scholarly journals Relapse Prevention in Ulcerative Colitis by Plant-Based Diet Through Educational Hospitalization: A Single-Group Trial

2018 ◽  
Author(s):  
Mitsuro Chiba
Keyword(s):  
Ulcerative Colitis ◽  
Relapse Prevention ◽  
Single Group ◽  
Group Trial

Prebiotics and Probiotics in Inflammatory Bowel Disease: Where are we now and where are we going?

2020 ◽  
Vol 15 (3) ◽  
pp. 216-233 ◽  
Author(s):  
Maliha Naseer ◽  
Shiva Poola ◽  
Syed Ali ◽  
Sami Samiullah ◽  
Veysel Tahan
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Clinical Trials ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Adverse Effects ◽  
Bowel Disease ◽  
Relapse Prevention ◽  
Remission Induction ◽  
Inflammatory Bowel

The incidence, prevalence, and cost of care associated with diagnosis and management of inflammatory bowel disease are on the rise. The role of gut microbiota in the causation of Crohn's disease and ulcerative colitis has not been established yet. Nevertheless, several animal models and human studies point towards the association. Targeting intestinal dysbiosis for remission induction, maintenance, and relapse prevention is an attractive treatment approach with minimal adverse effects. However, the data is still conflicting. The purpose of this article is to provide the most comprehensive and updated review on the utility of prebiotics and probiotics in the management of active Crohn’s disease and ulcerative colitis/pouchitis and their role in the remission induction, maintenance, and relapse prevention. A thorough literature review was performed on PubMed, Ovid Medline, and EMBASE using the terms “prebiotics AND ulcerative colitis”, “probiotics AND ulcerative colitis”, “prebiotics AND Crohn's disease”, “probiotics AND Crohn's disease”, “probiotics AND acute pouchitis”, “probiotics AND chronic pouchitis” and “prebiotics AND pouchitis”. Observational studies and clinical trials conducted on humans and published in the English language were included. A total of 71 clinical trials evaluating the utility of prebiotics and probiotics in the management of inflammatory bowel disease were reviewed and the findings were summarized. Most of these studies on probiotics evaluated lactobacillus, De Simone Formulation or Escherichia coli Nissle 1917 and there is some evidence supporting these agents for induction and maintenance of remission in ulcerative colitis and prevention of pouchitis relapse with minimal adverse effects. The efficacy of prebiotics such as fructooligosaccharides and Plantago ovata seeds in ulcerative colitis are inconclusive and the data regarding the utility of prebiotics in pouchitis is limited. The results of the clinical trials for remission induction and maintenance in active Crohn's disease or post-operative relapse with probiotics and prebiotics are inadequate and not very convincing. Prebiotics and probiotics are safe, effective and have great therapeutic potential. However, better designed clinical trials in the multicenter setting with a large sample and long duration of intervention are needed to identify the specific strain or combination of probiotics and prebiotics which will be more beneficial and effective in patients with inflammatory bowel disease.

A single-group trial of end-stage patients with anthroponotic cutaneous leishmaniasis: Levamisole in combination with Glucantime in field and laboratory models

2019 ◽  
Vol 128 ◽  
pp. 162-170 ◽  
Author(s):  
Mehdi Bamorovat ◽  
Iraj Sharifi ◽  
Alireza Fekri ◽  
Alireza Keyhani ◽  
Mohammad Reza Aflatoonian ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Single Group ◽  
End Stage ◽  
Laboratory Models ◽  
Group Trial

scholarly journals S1054 Preliminary Results From the Ulcerative Colitis Relapse Prevention Study (UCRPT)

2010 ◽  
Vol 138 (5) ◽  
pp. S-168
Author(s):  
Laurie Keefer ◽  
Jennifer L. Kiebles ◽  
Terrence A. Barrett
Keyword(s):  
Ulcerative Colitis ◽  
Relapse Prevention ◽  
Prevention Study ◽  
Preliminary Results

scholarly journals The Effect of an on Body Personal Lift Assist Device (Jaipur Belt) on Trunk Muscle Fatiguability During a Repetitive Lifting Task in Manual Material Handlers – A Non-Randomized Single-Group Trial

2021 ◽  
Author(s):  
Betty Thomas ◽  
Shyam Krishnan K ◽  
Ashish John Prabhakar ◽  
Megha M. Nayak ◽  
Charu Eapen
Keyword(s):  
Erector Spinae ◽  
Trunk Muscles ◽  
Single Group ◽  
Assist Device ◽  
Repetitive Lifting ◽  
Quadratus Lumborum ◽  
Transverse Abdominis ◽  
Lift Assist ◽  
Lifting Task ◽  
Group Trial

Abstract Background: An on body personal lift assist device (OBPLAD) is a non-motorized, passive device in which the elastic elements act as an external muscle power generator to assist lifting thereby offloading the trunk muscles. Though there is enough evidence for the use of OBPLAD generated through laboratory studies, we found a scarcity of evidence on the use of OBPLAD in real-life work settings, especially in the Indian population. This study investigates the effect of the Jaipur belt, an OBPLAD, on trunk muscle fatiguability while performing repetitive lifting task in manual material handlers. Methods:70 subjects engaged in manual material handling were recruited from industries in and around Mangalore, Karnataka in this non-randomized single group trial. Subjects were made to perform a repetitive lifting task over a period of 15 minutes with and without an OBPLAD. Electromyographic data were recorded from rectus abdominis, transverse abdominis, quadratus lumborum, and erector spinae from either side of the body, and the onset of fatigue was deduced from the changes in electromyographic parameters. Results: We found a delay in the onset of fatigue in all the muscle groups studied while the lift was performed wearing the Jaipur belt. However, the findings were statistically significant only for right erector spinae, right rectus abdominis, left transverse abdominis, and left quadratus lumborum. It was found also that number of repetitions as well as time for which a task would be sustained were both found to be significantly better wearing an OBPLAD.Conclusion: The findings of the study imply that the Jaipur belt could potentially delay the onset of fatigue in the trunk muscles while performing repetitive lifting task and hence, is proved to be useful in the prevention of fatigue-related musculoskeletal disorders of the lower back.CTRI Registration date: 10/02/2020 Trial registration number: CTRI/2020/02/023219

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