TCDD-induced homologous recombination: the role of the Ah receptor versus oxidative DNA damage

2004 ◽  
Vol 563 (1) ◽  
pp. 71-79 ◽  
Author(s):  
Clara Y.Y. Chan ◽  
Perry M. Kim ◽  
Louise M. Winn
Keyword(s):  
Dna Damage ◽  
Homologous Recombination ◽  
Oxidative Dna Damage ◽  
Ah Receptor

Role of oxidative DNA damage in the mechanism of fecapentaene 12 genotoxicity

1994 ◽  
Vol 15 (11) ◽  
pp. 2559-2566 ◽  
Author(s):  
T.M.C.M. de Kok ◽  
D.M.F.A. Pachen ◽  
J.M.S. van Maanen ◽  
M.V.M. Lafleur ◽  
E.J. Westmijze ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage

scholarly journals Potential role of oxidative DNA damage in the impact of PNPLA3 variant (rs 738409 C>G) in hepatocellular carcinoma risk

Hepatology ◽  
2014 ◽  
Vol 60 (3) ◽  
pp. 1110-1111 ◽  
Author(s):  
Emeric Limagne ◽  
Vanessa Cottet ◽  
Alexia Karen Cotte ◽  
Samia Hamza ◽  
Patrick Hillon ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Potential Role ◽  
The Impact ◽  
Carcinoma Risk

scholarly journals The role of metal ion binding in the antioxidant mechanisms of reduced and oxidized glutathione in metal-mediated oxidative DNA damage

Metallomics ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 79-91 ◽  
Author(s):  
Elias O. U. Eteshola ◽  
Devin A. Haupt ◽  
Stephen I. Koos ◽  
Lee A. Siemer ◽  
Daniel L. Morris
Keyword(s):  
Dna Damage ◽  
Metal Ion ◽  
Oxidative Dna Damage ◽  
Ion Binding ◽  
Oxidized Glutathione ◽  
Metal Ion Binding ◽  
Reduced And Oxidized Glutathione ◽  
Antioxidant Mechanisms

GSH and GSSG appear to function as antioxidants against metal-mediated oxidative DNA damage by coordinating Fe(ii) and Cu(ii).

scholarly journals Regulation and pharmacological targeting of RAD51 in cancer

NAR Cancer ◽  
2020 ◽  
Vol 2 (3) ◽  
Author(s):  
McKenzie K Grundy ◽  
Ronald J Buckanovich ◽  
Kara A Bernstein
Keyword(s):  
Ovarian Cancer ◽  
Dna Damage ◽  
Homologous Recombination ◽  
Patient Outcomes ◽  
Cancer Biology ◽  
Cancer Resistance ◽  
Breast And Ovarian Cancer ◽  
Resistance To Therapy ◽  
Damage Repair

Abstract Regulation of homologous recombination (HR) is central for cancer prevention. However, too little HR can increase cancer incidence, whereas too much HR can drive cancer resistance to therapy. Importantly, therapeutics targeting HR deficiency have demonstrated a profound efficacy in the clinic improving patient outcomes, particularly for breast and ovarian cancer. RAD51 is central to DNA damage repair in the HR pathway. As such, understanding the function and regulation of RAD51 is essential for cancer biology. This review will focus on the role of RAD51 in cancer and beyond and how modulation of its function can be exploited as a cancer therapeutic.

scholarly journals The role of CSA in the response to oxidative DNA damage in human cells

Oncogene ◽  
2007 ◽  
Vol 26 (30) ◽  
pp. 4336-4343 ◽  
Author(s):  
M D'Errico ◽  
E Parlanti ◽  
M Teson ◽  
P Degan ◽  
T Lemma ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Human Cells

The role of catechols and free radicals in benzene toxicity: An oxidative DNA damage pathway

2009 ◽  
Vol 50 (9) ◽  
pp. 771-780 ◽  
Author(s):  
George Barreto ◽  
Diego Madureira ◽  
Francisco Capani ◽  
Laura Aon-Bertolino ◽  
Ezequiel Saraceno ◽  
...  
Keyword(s):  
Dna Damage ◽  
Free Radicals ◽  
Oxidative Dna Damage

Therapeutic role of curcumin in oxidative DNA damage caused by formaldehyde

2015 ◽  
Vol 78 (5) ◽  
pp. 391-395 ◽  
Author(s):  
Gulay Ciftci ◽  
Abdurrahman Aksoy ◽  
Sena cenesiz ◽  
Mehtap unlu sogut ◽  
Gul Fatma Yarim ◽  
...  
Keyword(s):  
Dna Damage ◽  
Oxidative Dna Damage ◽  
Therapeutic Role
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