Aligning an integrative health initiative or program with the organization’s mission, vision, and values is critical. Implementation of integrative therapies is an effective strategy to achieve organizational goals. Understanding the needs of stakeholders and end users is a critical first step. This chapter discusses building an integrative health program in the context of organizational and system change. The emphasis is on the Triple Aim initiative, which focuses on the simultaneous pursuit of three aims: improving the health of the population, enhancing the patient experience of care (including quality, access, and reliability), and reducing the per capita cost of care. Design, implementation, and evaluation are covered.