The vaginal and fecal microbiota of a murine cervical carcinoma model under synergistic effect of 17β-Estradiol and E7 oncogene expression

2021 ◽  
Vol 152 ◽  
pp. 104763
Author(s):  
Fernando Hernández-Quiroz ◽  
Selvasankar Murugesan ◽  
Cristina Velazquez-Martínez ◽  
Loan Edel Villalobos-Flores ◽  
Otoniel Maya-Lucas ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Cervical Carcinoma ◽  
Fecal Microbiota ◽  
Oncogene Expression ◽  
17Β Estradiol ◽  
E7 Oncogene

E6 and E7 oncogene expression by human papilloma virus (HPV) and the aggressive behavior of recurrent laryngeal papillomatosis (RLP)

2006 ◽  
Vol preprint (2007) ◽  
pp. 1
Author(s):  
Bahig Shehata ◽  
Kristen Otto ◽  
Steven Sobol ◽  
Christina Stockwell ◽  
Cora Foulks ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Aggressive Behavior ◽  
Laryngeal Papillomatosis ◽  
Papilloma Virus ◽  
Oncogene Expression ◽  
E6 And E7 ◽  
E7 Oncogene

Differences in HPV 16- and HPV 18 E6/E7 oncogene expression between in situ and invasive adenocarcinomas of the cervix uteri

2000 ◽  
Vol 437 (5) ◽  
pp. 491-500 ◽  
Author(s):  
Sabine Riethdorf ◽  
Lutz Riethdorf ◽  
Karin Milde-Langosch ◽  
Tjoung-Won Park ◽  
Thomas Löning
Keyword(s):  
Cervix Uteri ◽  
Hpv 16 ◽  
Oncogene Expression ◽  
Hpv 18 ◽  
E7 Oncogene

scholarly journals Human Papillomavirus Genotype Distribution and E6/E7 Oncogene Expression in Turkish Women with Cervical Cytological Findings

2014 ◽  
Vol 15 (9) ◽  
pp. 3997-4003 ◽  
Author(s):  
Seda Tezcan ◽  
Didem Ozgur ◽  
Mahmut Ulger ◽  
Gonul Aslan ◽  
Iclal Gurses ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Genotype Distribution ◽  
Turkish Women ◽  
Oncogene Expression ◽  
E7 Oncogene

Activity of Andrographolide and Its Derivatives on HPV16 Pseudovirus Infection and Viral Oncogene Expression in Cervical Carcinoma Cells

2015 ◽  
Vol 67 (4) ◽  
pp. 687-696 ◽  
Author(s):  
Tipaya Ekalaksananan ◽  
Waree Sookmai ◽  
Supada Fangkham ◽  
Chamsai Pientong ◽  
Chantana Aromdee ◽  
...  
Keyword(s):  
Cervical Carcinoma ◽  
Carcinoma Cells ◽  
Viral Oncogene ◽  
Oncogene Expression

Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells

2006 ◽  
Vol 16 (3) ◽  
pp. 1321-1329 ◽  
Author(s):  
E.-K. YIM ◽  
S.B. LEE ◽  
K.-H. LEE ◽  
C.-J. KIM ◽  
J.-S. PARK
Keyword(s):  
Synergistic Effect ◽  
Cervical Carcinoma ◽  
Carcinoma Cells

scholarly journals Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions.

1994 ◽  
Vol 68 (5) ◽  
pp. 2811-2821 ◽  
Author(s):  
M von Knebel Doeberitz ◽  
C Rittmüller ◽  
F Aengeneyndt ◽  
P Jansen-Dürr ◽  
D Spitkovsky
Keyword(s):  
Cervical Carcinoma ◽  
Carcinoma Cells ◽  
Oncogene Expression

Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells

2006 ◽  
Vol 16 (3) ◽  
pp. 1321-1329 ◽  
Author(s):  
E. K. Yim ◽  
S. B. Lee ◽  
K. H. Lee ◽  
C. J. Kim ◽  
J. S. Park
Keyword(s):  
Cervical Cancer ◽  
Synergistic Effect ◽  
Cervical Carcinoma ◽  
Carcinoma Cells ◽  
Antiproliferative Effect ◽  
Apoptotic Pathway ◽  
Two Dimensional Gel Electrophoresis ◽  
Human Carcinoma ◽  
Apoptosis Pathway

5-Fluorouracil (5-FU) is currently being used as an anticancer drug to reduce tumor bulk in order to increase the operability rate and postoperative survival in patients with cervical cancer, which has been combined with cisplatin (CP) because of its superior activities observed in human carcinoma cells. However, the combined anticancer effect of 5-FU and CP in cervical carcinoma cells is poorly understood. Therefore, we conducted a study to investigate whether anticancer drugs 5-FU and CP may exhibit the combined antiproliferative effect in cervical carcinoma cells. Using proteomics analysis, including two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS), we investigated the antiproliferative effect–related proteins after treatment with 5-FU and/or CP. Our experiments showed that the combination of 5-FU and CP engaged both the apoptotic pathways: the membrane death receptor–mediated apoptosis pathway and the mitochondrial apoptotic pathway. Moreover, the combination of 5-FU and CP resulted in remarkable increasing susceptibility to apoptosis. We suggest that the combination of 5-FU and CP suppresses the growth of cervical carcinoma cells by synergistic effect with the induction of apoptosis. In vitro synergistic effect of 5-FU and CP supports the basis of the clinical application of the combination chemotherapy to the patients with cervical cancer.

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