Solution Thermodynamics of Ceftiofur Hydrochloride in Pure and Binary Solvents

2021 ◽  
pp. 116782
Author(s):  
Yuan Gao ◽  
Jingkang Wang ◽  
Hongxun Hao ◽  
Yan Xiao ◽  
Xin Huang ◽  
...  
Keyword(s):  
Solution Thermodynamics ◽  
Binary Solvents ◽  
Ceftiofur Hydrochloride

Solubility and Solution Thermodynamics of Flufenamic Acid Polymorphs in Two Binary Solvents

2019 ◽  
Vol 64 (10) ◽  
pp. 4214-4222
Author(s):  
Na Tang ◽  
Xinxu Zhang ◽  
Wei Du ◽  
Lei Zhang ◽  
Penggao Cheng ◽  
...  
Keyword(s):  
Solution Thermodynamics ◽  
Binary Solvents ◽  
Flufenamic Acid

Determination and correlation of solubility and solution thermodynamics of oxiracetam in three (alcohol + water) binary solvents

2016 ◽  
Vol 96 ◽  
pp. 12-23 ◽  
Author(s):  
Kangli Li ◽  
Shichao Du ◽  
Songgu Wu ◽  
Dongchen Cai ◽  
Jinxu Wang ◽  
...  
Keyword(s):  
Solution Thermodynamics ◽  
Binary Solvents ◽  
Alcohol Water

A description of effect of composition of mixed binary solvents on processes in solutions

1988 ◽  
Vol 53 (4) ◽  
pp. 671-685 ◽  
Author(s):  
Oldřich Pytela ◽  
Miroslav Ludwig
Keyword(s):  
Gibbs Energy ◽  
Mixed Solvents ◽  
Theoretical Description ◽  
Energy Change ◽  
Binary Solvents ◽  
Gibbs Energy Change ◽  
Order Model ◽  
Significant Difference

A theoretical description of the effect of changed composition of mixed solvents on processes in solutions has been suggested on the basis of the proportionality between the Gibbs energy change of the process and that of the solvent due to the transition from pure components to the mixture. The additional Gibbs energy has been expressed by means of the so-called classical functions by Margules, van Laar-Wohl, and van Laar-Null. The application to 115 various processes (pK, IR, UV-VIS, NMR, log k, and others) has confirmed that the theoretical presumptions are justified, the most suitable being Margules' 4th order model which shows a statistically significant difference from the models of lower orders.

Study on the solid-liquid equilibrium of l-malic acid in binary solvents

2021 ◽  
Vol 325 ◽  
pp. 115113
Author(s):  
Zhicheng Gao ◽  
Ying Li ◽  
Xunqiu Wang
Keyword(s):  
Malic Acid ◽  
Binary Solvents ◽  
Liquid Equilibrium ◽  
Solid Liquid

scholarly journals Impact of Ceftiofur Administration in Steers on the Prevalence and Antimicrobial Resistance of Campylobacter spp.

2021 ◽  
Vol 9 (2) ◽  
pp. 318
Author(s):  
Sicun Fan ◽  
Derek Foster ◽  
William G. Miller ◽  
Jason Osborne ◽  
Sophia Kathariou
Keyword(s):  
Antimicrobial Resistance ◽  
Bacterial Resistance ◽  
Active Drug ◽  
Free Acid ◽  
Structural Similarity ◽  
Drug Concentrations ◽  
Pre Treatment ◽  
Ceftiofur Hydrochloride ◽  
Campylobacter Spp

Bacterial resistance to ceftiofur raises health concerns due to ceftiofur’s extensive veterinary usage and structural similarity with the human antibiotic ceftriaxone. Ceftiofur crystalline-free acid (CCFA) and ceftiofur hydrochloride (CHCL) are ceftiofur types used therapeutically in cattle, but their potential impacts on Campylobacter prevalence and antimicrobial resistance remain unclear. In this study two groups of steers were each treated with CCFA or CHCL. In vivo active drug concentrations were measured and fecal samples were analyzed for Campylobacter for up to 42 days post-treatment. Following administration, the colonic concentration of ceftiofur initially increased then dropped to pre-treatment levels by day 8. The estimated prevalence of Campylobacter spp. was significantly (p = 0.0009) higher during the first week after CCFA treatment than after CHCL treatment (81.3% vs. 45.2%). Campylobacter jejuni predominated overall, with other Campylobacter spp. mainly identified in the first week after CCFA treatment. No treatment impacts were noted on ceftiofur minimum inhibitory concentration (MIC) for C. jejuni (10–20 μg/mL). More C. jejuni genotypes were detected in CCFA-treated than CHCL-treated steers. These findings suggest that ceftiofur did not significantly impact Campylobacter prevalence or ceftiofur MIC. However, CHCL may be preferable due to the lower likelihood of temporary increases in Campylobacter prevalence.

Solubility and thermodynamic analysis of musk ketone in four binary solvents from T= (273.15 to 313.15) K

2021 ◽  
Vol 329 ◽  
pp. 115415
Author(s):  
Yuwei Hua ◽  
Genlei Wei ◽  
Shishuai Shi ◽  
Chunmei Cao ◽  
Xuening Zhang ◽  
...  
Keyword(s):  
Thermodynamic Analysis ◽  
Binary Solvents
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