Investigation of emulsified, acid and acid-alkali catalyzed mesoporous bioactive glass microspheres for bone regeneration and drug delivery

2013 ◽  
Vol 33 (7) ◽  
pp. 4236-4243 ◽  
Author(s):  
Guohou Miao ◽  
Xiaofeng Chen ◽  
Hua Dong ◽  
Liming Fang ◽  
Cong Mao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Glass Microspheres ◽  
Mesoporous Bioactive Glass

scholarly journals Magnetic mesoporous bioactive glass for synergetic use in bone regeneration, hyperthermia treatment, and controlled drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (36) ◽  
pp. 21413-21419 ◽  
Author(s):  
Muhammad Saif Ur Rahman ◽  
Muhammad Asif Tahir ◽  
Saima Noreen ◽  
Muhammad Yasir ◽  
Ijaz Ahmad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Controlled Drug Delivery ◽  
Hyperthermia Treatment ◽  
Mesoporous Bioactive Glass

A combination of chemotherapy with hyperthermia can produce remarkable success in treating advanced cancers.

An emulsification–solvent evaporation route to mesoporous bioactive glass microspheres for bisphosphonate drug delivery

2011 ◽  
Vol 47 (5) ◽  
pp. 2256-2263 ◽  
Author(s):  
Min Zhu ◽  
Jianlin Shi ◽  
Qianjun He ◽  
Lingxia Zhang ◽  
Feng Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Solvent Evaporation ◽  
Glass Microspheres ◽  
Emulsification Solvent Evaporation ◽  
Mesoporous Bioactive Glass

scholarly journals In Vivo Validation of Spray-Dried Mesoporous Bioactive Glass Microspheres Acting as Prolonged Local Release Systems for BMP-2 to Support Bone Regeneration

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 823
Author(s):  
Julia C. Berkmann ◽  
Aaron X. Herrera Martin ◽  
Carlotta Pontremoli ◽  
Kai Zheng ◽  
Christian H. Bucher ◽  
...  
Keyword(s):  
Growth Factor ◽  
Side Effects ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Low Dose ◽  
Bone Morphogenetic Protein 2 ◽  
Burst Release ◽  
Glass Microspheres ◽  
Osteogenic Response ◽  
Mesoporous Bioactive Glass

Bone morphogenetic protein-2 (BMP-2) is a known key mediator of physiological bone regeneration and is clinically approved for selected musculoskeletal interventions. Yet, broad usage of this growth factor is impeded due to side effects that are majorly evoked by high dosages and burst release kinetics. In this study, mesoporous bioactive glass microspheres (MBGs), produced by an aerosol-assisted spray-drying scalable process, were loaded with BMP-2 resulting in prolonged, low-dose BMP-2 release without affecting the material characteristics. In vitro, MBGs were found to be cytocompatible and to induce a pro-osteogenic response in primary human mesenchymal stromal cells (MSCs). In a pre-clinical rodent model, BMP-2 loaded MBGs significantly enhanced bone formation and influenced the microarchitecture of newly formed bone. The MBG carriers alone performed equal to the untreated (empty) control in most parameters tested, while additionally exerting mild pro-angiogenic effects. Using MBGs as a biocompatible, pro-regenerative carrier for local and sustained low dose BMP-2 release could limit side effects, thus enabling a safer usage of BMP-2 as a potent pro-osteogenic growth factor.

scholarly journals Correction: Magnetic mesoporous bioactive glass for synergetic use in bone regeneration, hyperthermia treatment, and controlled drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (41) ◽  
pp. 24242-24242
Author(s):  
Muhammad Saif Ur Rahman ◽  
Muhammad Asif Tahir ◽  
Saima Noreen ◽  
Muhammad Yasir ◽  
Ijaz Ahmad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Controlled Drug Delivery ◽  
Hyperthermia Treatment ◽  
Mesoporous Bioactive Glass

Correction for ‘Magnetic mesoporous bioactive glass for synergetic use in bone regeneration, hyperthermia treatment, and controlled drug delivery’ by Muhammad Saif Ur Rahman et al., RSC Adv., 2020, 10, 21413–21419, DOI: 10.1039/C9RA09349D.

scholarly journals In vivo validation of spray-dried mesoporous bioactive glass microspheres acting as prolonged local release systems for BMP-2 to induce bone regeneration

2020 ◽  
Author(s):  
Julia C. Berkmann ◽  
Aaron X. Herrera Martin ◽  
Carlotta Pontremoli ◽  
Kai Zheng ◽  
Christian H. Bucher ◽  
...  
Keyword(s):  
Growth Factor ◽  
Side Effects ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Low Dose ◽  
Burst Release ◽  
Human Mscs ◽  
Glass Microspheres ◽  
Osteogenic Response ◽  
Mesoporous Bioactive Glass

AbstractDespite years of diligent research in fracture healing, an unmet clinical need for safe and effective pharmacological treatments to improve bone regeneration persists with 10 – 20 % of fracture cases exhibiting impaired healing. Bone morphogenetic protein-2 (BMP-2) is a known key mediator of physiological bone regeneration and is clinically approved for selected musculoskeletal interventions. Yet, broad usage of this growth factor is impeded due to side effects that are majorly evoked by high dosages and burst release kinetics.In this study, mesoporous bioactive glass microspheres (MBGs) produced by an aerosol assisted spray-drying, scalable process were found to be biocompatible and to induce a pro-osteogenic response on human MSCs in vitro. Loading of the MBGs with BMP-2 resulted in prolonged, low-dose BMP-2 release without affecting the material features. In a pre-clinical rodent model, BMP-2 loaded MBGs significantly enhanced bone formation and influenced the microarchitecture of newly formed bone. The MBG carriers alone performed equal to the untreated (empty) control in most parameters tested, while additionally exerting mild pro-angiogenic effects.Using MBGs as a biocompatible, pro-regenerative carrier for local and sustained low dose BMP-2 release could limit side effects, thus enabling a safer usage of BMP-2 as a potent pro-osteogenic growth factor.

scholarly journals Mesoporous bioactive glass/ɛ-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep

2019 ◽  
Vol 90 ◽  
pp. 393-402 ◽  
Author(s):  
N. Gómez-Cerezo ◽  
L. Casarrubios ◽  
M. Saiz-Pardo ◽  
L. Ortega ◽  
D. de Pablo ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Regeneration ◽  
Mesoporous Bioactive Glass

Mesoporous bioactive glass as a drug delivery system: fabrication, bactericidal properties and biocompatibility

2013 ◽  
Vol 24 (8) ◽  
pp. 1951-1961 ◽  
Author(s):  
Yang Li ◽  
Yi-Zhuo Liu ◽  
Teng Long ◽  
Xi-Bin Yu ◽  
Ting–Ting Tang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bioactive Glass ◽  
Drug Delivery System ◽  
Delivery System ◽  
Bactericidal Properties ◽  
Mesoporous Bioactive Glass

Surfactant-assisted sol–gel synthesis of mesoporous bioactive glass microspheres

2019 ◽  
Vol 8 (2) ◽  
pp. 126-134
Author(s):  
Fabian Zemke ◽  
Valerie Schölch ◽  
Maged F Bekheet ◽  
Franziska Schmidt
Keyword(s):  
Bioactive Glass ◽  
Sol Gel ◽  
Glass Microspheres ◽  
Sol Gel Synthesis ◽  
Surfactant Assisted ◽  
Mesoporous Bioactive Glass
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