Intrathecal IgG synthesis in multiple sclerosis and other neurological diseases: A comparative evaluation by IgG-index and isoelectric focusing

1979 ◽  
Vol 221 (4) ◽  
pp. 245-255 ◽  
Author(s):  
M. Poloni ◽  
B. Rocchelli ◽  
R. Scelsi ◽  
P. Pinelli
Keyword(s):  
Multiple Sclerosis ◽  
Isoelectric Focusing ◽  
Comparative Evaluation ◽  
Neurological Diseases ◽  
Igg Synthesis ◽  
Igg Index ◽  
Intrathecal Igg Synthesis

Gel Isoelectric Focusing and IgG Index for Demonstration of Intrathecal IgG Synthesis in Neurological Disorders

1981 ◽  
Vol 18 (3) ◽  
pp. 153-157 ◽  
Author(s):  
Frank A J T M Van Bergh ◽  
Raymund A C Roos
Keyword(s):  
Isoelectric Focusing ◽  
Neurological Diseases ◽  
Oligoclonal Bands ◽  
Immune Reactivity ◽  
Igg Synthesis ◽  
Immunochemical Quantitation ◽  
Igg Index ◽  
Intrathecal Igg Synthesis ◽  
The Central Nervous System ◽  
Gel Isoelectric Focusing

Cerebrospinal fluid (CSF) and serum were obtained from 37 patients with multiple sclerosis and from 112 patients with various other neurological diseases, and the concentrations of IgG and albumin were quantitated immunochemically. Simultaneously, isoelectric focusing (IF) was carried out for the detection of CSF-specific oligoclonal bands in the alkaline region. CSF-specific components were found in 51 patients by IF, the estimated number of which correlated significantly (Rs = 0·733, p<0·0001) with the value of the IgG index. In addition, six patients without CSF-specific abnormalities on IF had an increased IgG index (>0·70). In two of them this increase is, in all probability, false-positive; three others showed fully identical IF bands in both CSF and serum. On the other hand, 13 of the same 51 patients showed a normal IgG index (<0·70) although CSF-specific components were detectable on IF. These results confirm the superiority of IF over the immunochemical quantitation of albumin and total IgG for the evaluation of immune reactivity in the central nervous system.

scholarly journals Intrathecal kappa free light chains as markers for multiple sclerosis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
D. Vecchio ◽  
G. Bellomo ◽  
R. Serino ◽  
E. Virgilio ◽  
M. Lamonaca ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Light Chain ◽  
Neurological Diseases ◽  
High Sensitivity ◽  
Free Light Chain ◽  
Prognostic Impact ◽  
Free Light Chains ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis ◽  
Reliable Marker

AbstractCerebrospinal fluid (CSF) kappa free light chain (KFLC) index has been described as a reliable marker of intrathecal IgG synthesis to diagnose multiple sclerosis (MS). Our aims were: (1) to compare the efficiency of KFLC through different interpretation approaches in diagnosing MS. (2) to evaluate the prognostic value of KFLC in radiologically and clinically isolated syndromes (RIS-CIS). We enrolled 133 MS patients and 240 with other neurological diseases (93 inflammatory including 18 RIS-CIS, 147 non-inflammatory). Albumin, lambda free light chain (LFLC) and KFLC were measured in the CSF and serum by nephelometry. We included two groups of markers: (a) corrected for blood-CSF barrier permeability: immunoglobulin G (IgG), KFLC and LFLC indexes. (b) CSF ratios (not including albumin and serum-correction): CSF KFLC/LFLC, CSF KFLC/IgG, CSF LFLC/IgG. KFLC were significantly higher in MS patients compared to those with other diseases (both inflammatory or not). KFLC index and CSF KFLC/IgG ratio showed high sensitivity (93% and 86.5%) and moderate specificity (85% and 88%) in diagnosing MS. RIS-CIS patients who converted to MS showed greater KFLC index and CSF KFLC/IgG. Despite OB are confirmed to be the gold-standard to detect intrathecal IgG synthesis, the KFLC confirmed their accuracy in MS diagnosis. A “kappa-oriented” response characterizes MS and has a prognostic impact in the RIS-CIS population.

Intrathecal IgG synthesis in multiple sclerosis: Comparison between isoelectric focusing and quantitative estimation of cerebrospinal fluid IgG

1981 ◽  
Vol 224 (3) ◽  
pp. 159-169 ◽  
Author(s):  
P. Livrea ◽  
M. Trojano ◽  
I. L. Simone ◽  
G. B. Zimatore ◽  
G. Lamontanara ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Isoelectric Focusing ◽  
Quantitative Estimation ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis

Intrathecal IgG Synthesis in Multiple Sclerosis: Correlation with Clinical Parameters

1988 ◽  
pp. 21-31
Author(s):  
P. Livrea ◽  
I. L. Simone ◽  
M. Trojano ◽  
L. Pisicchio ◽  
G. Logroscino ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Parameters ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis

Blood-CSF barrier permselectivity and measurement of intrathecal IgG synthesis in multiple sclerosis

1984 ◽  
pp. 441-447
Author(s):  
P. Livrea ◽  
I. L. Simone ◽  
M. Trojano ◽  
G. B. Zimatore ◽  
R. Pisicchio ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis

Impact of intrathecal IgG synthesis on neurological disability in patients with multiple sclerosis

2020 ◽  
Vol 45 ◽  
pp. 102382
Author(s):  
Tetsuya Akaishi ◽  
Toshiyuki Takahashi ◽  
Kazuo Fujihara ◽  
Tatsuro Misu ◽  
Shuhei Nishiyama ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neurological Disability ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis

scholarly journals Clinically Isolated Syndrome According to McDonald 2010: Intrathecal IgG Synthesis Still Predictive for Conversion to Multiple Sclerosis

2017 ◽  
Vol 18 (10) ◽  
pp. 2061 ◽  
Author(s):  
Philipp Schwenkenbecher ◽  
Anastasia Sarikidi ◽  
Lena Bönig ◽  
Ulrich Wurster ◽  
Paul Bronzlik ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinically Isolated Syndrome ◽  
Igg Synthesis ◽  
Intrathecal Igg Synthesis
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