Ki Bae Seung ◽  
Pum Joon Kim ◽  
Sang Hyun Ihm ◽  
Dong Heun Kang ◽  
...  
Keyword(s):  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Guide Wire ◽  
Flow Reserve

New method to measure coronary velocity and coronary flow reserve

2011 ◽  
Vol 301 (1) ◽  
pp. H21-H28 ◽  
Author(s):  
Z.-D. Zhang ◽  
M. Svendsen ◽  
J. S. Choy ◽  
A. K. Sinha ◽  
Y. Huo ◽  
...  
Keyword(s):  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Mean Difference ◽  
Saline Injection ◽  
Conductance Catheter ◽  
Flow Probe ◽  
Cross Sectional ◽  
Flow Reserve ◽  
The Mean

Coronary flow reserve (CFR) is an important index of coronary microcirculatory function. The objective of this study was to validate the reproducibility and accuracy of intravascular conductance catheter-based method for measurements of baseline and hyperemic coronary flow velocity (and hence CFR). The absolute coronary blood velocity was determined by measuring the time of transit of a saline injection between two pairs of electrodes (known distance) on a conductance catheter during a routine saline injection without the need for reference flow. In vitro validation was made in the velocity range of 5 to 70 cm/s in reference to the volume collection method. In 10 swine, velocity measurements were compared with those from a flow probe in coronary arteries at different CFR attained by microsphere embolization. In vitro, the mean difference between the proposed method and volume collection was 0.7 ± 1.34 cm/s for steady flow and −0.77 ± 2.22 cm/s for pulsatile flow. The mean difference between duplicate measurements was 0 ± 1.4 cm/s. In in vivo experiments, the flow (product of velocity and lumen cross-sectional area that is also measured by the conductance catheter) was determined in both normal and stenotic vessels and the mean difference between the proposed method and flow probe was −1 ± 12 ml/min (flow ranged from 10 to 130 ml/min). For CFR, the mean difference between the two methods was 0.06 ± 0.28 (range of 1 to 3). Our results demonstrate the reproducibility and accuracy of velocity and CFR measurements with a conductance catheter by use of a standard saline injection. The ability of the combined measurement of coronary lumen area (as previously validated) and current velocity and CFR measurements provides an integrative diagnostic tool for interventional cardiology.

Correlations between coronary flow reserve measured with a Doppler guide wire and treadmill exercise testing

1997 ◽  
Vol 134 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Douglas S. Schulman ◽  
David Lasorda ◽  
Tony Farah ◽  
Peter Soukas ◽  
Nathaniel Reichek ◽  
...  
Keyword(s):  
Coronary Flow Reserve ◽  
Exercise Testing ◽  
Coronary Flow ◽  
Treadmill Exercise ◽  
Guide Wire ◽  
Flow Reserve ◽  
Treadmill Exercise Testing
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