In vivo drug delivery of gemcitabine with PEGylated single-walled carbon nanotubes

2016 ◽  
Vol 62 ◽  
pp. 614-625 ◽  
Author(s):  
Ali Razzazan ◽  
Fatemeh Atyabi ◽  
Bahram Kazemi ◽  
Rassoul Dinarvand
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

scholarly journals Single-Walled Carbon Nanotubes Mediated Neovascularity Targeted Antitumor Drug Delivery System

2013 ◽  
Vol 16 (1) ◽  
pp. 40 ◽  
Author(s):  
Chengqun Chen ◽  
Huijuan Zhang ◽  
Lin Hou ◽  
Jinjin Shi ◽  
Lei Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Single Walled Carbon Nanotubes ◽  
Antitumor Drug ◽  
Mice Model ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Purpose. The aim of this study was to prepare a new neovascularity targeting antitumor drug delivery system mediated by single-walled carbon nanotubes (SWNTs). Methods. In this study, antiangiogenesis agent 2-methoxyestradiol was loaded by SWNTs via π~π accumulation. The SWNTs were then linked with NGR (Asn-Gly-Arg) peptide, which could target tumor angiogenesis. This drug delivery system was characterized by transmission electron microscope, scanning electron microscopy, and atomic force microscope analysis. The suppression efficacy of tumor growth in cultured breast cancer cell line was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The in vivo antitumor activity was evaluated on the Sarcoma (S180) tumor-bearing mice model. Results. The characteristics of this drug delivery system showed that the particle of complex was 190 ± 4.3 nm in size distribution and 23.56 ± 2.03 mV in zeta potential. The inhibition ratio of this SWNTs drug delivery system at 24, 48, and 72 h was about 57.7%, 83.6%, and 88.2%. Compared with normal saline group, the relative tumor volumes in the 2ME, SWNTs-2ME, and NGR-SWNTs-2ME groups were decreased 1 week after administration. Conclusion. This novel neovascularity targeting drug delivery system containing NGR-SWNTs-2ME may be beneficial to improve treatment efficacy and minimize side effects in future cancer therapy. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

Single-Walled Carbon Nanotubes Noncovalently Functionalized with Lipid Modified Polyethylenimine for siRNA Delivery in Vitro and in Vivo

2014 ◽  
Vol 25 (10) ◽  
pp. 1744-1751 ◽  
Author(s):  
King S. Siu ◽  
Xiufen Zheng ◽  
Yanling Liu ◽  
Yujuan Zhang ◽  
Xusheng Zhang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Sirna Delivery ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

scholarly journals Correction: Phosphatidylserine Targets Single-Walled Carbon Nanotubes to Professional Phagocytes In Vitro and In Vivo

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
Author(s):  
Nagarjun V. Konduru ◽  
Yulia Y. Tyurina ◽  
Weihong Feng ◽  
Liana V. Basova ◽  
Natalia A. Belikova ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

scholarly journals In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes

2013 ◽  
Vol 8 (11) ◽  
pp. 873-880 ◽  
Author(s):  
Nicole M. Iverson ◽  
Paul W. Barone ◽  
Mia Shandell ◽  
Laura J. Trudel ◽  
Selda Sen ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Near Infrared ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

In Vivo Behavior of Large Doses of Ultrashort and Full-Length Single-Walled Carbon Nanotubes after Oral and Intraperitoneal Administration to Swiss Mice

ACS Nano ◽  
2010 ◽  
Vol 4 (3) ◽  
pp. 1481-1492 ◽  
Author(s):  
Jelena Kolosnjaj-Tabi ◽  
Keith B. Hartman ◽  
Sabah Boudjemaa ◽  
Jeyarama S. Ananta ◽  
Georges Morgant ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Intraperitoneal Administration ◽  
Single Walled Carbon Nanotubes ◽  
Full Length ◽  
Single Walled Carbon ◽  
Swiss Mice ◽  
Walled Carbon Nanotubes

scholarly journals Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cells

Gene Therapy ◽  
2006 ◽  
Vol 13 (24) ◽  
pp. 1714-1723 ◽  
Author(s):  
R Yang ◽  
X Yang ◽  
Z Zhang ◽  
Y Zhang ◽  
S Wang ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Antigen Presenting Cells ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Antigen Presenting ◽  
Walled Carbon Nanotubes
Sign in / Sign up

Export Citation Format

Share Document