A single-group trial of end-stage patients with anthroponotic cutaneous leishmaniasis: Levamisole in combination with Glucantime in field and laboratory models

Abstract Background: An on body personal lift assist device (OBPLAD) is a non-motorized, passive device in which the elastic elements act as an external muscle power generator to assist lifting thereby offloading the trunk muscles. Though there is enough evidence for the use of OBPLAD generated through laboratory studies, we found a scarcity of evidence on the use of OBPLAD in real-life work settings, especially in the Indian population. This study investigates the effect of the Jaipur belt, an OBPLAD, on trunk muscle fatiguability while performing repetitive lifting task in manual material handlers. Methods:70 subjects engaged in manual material handling were recruited from industries in and around Mangalore, Karnataka in this non-randomized single group trial. Subjects were made to perform a repetitive lifting task over a period of 15 minutes with and without an OBPLAD. Electromyographic data were recorded from rectus abdominis, transverse abdominis, quadratus lumborum, and erector spinae from either side of the body, and the onset of fatigue was deduced from the changes in electromyographic parameters. Results: We found a delay in the onset of fatigue in all the muscle groups studied while the lift was performed wearing the Jaipur belt. However, the findings were statistically significant only for right erector spinae, right rectus abdominis, left transverse abdominis, and left quadratus lumborum. It was found also that number of repetitions as well as time for which a task would be sustained were both found to be significantly better wearing an OBPLAD.Conclusion: The findings of the study imply that the Jaipur belt could potentially delay the onset of fatigue in the trunk muscles while performing repetitive lifting task and hence, is proved to be useful in the prevention of fatigue-related musculoskeletal disorders of the lower back.CTRI Registration date: 10/02/2020 Trial registration number: CTRI/2020/02/023219

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Single-group trial of an Internet-delivered insomnia intervention among higher-intensity family caregivers: Rationale and mixed-methods study protocol (Preprint)

JMIR Research Protocols ◽

10.2196/34792 ◽

2021 ◽

Author(s):

Kelly M. Shaffer ◽

Lee M. Ritterband ◽

Wen You ◽

Daniel J. Buysse ◽

Meghan K. Mattos ◽

...

Keyword(s):

Mixed Methods ◽

Family Caregivers ◽

Study Protocol ◽

Mixed Methods Study ◽

Single Group ◽

Group Trial

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Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100166397 ◽

1996 ◽

Vol 54 ◽

pp. 786-787

Author(s):

Chi-Ming Wei ◽

Margarita Bracamonte ◽

Shi-Wen Jiang ◽

Richard C. Daly ◽

Christopher G.A. McGregor ◽

...

Keyword(s):

Nitric Oxide ◽

Heart Failure ◽

Nitric Oxide Synthase ◽

Endothelial Nitric Oxide Synthase ◽

Cardiac Tissues ◽

Mammalian Tissues ◽

End Stage Heart Failure ◽

End Stage ◽

Oxide Synthase ◽

Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

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