Impact of intrathecal IgG synthesis on neurological disability in patients with multiple sclerosis

2020 ◽  
Vol 45 ◽  
pp. 102382
Author(s):  
Tetsuya Akaishi ◽  
Toshiyuki Takahashi ◽  
Kazuo Fujihara ◽  
Tatsuro Misu ◽  
Shuhei Nishiyama ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neurological Disability ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis

Blood-CSF barrier permselectivity and measurement of intrathecal IgG synthesis in multiple sclerosis

1984 ◽  
pp. 441-447
Author(s):  
P. Livrea ◽  
I. L. Simone ◽  
M. Trojano ◽  
G. B. Zimatore ◽  
R. Pisicchio ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis

scholarly journals Clinically Isolated Syndrome According to McDonald 2010: Intrathecal IgG Synthesis Still Predictive for Conversion to Multiple Sclerosis

2017 ◽  
Vol 18 (10) ◽  
pp. 2061 ◽  
Author(s):  
Philipp Schwenkenbecher ◽  
Anastasia Sarikidi ◽  
Lena Bönig ◽  
Ulrich Wurster ◽  
Paul Bronzlik ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinically Isolated Syndrome ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis

MRZH reaction increases sensitivity for intrathecal IgG synthesis in IgG Oligoclonal band negative Multiple Sclerosis patients

2016 ◽  
Vol 300 ◽  
pp. 30-35 ◽  
Author(s):  
Rafael P C Dias-Carneiro ◽  
Felipe von Glehn ◽  
Adriel S Moraes ◽  
Vinícius O Boldrini ◽  
Alfredo Damasceno ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Oligoclonal Band ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis ◽  
Multiple Sclerosis Patients

Detection of oligoclonal bands as a part of the diagnosis of multiple sclerosis – case studies

2021 ◽  
Vol 57 (2) ◽  
pp. 1-8
Author(s):  
Jolanta Stacherzak-Pawlik ◽  
Paulina Boćko ◽  
Ewa Zagocka
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Autoimmune Diseases ◽  
Oligoclonal Bands ◽  
Multiple Sclerosis Case ◽  
Limit Values ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis ◽  
Specific Antigens

Introduction: Oligoclonal bands are the result of the synthesis of antibodies of limited heterogeneity, that is, directed against one or more specific antigens. Their detection is an important element in the diagnosis of autoimmune diseases. In multiple sclerosis, the diagnostic sensitivity of the determination of oligoclonal bands is high. Aim: The aim of this study is to answer the question whether the detection of oligoclonal bands a more valuable study is than the Tibbling-Link index and reibergram analysis in the context of the diagnosis of multiple sclerosis. Material and methods: Oligoclonal bands were tested in the cerebrospinal fluid and serum from 9 patients suspected of multiple sclerosis using the Sebia HYDRAGEL 3 CSF ISOFOCUSING kit. Results: In 7 out of 9 patients the Tibbling-Link index, reibergram analysis and oligoclonal bands detection clearly indicated intrathecal IgG synthesis. In 2 of 9 patients, detection of oligoclonal bands indicated intrathecal IgG synthesis and the value of Tibbling-Link index and reibergram analysis did not indicated intrathecal IgG production or these tests indicated limit values. Conclusions: The detection of oligoclonal bands in many cases allows for faster diagnosis and introduction of therapy. This test should be an integral part of SM diagnostics.

Intrathecal synthesis of IgM measured after a first demyelinating event suggestive of multiple sclerosis is associated with subsequent MRI brain lesion accrual

2011 ◽  
Vol 18 (5) ◽  
pp. 587-591 ◽  
Author(s):  
Laurence Durante ◽  
Wafaa Zaaraoui ◽  
Audrey Rico ◽  
Lydie Crespy ◽  
Delphine Wybrecht ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Longitudinal Study ◽  
Brain Lesion ◽  
Rank Correlation ◽  
Brain Lesions ◽  
Subsequent Formation ◽  
Intrathecal Synthesis ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis

Background: Previous studies have demonstrated that intrathecal synthesis of IgM is observed in multiple sclerosis (MS) and correlates with a worse disease course. These results suggest that IgM participates in the formation of MS lesions. Objective: The aim of the present study was to assess the potential association between the level of intrathecal synthesis of IgM measured after a clinically isolated syndrome (CIS) and the subsequent formation of brain lesions. Methods: Fifty seven patients with a CIS and a high risk developing MS were enrolled in a longitudinal study. Examination of cerebrospinal fluid was performed after the CIS and included measures of intrathecal IgM and IgG synthesis. Patients were assessed with the same 1.5 Tesla magnetic resonance imaging (MRI) system at baseline and after a mean follow-up period of 49 months (range 36–60). Spearman Rank correlation was used to assess the potential correlations between levels of intrathecal immunoglobulin synthesis and MRI data. Results: The level of intrathecal IgM synthesis was correlated with the number of gadolinium-enhancing lesions at baseline ( p = 0.01) and with accrual of brain lesions during the follow-up period ( p = 0.02). By taking into account brain sub-regions, we demonstrated that the level of intrathecal IgM synthesis was only correlated with the increased number of lesions in the periventricular regions ( p = 0.004). The level of intrathecal IgG synthesis was not correlated with any MRI data. Conclusion: The present longitudinal study demonstrates that the level of intrathecal IgM synthesis measured after a CIS is associated with subsequent lesion accrual during the first years of MS. This result emphasizes the involvement of IgM in plaque formation.

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