Structure activity relationship analysis of antiproliferative cyclic C5-curcuminoids without DNA binding: Design, synthesis, lipophilicity and biological activity

Activity Relationship ◽

Design Synthesis ◽

Relationship Analysis ◽

Antileishmanial Chalcones: Statistical Design, Synthesis, and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

Journal of Medicinal Chemistry ◽

10.1021/jm980410m ◽

1998 ◽

Vol 41 (24) ◽

pp. 4819-4832 ◽

Cited By ~ 183

Author(s):

Simon Feldbæk Nielsen ◽

Søren Brøgger Christensen ◽

Gabriele Cruciani ◽

Arsalan Kharazmi ◽

Tommy Liljefors

Keyword(s):

Three Dimensional ◽

Statistical Design ◽

Quantitative Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Relationship Analysis ◽

Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113248 ◽

2021 ◽

Vol 214 ◽

pp. 113248

Author(s):

Mingfeng Yu ◽

Theodosia Teo ◽

Yuchao Yang ◽

Manjun Li ◽

Yi Long ◽

...

Keyword(s):

Biological Evaluation ◽

Activity Relationship ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity ◽

Orally Bioavailable

Cover Picture: Design, Synthesis, and Structure-Activity Relationship Analysis of Thiazolo[3,2-a ]pyrimidine Derivatives with Anti-inflammatory Activity in Acute Lung Injury (ChemMedChem 13/2017)

ChemMedChem ◽

10.1002/cmdc.201700367 ◽

2017 ◽

Vol 12 (13) ◽

pp. 1013-1013

Author(s):

Lingfeng Chen ◽

Yiyi Jin ◽

Weitao Fu ◽

Siyang Xiao ◽

Chen Feng ◽

...

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Inflammatory Activity ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity ◽

Anti Inflammatory

Design, synthesis, testing, and quantitative structure-activity relationship analysis of substituted salicylaldehyde Schiff bases of 1-amino-3-hydroxyguanidine tosylate as new antiviral agents against coronavirus

Journal of Medicinal Chemistry ◽

10.1021/jm00164a023 ◽

1990 ◽

Vol 33 (2) ◽

pp. 608-614 ◽

Cited By ~ 115

Author(s):

Pou Hsiung Wang ◽

James G. Keck ◽

Eric J. Lien ◽

Michael M. C. Lai

Keyword(s):

Schiff Bases ◽

Antiviral Agents ◽

Quantitative Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Relationship Analysis ◽

Discovery of Novel Selective Inhibitors of Human Intestinal Carboxylesterase for the Amelioration of Irinotecan-Induced Diarrhea: Synthesis, Quantitative Structure-Activity Relationship Analysis, and Biological Activity

Molecular Pharmacology ◽

10.1124/mol.65.6.1336 ◽

2004 ◽

Vol 65 (6) ◽

pp. 1336-1343 ◽

Cited By ~ 65

Author(s):

Randy M. Wadkins ◽

Janice L Hyatt ◽

Kyoung Jin P. Yoon ◽

Christopher L. Morton ◽

Richard E. Lee ◽

...

Keyword(s):

Biological Activity ◽

Quantitative Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Selective Inhibitors ◽

Relationship Analysis ◽

Biological activity, design, synthesis and structure activity relationship of some novel derivatives of curcumin containing sulfonamides

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.03.012 ◽

2013 ◽

Vol 64 ◽

pp. 579-588 ◽

Cited By ~ 33

Author(s):

Jaggi Lal ◽

Sushil K. Gupta ◽

D. Thavaselvam ◽

Dau D. Agarwal

Keyword(s):

Biological Activity ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Of ◽

Derivatives Of ◽

Activity Design

Design, Synthesis, and Structure-Activity Relationship Analysis of Thiazolo[3,2-a ]pyrimidine Derivatives with Anti-inflammatory Activity in Acute Lung Injury

ChemMedChem ◽

10.1002/cmdc.201700175 ◽

2017 ◽

Vol 12 (13) ◽

pp. 1022-1032 ◽

Cited By ~ 10

Author(s):

Lingfeng Chen ◽

Yiyi Jin ◽

Weitao Fu ◽

Siyang Xiao ◽

Chen Feng ◽

...

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Inflammatory Activity ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity ◽

Anti Inflammatory

Design, synthesis, biological activity and structure-activity relationship studies of chalcone derivatives as potential anti-Candida agents

The Journal of Antibiotics ◽

10.1038/s41429-018-0048-9 ◽

2018 ◽

Vol 71 (8) ◽

pp. 702-712 ◽

Cited By ~ 12

Author(s):

Jéssica T. Andrade ◽

Felipe R. S. Santos ◽

William G. Lima ◽

Carla D. F. Sousa ◽

Lohanna S. F. M. Oliveira ◽

...

Keyword(s):

Biological Activity ◽

Activity Relationship ◽

Design Synthesis ◽

Chalcone Derivatives ◽

Pyrazolo[3,4-d]pyrimidine-based dual EGFR T790M/HER2 inhibitors: Design, synthesis, structure–activity relationship and biological activity as potential antitumor and anticonvulsant agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113222 ◽

2021 ◽

Vol 214 ◽

pp. 113222

Author(s):

Phoebe F. Lamie ◽

Asmaa M. El-Kalaawy ◽

Noha S. Abdel Latif ◽

Laila A. Rashed ◽

John N. Philoppes

Keyword(s):

Biological Activity ◽

Activity Relationship ◽

Design Synthesis ◽

Anticonvulsant Agents ◽

Structure Activity ◽

Egfr T790m ◽

Potential Antitumor

Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.3109/14756366.2011.604851 ◽

2012 ◽

Vol 27 (5) ◽

pp. 628-640 ◽

Cited By ~ 3

Author(s):

Shenghui Yu ◽

Linna Zhang ◽

Shifeng Yan ◽

Peng Wang ◽

Tino Sanchez ◽

...

Keyword(s):

Biological Activity ◽

Activity Relationship ◽

Integrase Inhibitors ◽

Relationship Analysis ◽

Structure Activity ◽

Hiv 1