Comparative evaluation of meglumine antimoniate encapsulated in a mixture of conventional and PEGylated liposomes and immunotherapy using an anti-canine IL-10 receptor-blocking monoclonal antibody on canine visceral leishmaniasis

2022 ◽  
Vol 141 ◽  
pp. 70-78
Author(s):  
Jamille Mirelle de Oliveira Cardoso ◽  
Rory Cristiane Fortes de Brito ◽  
Fernando Augusto Siqueira Mathias ◽  
Levi Eduardo Soares Reis ◽  
João Filipe Pereira Vieira ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Visceral Leishmaniasis ◽  
Comparative Evaluation ◽  
Canine Visceral Leishmaniasis ◽  
Receptor Blocking ◽  
Meglumine Antimoniate ◽  
Pegylated Liposomes

Comparative evaluation of enzyme-linked immunosorbent assay based on crude and purified antigen in the diagnosis of canine visceral leishmaniasis in symptomatic and oligosymptomatic dogs

2008 ◽  
Vol 157 (3-4) ◽  
pp. 175-181 ◽  
Author(s):  
Teresinha Cristina Cândido ◽  
Sílvia Helena Venturoli Perri ◽  
Tatiana de Oliveira Gerzoschkwitz ◽  
Maria Cecília Rui Luvizotto ◽  
Valéria Marçal Felix de Lima
Keyword(s):  
Visceral Leishmaniasis ◽  
Immunosorbent Assay ◽  
Comparative Evaluation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Canine Visceral Leishmaniasis ◽  
Purified Antigen

scholarly journals Evaluation of an immunochemotherapeutic protocol constituted of N-methyl meglumine antimoniate (Glucantime®) and the recombinant Leish-110f®+MPL-SE® vaccine to treat canine visceral leishmaniasis

Vaccine ◽  
2008 ◽  
Vol 26 (12) ◽  
pp. 1585-1594 ◽  
Author(s):  
Jorge Miret ◽  
Evaldo Nascimento ◽  
Weverton Sampaio ◽  
João Carlos França ◽  
Ricardo Toshio Fujiwara ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Canine Visceral Leishmaniasis ◽  
Meglumine Antimoniate

scholarly journals Treatment of canine visceral leishmaniasis with Milteforan™ induces Leishmania infantum resistance to miltefosine and amphotericin B

2021 ◽  
Author(s):  
Gustavo Gonçalves ◽  
Monique Paiva Campos ◽  
Alessandra Silva Gonçalves ◽  
Lia Carolina Soares Medeiros ◽  
Fabiano Borges Figueiredo
Keyword(s):  
Visceral Leishmaniasis ◽  
Amphotericin B ◽  
Leishmania Infantum ◽  
Cross Resistance ◽  
Canine Visceral Leishmaniasis ◽  
In Vitro Susceptibility ◽  
Meglumine Antimoniate ◽  
Parasite Fitness ◽  
The Impact

Visceral leishmaniasis (VL) is the most severe form of leishmaniasis and is caused by Leishmania infantum in the Americas. Since the use of Milteforam™ was authorized to treat canine visceral leishmaniasis (CVL) in Brazil in 2017, there has also been fear of the emergence of parasites resistant to this drug and, through cross-resistance mechanisms, to meglumine antimoniate and amphotericin B. Additionally, the literature shows that acquisition of resistance is followed by increased parasite fitness, with higher rates of proliferation, infectivity and metacyclogenesis, which are determining factors for parasite virulence. In this context, this study aims to analyze the impact of treating a dog with Milteforan™ on the generation of parasites resistant to miltefosine, meglumine antimoniate, and amphotericin B. To this end, in vitro susceptibility tests were conducted against these drugs with T0 (parasites isolated from the dog before treatment with Milteforan™), T1 (after one course of treatment), and T2 (after two courses of treatment) isolates. The rates of cell proliferation, infectivity, and metacyclogenesis of the isolates were also evaluated. The results indicate a gradual increase in parasite resistance to miltefosine and amphotericin B with increasing the number of treatment courses. A trend increase in the metacyclogenesis rate of the parasites was also observed as drug resistance increased. Therefore, treatment of CVL with Milteforan™ induces resistance to miltefosine and amphotericin B as well as changes in parasite fitness, and may have an impact on animal and human public health.

Canine visceral leishmaniasis: Comparison of in vitro leishmanicidal activity of marbofloxacin, meglumine antimoniate and sodium stibogluconate

2006 ◽  
Vol 135 (2) ◽  
pp. 137-146 ◽  
Author(s):  
Ioannis Vouldoukis ◽  
Sandrine Rougier ◽  
Bernard Dugas ◽  
Paco Pino ◽  
Dominique Mazier ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Canine Visceral Leishmaniasis ◽  
Sodium Stibogluconate ◽  
Leishmanicidal Activity ◽  
Meglumine Antimoniate

scholarly journals Experimental Evaluation of Second-Line Oral Treatments of Visceral Leishmaniasis Caused by Leishmania infantum

1999 ◽  
Vol 43 (1) ◽  
pp. 172-174 ◽  
Author(s):  
Jean-Pierre Gangneux ◽  
Michael Dullin ◽  
Annie Sulahian ◽  
Yves Jean-Francois Garin ◽  
Francis Derouin
Keyword(s):  
Visceral Leishmaniasis ◽  
Murine Model ◽  
Experimental Evaluation ◽  
Leishmania Infantum ◽  
Parasite Load ◽  
Second Line ◽  
Meglumine Antimoniate ◽  
Marked Activity

ABSTRACT In a murine model of Leishmania infantum visceral leishmaniasis, metronidazole, ketoconazole, fluconazole, itraconazole, and terbinafine were less effective than antimonial agents in reducing hepatic parasite load. Ketoconazole potentiated the effect of meglumine antimoniate reference therapy through its marked activity against spleen infection.

Diagnostic and prognostic potential of antibodies against O-acetylated sialic acids in canine visceral leishmaniasis

1999 ◽  
Vol 70 (1-2) ◽  
pp. 55-65 ◽  
Author(s):  
Mitali Chatterjee ◽  
Gad Baneth ◽  
Charles L Jaffe ◽  
Vineeta Sharma ◽  
Chitra Mandal
Keyword(s):  
Visceral Leishmaniasis ◽  
Sialic Acids ◽  
Canine Visceral Leishmaniasis

scholarly journals Evaluation of a new set of recombinant antigens for the serological diagnosis of human and canine visceral leishmaniasis

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184867 ◽  
Author(s):  
Franklin B. Magalhães ◽  
Artur L. Castro Neto ◽  
Marilia B. Nascimento ◽  
Wagner J. T. Santos ◽  
Zulma M. Medeiros ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Serological Diagnosis ◽  
Canine Visceral Leishmaniasis ◽  
Recombinant Antigens

scholarly journals Effectiveness of Short-Course Meglumine Antimoniate (Glucantime ® ) for Treatment of Visceral Leishmaniasis: A 13-Year, Multistage, Non-Inferiority Study in Iran

2016 ◽  
Vol 96 (1) ◽  
pp. 182-189 ◽  
Author(s):  
Abdolvahab Alborzi ◽  
Gholamreza Pouladfar ◽  
Armin Attar ◽  
Fatemeh Falahi ◽  
Zahra Jafarpour ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Meglumine Antimoniate ◽  
Short Course

scholarly journals Comparison between ELISA using total antigen and immunochromatography with antigen rK39 in the diagnosis of canine visceral leishmaniasis

2010 ◽  
Vol 173 (3-4) ◽  
pp. 330-333 ◽  
Author(s):  
Valéria Marçal Félix de Lima ◽  
Karina Reinaldo Fattori ◽  
Aparecida de Fátima Michelin ◽  
Luiz da Silveira Neto ◽  
Rosemere de O. Vasconcelos
Keyword(s):  
Visceral Leishmaniasis ◽  
Canine Visceral Leishmaniasis
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