M. del Carmen Salazar-López
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J. Alberto Guevara-Salazar
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Mónica G. Arellano-Mendoza
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Hugo A. Jiménez-Vázquez
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Adriana Benavides
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...
:
Anticonvulsants are drugs used in the treatment of seizures, their pharmacology includes promoters
of brain inhibition and inhibitors of brain activity; Of the latter, voltage-dependent sodium channel blockers (VGSCB) are
the most widely used in therapeutics.
Objective:
To propose the structural requirements of VGSC blockers through a quantitative structure-activity relationship
analysis of drugs with proven activity.
Methods:
IC50 values of anticonvulsant drugs on VGSCs were considered under similar experimental conditions; some
physicochemical properties of the molecules that were correlated with their biological activity were determined in silico.
Results:
Relationships were found between the dipole moment, pKa, EHOMO, and MR with the biological activity, which infers that between greater polarity and basicity of the drugs, their activity as blockers will increase. Subsequently, the structural subclassification of the drugs was carried out, based on the urea derivation, the groups of which were: Group 1 (direct
and bioisoster derivatives) and Group 2 (homologue and vinylogue derivatives of urea).
Conclusion:
The biological activity depends on the polarity, basicity, and electronic density of the drugs. The derivation of
urea is essential, which is present in its original substituted form or a bioisosteric form. Urea can be in the form of a homologue or a vinylogue at the ends of the molecule. Aromatic substitution to the urea portion is necessary.
Structure activity relationship analysis of antiproliferative cyclic C5-curcuminoids without DNA binding: Design, synthesis, lipophilicity and biological activity