scholarly journals Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

2012 ◽  
Vol 6 (5) ◽  
pp. 484-493 ◽  
Author(s):  
Sangkil Nam ◽  
Jun Xie ◽  
Angela Perkins ◽  
Yuelong Ma ◽  
Fan Yang ◽  
...  
Keyword(s):  
Natural Product ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Stat3 Signaling ◽  
Human Melanoma Cells ◽  
Synthetic Derivatives ◽  
Derivatives Of

scholarly journals NF-YA promotes invasion and angiogenesis by upregulating EZH2-STAT3 signaling in human melanoma cells

2016 ◽  
Vol 35 (6) ◽  
pp. 3630-3638 ◽  
Author(s):  
ZIHAN XU ◽  
YAOWEN SUN ◽  
YADONG GUO ◽  
GAOPING QIN ◽  
SHENGZHI MU ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Stat3 Signaling ◽  
Human Melanoma Cells

scholarly journals Flavonoids Bearing an O-Arabinofuranosyl-(1→3)-Rhamnoside Moiety from Cladocolea Micrantha: Inhibitory Effect on Human Melanoma Cells

2012 ◽  
Vol 7 (10) ◽  
pp. 1934578X1200701
Author(s):  
Anderson C. Guimarães ◽  
Alvicler Magalhães ◽  
Marcos J. Nakamura ◽  
Antonio C. Siani ◽  
Christina Barja-Fidalgo ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Spectral Methods ◽  
Inhibitory Effect ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Derivatives Of ◽  
Transwell System

Eleven known triterpenes (α-amyrin, β-amyrin, lupeol, and their respective acetates, 3- O-acetyl derivatives of betulinic, oleanolic, and ursolic acids, cycloartenol, and tirucall-7,24-dienol), two new flavonols presenting an uncommon interglycosidic O-(1→3) linkage (kaempferol 3- O-α-L-arabinofuranosyl-(1→3)-α-L-rhamnoside and quercetin 3- O-α-L-arabinofuranosyl-(1→3)-α-L-rhamnoside), β-sitosterol, stigmasterol, quercetin, and gallic acid were isolated from the Amazonian medicinal mistletoe, Cladocolea micrantha Kuijt (Loranthaceae). Their structures were established by spectral methods and eventual chromatographic comparisons. The quercetin derivative was not cytotoxic to MV3 human melanoma cells, but was able, when administered at 1 μg/mL, to promote a twofold inhibition of the migration of the cells through the transwell system when compared with paclitaxel at 5 μM.

Abstract 764: 6-Bromoindirubin-3′-oxime induces apoptosis of human melanoma cells associated with inhibition of JAK/STAT3 signaling

2010 ◽  
Author(s):  
Xiangli Liu ◽  
Sangkil Nam ◽  
Yan Tian ◽  
Marina Kritsanida ◽  
Prokpios Magiatis ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Stat3 Signaling ◽  
Human Melanoma Cells

scholarly journals 6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells

2011 ◽  
Vol 71 (11) ◽  
pp. 3972-3979 ◽  
Author(s):  
Lucy Liu ◽  
Sangkil Nam ◽  
Yan Tian ◽  
Fan Yang ◽  
Jun Wu ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Stat3 Signaling ◽  
Human Melanoma Cells
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