Applications and implications of whole-slide imaging in breast pathology

2021 ◽  
Author(s):  
Rebecca A. Millican-Slater ◽  
Emad A. Rakha
Keyword(s):  
Whole Slide Imaging ◽  
Breast Pathology

scholarly journals Digital Technology in Diagnostic Breast Pathology and Immunohistochemistry

Pathobiology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Emad A. Rakha ◽  
Konstantinos Vougas ◽  
Puay Hoon Tan
Keyword(s):  
Artificial Intelligence ◽  
Digital Technology ◽  
Voice Recognition ◽  
Digital Data ◽  
Recent Application ◽  
Whole Slide Imaging ◽  
Breast Pathology ◽  
Digital Data Processing ◽  
Computer Vision Technology ◽  
Recognition Systems

Digital technology has been used in the field of diagnostic breast pathology and immunohistochemistry (IHC) for decades. Examples include automated tissue processing and staining, digital data processing, storing and management, voice recognition systems, and digital technology-based production of antibodies and other IHC reagents. However, the recent application of whole slide imaging technology and artificial intelligence (AI)-based tools has attracted a lot of attention. The use of AI tools in breast pathology is discussed briefly as it is covered in other reviews. Here, we present the main application of digital technology in IHC. This includes automation of IHC staining, using image analysis systems and computer vision technology to interpret IHC staining, and the use of AI-based tools to predict marker expression from haematoxylin and eosin-stained digitalized images.

Diagnostic Problems in Breast Pathology: The Benefit of Ultrastructural and Immunocytochemical Analysis

1987 ◽  
Vol 11 (2) ◽  
pp. 293-311 ◽  
Author(s):  
Jahn Nesland ◽  
Ruth Holm ◽  
Sigurd Lunde ◽  
Jan Vincents Johannessen
Keyword(s):  
Breast Pathology ◽  
Immunocytochemical Analysis ◽  
Diagnostic Problems

Local Recurrence of Breast Cancer after MammoSite® Brachytherapy

2006 ◽  
Vol 72 (9) ◽  
pp. 798-801
Author(s):  
Matthew Voth ◽  
Raye Budway ◽  
Angela Keleher ◽  
Philip F. Caushaj
Keyword(s):  
Breast Cancer ◽  
Treatment Plan ◽  
Breast Conservation ◽  
Radical Mastectomy ◽  
Axillary Lymph ◽  
Ultrasound Guided ◽  
Breast Pathology ◽  
Poorly Differentiated ◽  
Her 2 ◽  
Negative Tumor

Women undergoing breast conservation therapy (BCT) for stage 1 breast cancer have adjuvant external beam radiotherapy (EBR). In addition, the use of brachytherapy radiation is being used. We present two local tumor recurrences for review. Our first patient underwent BCT, sentinel lymph node biopsy (SLNBx) and MammoSite® brachytherapy for a T1N0M0 infiltrating ductal carcinoma (IDC) of the right breast. Pathology: 0.6 cm poorly differentiated ER, PR, and Her-2/ Neu negative IDC. At 18 months, she had palpable axillary lymph nodes. Fine needle aspiration and ultrasound-guided core biopsy of a nodule showed IDC. She underwent modified radical mastectomy (MRM) and EBR. Our second patient underwent BCT, SLNBx, and MammoSite® brachytherapy for a T1N0M0 IDC of the left breast. Pathology: 0.8 cm poorly differentiated, ER+, PR-, and Her-2/Neu negative tumor. At 18 months, a retroareolar mass was detected. Ultrasound guided core needle biopsy showed recurrent IDC. She chose a re-excision and EBR and not MRM. Pathology: 1.3 cm poorly differentiated, ER+, PR-, and Her-2/Neu negative tumor. Our 2 recurrences were >2 cm away from the lumpectomy site and therefor outside the 1 cm treatment plan of the MammoSite® catheter. Both recurrences were biologically identical to the initial tumors and are felt to be local failures rather than new primaries.

scholarly journals Histological assessment of granulomas in natural and experimental Schistosoma mansoni infections using whole slide imaging

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184696 ◽  
Author(s):  
Kátia B. Amaral ◽  
Thiago P. Silva ◽  
Felipe F. Dias ◽  
Kássia K. Malta ◽  
Florence M. Rosa ◽  
...  
Keyword(s):  
Schistosoma Mansoni ◽  
Whole Slide Imaging ◽  
Histological Assessment

Computation of semantic similarity within an ontology of breast pathology to assist inter-observer consensus

2006 ◽  
Vol 36 (7-8) ◽  
pp. 768-788 ◽  
Author(s):  
Olivier Steichen ◽  
Christel Daniel - Le Bozec ◽  
Maxime Thieu ◽  
Eric Zapletal ◽  
Marie-Christine Jaulent
Keyword(s):  
Semantic Similarity ◽  
Breast Pathology
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