Diarylpyrrolone based fluorophore for the selective spectrofluorometric method for determination of Linagliptin antidiabetic drug in pharmaceutical tablets

2019 ◽  
Vol 148 ◽  
pp. 555-560 ◽  
Author(s):  
Mahmoud A. Omar ◽  
Ahmed M. Haredy ◽  
Gamal A. Saleh ◽  
A.H. Naggar ◽  
Sayed M. Derayea
Keyword(s):  
Antidiabetic Drug ◽  
Pharmaceutical Tablets ◽  
Spectrofluorometric Method

A Simple Spectrofluorometric Method for the Determination of Total Auxins in Mung Bean Sprouts

2020 ◽  
Vol 75 (11) ◽  
pp. 1404-1407
Author(s):  
Aziguli Yigaimu ◽  
Jiahua Chang ◽  
Amina Hoji ◽  
Turghun Muhammad ◽  
Burabiye Yakup ◽  
...  
Keyword(s):  
Mung Bean ◽  
Mung Bean Sprouts ◽  
Spectrofluorometric Method ◽  
Bean Sprouts

scholarly journals Determination of drug, excipients and coating distribution in pharmaceutical tablets using NIR-CI

2012 ◽  
Vol 2 (2) ◽  
pp. 90-97 ◽  
Author(s):  
Anna Palou ◽  
Jordi Cruz ◽  
Marcelo Blanco ◽  
Jaume Tomàs ◽  
Joaquín de los Ríos ◽  
...  
Keyword(s):  
Pharmaceutical Tablets

Simultaneous Determination of Ibuprofen and Pseudoephedrine Hydrochloride in Pharmaceutical Tablets by Reversed-Phase HPLC

2009 ◽  
Vol 42 (18) ◽  
pp. 2951-2961 ◽  
Author(s):  
Marie-Hélène Langlois ◽  
Philippe Dallet ◽  
Tina Kauss ◽  
Jean-Pierre Dubost
Keyword(s):  
Simultaneous Determination ◽  
Reversed Phase ◽  
Reversed Phase Hplc ◽  
Pharmaceutical Tablets

Cathodic Stripping Voltammetric Determination of Doxazosin in Urine and Pharmaceutical Tablets Using Carbon Paste Electrodes

The Analyst ◽  
1997 ◽  
Vol 122 (8) ◽  
pp. 849-854 ◽  
Author(s):  
Adela Arranz ◽  
Susana Fernández de Betoño ◽  
José M. Moreda ◽  
Adolfo Cid ◽  
Juan F. Arranz
Keyword(s):  
Voltammetric Determination ◽  
Carbon Paste ◽  
Pharmaceutical Tablets ◽  
Carbon Paste Electrodes ◽  
Cathodic Stripping

scholarly journals Simple Spectrophotometric Method for Determination of Paroxetine in Tablets Using 1,2-Naphthoquinone-4-Sulphonate as a Chromogenic Reagent

2009 ◽  
Vol 2009 ◽  
pp. 1-8 ◽  
Author(s):  
Ibrahim A. Darwish ◽  
Heba H. Abdine ◽  
Sawsan M. Amer ◽  
Lama I. Al-Rayes
Keyword(s):  
Spectrophotometric Method ◽  
Correlation Coefficients ◽  
Molar Absorptivity ◽  
Official Method ◽  
Calibration Data ◽  
Pharmaceutical Tablets ◽  
Relative Standard ◽  
Label Claim ◽  
Colored Product

Simple and rapid spectrophotometric method has been developed and validated for the determination of paroxetine (PRX) in tablets. The proposed method was based on nucleophilic substitution reaction of PRX with 1,2-naphthoquinone-4-sulphonate (NQS) in an alkaline medium to form an orange-colored product of maximum absorption peak () at 488 nm. The stoichiometry and kinetics of the reaction were studied, and the reaction mechanism was postulated. Under the optimized reaction conditions, Beer's law correlating the absorbance (A) with PRX concentration (C) was obeyed in the range of 1–8 g . The regression equation for the calibration data was: A = 0.0031 + 0.1609 C, with good correlation coefficients (0.9992). The molar absorptivity () was L  1 . The limits of detection and quantitation were 0.3 and 0.8 g , respectively. The precision of the method was satisfactory; the values of relative standard deviations did not exceed 2%. The proposed method was successfully applied to the determination of PRX in its pharmaceutical tablets with good accuracy and precisions; the label claim percentage was %. The results obtained by the proposed method were comparable with those obtained by the official method.

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