Study of oxidative DNA damage in TK6 human lymphoblastoid cells by use of the thymidine kinase gene-mutation assay and the in vitro modified comet assay: Determination of No-Observed-Genotoxic-Effect-Levels

Mutation Research/Genetic Toxicology and Environmental Mutagenesis ◽

10.1016/j.mrgentox.2011.09.003 ◽

2011 ◽

Vol 726 (2) ◽

pp. 151-159 ◽

Author(s):

Anne Platel ◽

Fabrice Nesslany ◽

Véronique Gervais ◽

Nancy Claude ◽

Daniel Marzin

Keyword(s):

Comet Assay ◽

Thymidine Kinase ◽

Oxidative Dna Damage ◽

Thymidine Kinase Gene ◽

Kinase Gene ◽

Mutation Assay ◽

Gene Mutation Assay

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Mouse Lymphoma Thymidine Kinase Gene Mutation Assay: International Workshop on Genotoxicity Tests Workgroup Report—Plymouth, UK 2002

Mutation Research/Genetic Toxicology and Environmental Mutagenesis ◽

10.1016/j.mrgentox.2003.07.003 ◽

2003 ◽

Vol 540 (2) ◽

pp. 127-140 ◽

Author(s):

Martha M Moore ◽

Masamitsu Honma ◽

Julie Clements ◽

George Bolcsfoldi ◽

Maria Cifone ◽

...

Keyword(s):

Thymidine Kinase ◽

Gene Mutation ◽

International Workshop ◽

Thymidine Kinase Gene ◽

Kinase Gene ◽

Mutation Assay ◽

Gene Mutation Assay ◽

Genotoxicity Tests ◽

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Mouse lymphoma thymidine kinase gene mutation assay: Follow-up meeting of the international workshop on Genotoxicity testing—Aberdeen, Scotland, 2003—Assay acceptance criteria, positive controls, and data evaluation

Environmental and Molecular Mutagenesis ◽

10.1002/em.20159 ◽

2006 ◽

Vol 47 (1) ◽

pp. 1-5 ◽

Author(s):

Martha M. Moore ◽

Masamitsu Honma ◽

Julie Clements ◽

George Bolcsfoldi ◽

Brian Burlinson ◽

...

Keyword(s):

Thymidine Kinase ◽

International Workshop ◽

Thymidine Kinase Gene ◽

Kinase Gene ◽

Mutation Assay ◽

Gene Mutation Assay ◽

Genotoxicity Testing ◽

Mouse Lymphoma ◽

Positive Controls

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Mouse lymphoma thymidine kinase gene mutation assay: Meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment

Mutation Research/Genetic Toxicology and Environmental Mutagenesis ◽

10.1016/j.mrgentox.2006.08.013 ◽

2007 ◽

Vol 627 (1) ◽

pp. 36-40 ◽

Author(s):

Martha M. Moore ◽

Masamitsu Honma ◽

Julie Clements ◽

George Bolcsfoldi ◽

Brian Burlinson ◽

...

Keyword(s):

Thymidine Kinase ◽

Gene Mutation ◽

San Francisco ◽

International Workshop ◽

Thymidine Kinase Gene ◽

Kinase Gene ◽

Mutation Assay ◽

Gene Mutation Assay ◽

Genotoxicity Testing ◽

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Mouse lymphoma thymidine kinase gene mutation assay: Follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000

Environmental and Molecular Mutagenesis ◽

10.1002/em.10122 ◽

2002 ◽

Vol 40 (4) ◽

pp. 292-299 ◽

Author(s):

Martha M. Moore ◽

Masamitsu Honma ◽

Julie Clements ◽

Karen Harrington-Brock ◽

Takumi Awogi ◽

...

Keyword(s):

Thymidine Kinase ◽

New Orleans ◽

International Workshop ◽

Thymidine Kinase Gene ◽

Test Procedures ◽

Kinase Gene ◽

Mutation Assay ◽

Gene Mutation Assay ◽

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Experimental study of thymidine kinase gene therapy of neuroblastoma in vitro and in vivo

Pediatric Surgery International ◽

10.1007/s00383-003-1019-0 ◽

2003 ◽

Vol 19 (5) ◽

pp. 400-405 ◽

Author(s):

Xun Bi ◽

Jing-Zhe Zhang

Keyword(s):

Gene Therapy ◽

Experimental Study ◽

Thymidine Kinase ◽

Thymidine Kinase Gene ◽

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Determination of DNA damage after exposure to inhalation anesthetics in human peripheral lymphocytes and sperm cells in vitro by comet assay

Human & Experimental Toxicology ◽

10.1177/0960327112446818 ◽

2012 ◽

Vol 31 (12) ◽

pp. 1207-1213 ◽

Author(s):

C Kaymak ◽

E Kadioglu ◽

E Coskun ◽

H Basar ◽

M Basar

Keyword(s):

Comet Assay ◽

Sperm Cells ◽

Inhalation Anesthetics ◽

Peripheral Lymphocytes ◽

Human Peripheral Lymphocytes

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Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene

10.1787/9789264242241-en ◽

2015 ◽

Author(s):

Keyword(s):

Thymidine Kinase ◽

Gene Mutation ◽

Mammalian Cell ◽

Thymidine Kinase Gene ◽

Kinase Gene ◽

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Study of oxidative DNA damage in TK6 human lymphoblastoid cells by use of the in vitro micronucleus test: Determination of No-Observed-Effect Levels

Mutation Research/Genetic Toxicology and Environmental Mutagenesis ◽

10.1016/j.mrgentox.2009.06.006 ◽

2009 ◽

Vol 678 (1) ◽

pp. 30-37 ◽

Author(s):

Anne Platel ◽

Fabrice Nesslany ◽

Véronique Gervais ◽

Daniel Marzin

Keyword(s):

Oxidative Dna Damage ◽

Micronucleus Test ◽

Lymphoblastoid Cells ◽

Test Determination

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Combination of adenovirus-mediated thymidine kinase gene therapy with cytotoxic chemotherapy in bladder cancer in vitro

Urologic Oncology Seminars and Original Investigations ◽

10.1016/s1078-1439(02)00241-7 ◽

2003 ◽

Vol 21 (3) ◽

pp. 197-205 ◽

Author(s):

C.T.F. Freund ◽

X.-W. Tong ◽

D. Rowley ◽

D. Engehausen ◽

A. Frolov ◽

...

Keyword(s):

Gene Therapy ◽

Bladder Cancer ◽

Thymidine Kinase ◽

Cytotoxic Chemotherapy ◽

Thymidine Kinase Gene ◽

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Streptococcus gordonii Strains Resistant to Fluorodeoxyuridine Contain Mutations in the Thymidine Kinase Gene and Are Deficient in Thymidine Kinase Activity

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.44.3.787-789.2000 ◽

2000 ◽

Vol 44 (3) ◽

pp. 787-789 ◽

Author(s):

C. A. Franke ◽

T. M. Bolman ◽

S. A. Ottum ◽

K. F. Jones ◽

D. E. Hruby

Keyword(s):

Thymidine Kinase ◽

Kinase Activity ◽

In Vitro Translation ◽

Streptococcus Gordonii ◽

Thymidine Kinase Gene ◽

Thymidine Kinase Activity ◽

Kinase Gene ◽

Reading Frame ◽

ABSTRACT Mutants of Streptococcus gordonii resistant to 5-fluorodeoxyuridine (FUdRr) were isolated. Each strain contained a point mutation resulting in the premature termination of the thymidine kinase (TK) open reading frame (tdk). In vitro translation of the mutant tdkcoding regions resulted in synthesis of truncated TK polypeptides deficient in TK activity.

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