Potential role of oxidative DNA damage in the impact of PNPLA3 variant (rs 738409 C>G) in hepatocellular carcinoma risk

It has long been acknowledged that changes in the regulation of gene expression may account for major organismal differences. However, we still do not fully understand how changes in gene expression evolve and how do such changes influence organisms’ differences. We are even less aware of the impact such changes might have in restricting gene flow between species. Here, we focus on studies of gene expression and speciation in the Drosophila model. We review studies that have identified gene interactions in post-mating reproductive isolation and speciation, particularly those that modulate male gene expression. We also address studies that have experimentally manipulated changes in gene expression to test their effect in post-mating reproductive isolation. We highlight the need for a more in-depth analysis of the role of selection causing disrupted gene expression of such candidate genes in sterile/inviable hybrids. Moreover, we discuss the relevance to incorporate more routinely assays that simultaneously evaluate the potential effects of environmental factors and genetic background in modulating plastic responses in male genes and their potential role in speciation.

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Metabolomics Reveals Aging-associated Attenuation of Noninvasive Radiation Biomarkers in Mice: Potential Role of Polyamine Catabolism and Incoherent DNA Damage-repair

Journal of Proteome Research ◽

10.1021/pr400161k ◽

2013 ◽

Vol 12 (5) ◽

pp. 2269-2281 ◽

Cited By ~ 23

Author(s):

Soumen K. Manna ◽

Kristopher W. Krausz ◽

Jessica A. Bonzo ◽

Jeffrey R. Idle ◽

Frank J. Gonzalez

Keyword(s):

Dna Damage ◽

Potential Role ◽

Dna Damage Repair ◽

Polyamine Catabolism ◽

Damage Repair

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Role of oxidative DNA damage in the mechanism of fecapentaene 12 genotoxicity

Carcinogenesis ◽

10.1093/carcin/15.11.2559 ◽

1994 ◽

Vol 15 (11) ◽

pp. 2559-2566 ◽

Cited By ~ 4

Author(s):

T.M.C.M. de Kok ◽

D.M.F.A. Pachen ◽

J.M.S. van Maanen ◽

M.V.M. Lafleur ◽

E.J. Westmijze ◽

...

Keyword(s):

Dna Damage ◽

Oxidative Dna Damage

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Inhibitory Effect of MicroRNA-376b-Overexpressing Bone Marrow Mesenchymal Stem Cells (BMSCs) on Malignant Characteristics of Glioma Cells Through Targeting Forkhead Box Protein P2 (FOXP2)

Journal of Biomaterials and Tissue Engineering ◽

10.1166/jbt.2022.2999 ◽

2022 ◽

Vol 12 (5) ◽

pp. 971-977

Author(s):

Ruoyu Zhu ◽

Zhonglin Wang

Keyword(s):

Glioma Cell ◽

Potential Role ◽

Glioma Cells ◽

Inhibitory Effect ◽

Transwell Assay ◽

Cell Behaviors ◽

Forkhead Box ◽

Marrow Mesenchymal Stem Cells ◽

The Impact

This study investigated the impact of microRNA (miR)-376b derived from BMSCs on glioma progression. BMSCs were transfected with miR-376b mimic, miR-376b inhibitor or NC and then cocultured with glioma cells followed by measuring cell behaviors by MTT assay, Transwell assay and flow cytometry, FOXP2 and miR-376b expression by Western blot and RT-qPCR. After confirming the inhibitory and mimicking activity of transfection, we found that overexpression of miR-376b in BMSCs decreased glioma cell invasion, migration and proliferation but promoted cell apoptosis within 24 h and 48 h after transfection along with reduced number of cells in S-phase. Mechanically, miR-376b targeted miR-376b and up-regulation of miR-376b caused down-regulation of FOXP2 (p < 0.05). Overexpression of miR-376b in BMSCs decelerated glioma cell cycle and inhibitedmalignant behaviors of glioma cells by targeting FOXP2 expression. These evidence unveils the potential role of FOXP2 as a biomarker for the treatment of gliomas.

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ATM-dependent pathways of chromatin remodelling and oxidative DNA damage responses

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.2016.0283 ◽

2017 ◽

Vol 372 (1731) ◽

pp. 20160283 ◽

Cited By ~ 25

Author(s):

N. Daniel Berger ◽

Fintan K. T. Stanley ◽

Shaun Moore ◽

Aaron A. Goodarzi

Keyword(s):

Dna Damage ◽

Oxidative Dna Damage ◽

Strand Break ◽

Chromatin Remodelling ◽

Double Strand Breaks ◽

Biochemical Network ◽

Regulatory Function ◽

Dna Double Strand Breaks ◽

Strand Breaks ◽

The Impact

Ataxia-telangiectasia mutated (ATM) is a serine/threonine protein kinase with a master regulatory function in the DNA damage response. In this role, ATM commands a complex biochemical network that signals the presence of oxidative DNA damage, including the dangerous DNA double-strand break, and facilitates subsequent repair. Here, we review the current state of knowledge regarding ATM-dependent chromatin remodelling and epigenomic alterations that are required to maintain genomic integrity in the presence of DNA double-strand breaks and/or oxidative stress. We will focus particularly on the roles of ATM in adjusting nucleosome spacing at sites of unresolved DNA double-strand breaks within complex chromatin environments, and the impact of ATM on preserving the health of cells within the mammalian central nervous system. This article is part of the themed issue ‘Chromatin modifiers and remodellers in DNA repair and signalling’.

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The potential role of relatives in designing person-centred assistive technologies (innovative practice)

Dementia ◽

10.1177/1471301216688395 ◽

2017 ◽

Vol 18 (7-8) ◽

pp. 3161-3164 ◽

Cited By ~ 1

Author(s):

Rudi Coetzer

Keyword(s):

Collaborative Design ◽

Potential Role ◽

Assistive Technologies ◽

Visual Spatial ◽

Innovative Practice ◽

The Impact

The paper explores the important role of relatives in designing assistive technologies in collaboration with practitioners. A brief case study reports the collaborative design of a 24-hour clock to reduce the impact of visual–spatial impairment on a family member's ability to read time and prevent temporal disorientation.

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Silver Nanoparticles as Potential Antiviral Agents

Pharmaceutics ◽

10.3390/pharmaceutics13122034 ◽

2021 ◽

Vol 13 (12) ◽

pp. 2034

Author(s):

Zubair Ahmed Ratan ◽

Fazla Rabbi Mashrur ◽

Anisha Parsub Chhoan ◽

Sadi Md. Shahriar ◽

Mohammad Faisal Haidere ◽

...

Keyword(s):

Silver Nanoparticles ◽

Potential Role ◽

Viral Infections ◽

Antiviral Agents ◽

Host Cells ◽

Characterization Methods ◽

New Horizons ◽

Bacteria And Fungi ◽

The Impact

Since the early 1990s, nanotechnology has led to new horizons in nanomedicine, which encompasses all spheres of science including chemistry, material science, biology, and biotechnology. Emerging viral infections are creating severe hazards to public health worldwide, recently, COVID-19 has caused mass human casualties with significant economic impacts. Interestingly, silver nanoparticles (AgNPs) exhibited the potential to destroy viruses, bacteria, and fungi using various methods. However, developing safe and effective antiviral drugs is challenging, as viruses use host cells for replication. Designing drugs that do not harm host cells while targeting viruses is complicated. In recent years, the impact of AgNPs on viruses has been evaluated. Here, we discuss the potential role of silver nanoparticles as antiviral agents. In this review, we focus on the properties of AgNPs such as their characterization methods, antiviral activity, mechanisms, applications, and toxicity.

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Evolving Role of Genomics in Genitourinary Neoplasms

Acta Medica Academica ◽

10.5644/ama2006-124.243 ◽

2019 ◽

Vol 48 (1) ◽

pp. 68

Author(s):

Michael E. Devitt ◽

Robert Dreicer

Keyword(s):

Dna Damage ◽

Genomic Data ◽

Treatment Decisions ◽

Response To Therapy ◽

Genomic Alterations ◽

Dna Damage And Repair ◽

Genitourinary Cancer ◽

Genitourinary Cancers ◽

The Impact

The aim of this article is to review the current role of genomic testing in the risk, prognosis, and treatment of genitourinary malignancies. The authors selected guidelines, publications, and abstracts relevant to the current and emerging role of genomics in genitourinary cancers. The risk of developing genitourinary cancer can be stratified based on genomic data. Prostate cancer has the strongest degree of heritability, with BRCA1/2 and HOXB13 mutations playing a role in familial disease. Genomic data is on the verge of informing treatment decisions across genitourinary cancers. mCRPC has diverse genomic alterations that represent potential therapeutic targets, including alterations in the AR pathway, DNA damage and repair pathways, cell cycle pathways, PI3K pathway, and Wnt signaling. Genomic alterations in clear cell renal cell carcinoma can inform prognosis and mutations in mTOR pathways predict response to mTOR inhibitors. Urothelial carcinoma can be classified into different subtypes based on gene expression profiling, which provides prognostic information and predicts response to chemotherapy and immunotherapy. Specific mutations have been identified that predict response to therapy including ERCC2 mutations and cisplatin, DNA damage and repair mutations and checkpoint inhibitors, and FGFR3 mutations and FGFR tyrosine kinase inhibitors such as erdafitinib.Conclusion. Genitourinary malignancies have not felt the impact of genomic data as greatly as other cancer types. The majority of benefit lies in identifying patients at high risk of genitourinary cancer. Fortunately, breakthroughs are on the horizon that will result in a greater incorporation of genomic information into treatment decisions for patients with genitourinary cancer.

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Marketing to the “middle of the pyramid” in emerging markets using a social network perspective

International Journal of Emerging Markets ◽

10.1108/ijoem-05-2013-0090 ◽

2014 ◽

Vol 9 (3) ◽

pp. 400-423 ◽

Cited By ~ 8

Author(s):

Tendai Chikweche ◽

Richard Fletcher

Keyword(s):

Social Networks ◽

Middle Class ◽

Potential Role ◽

Content Type ◽

Business Executives ◽

Advanced Economies ◽

Sub Saharan ◽

Corporate Social ◽

The Impact

Purpose – The purpose of this paper is to expand knowledge about how middle class consumers in Sub-Saharan African markets behave, focusing on the potential role of social networks and the subsequent interactions that take place between these consumers and firms. Design/methodology/approach – A qualitative research method approach comprising personal interviews and observations targeted at consumers and business executives was used covering all four countries. Findings – Key findings include identification of middle of the pyramid (MOP) social networks, their impact on consumer behaviour and nature of consumer and firm interactions that take place as a result of the impact of social networks. Research limitations/implications – The sample size was restricted to 80 consumers in each of the four countries. This might limit generalisability. Practical implications – The study provides managers with insights on the potential role of social networks on marketing to the MOP in Africa. Social implications – The study provides managers with insights on the potential opportunities for corporate social responsibility solutions at the MOP. Originality/value – Research into the middle class in markets other than western advanced economies is a relatively new area of study. The majority of studies on the middle class have focused on North America and Europe ignoring the merging middle class in Africa. Hence, this research expands knowledge by providing basis for exploring new insights on the emerging marketing opportunity within the middle class in Africa.

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