scholarly journals Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 111
Author(s):  
Gordana Stanojević ◽  
Djordje Medarević ◽  
Ivana Adamov ◽  
Nikola Pešić ◽  
Jovana Kovačević ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Release Rate ◽  
Drug Loading ◽  
Prolonged Release ◽  
Cylindrical Shape ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
3D Printed ◽  
Artificial Neural ◽  
Poly Ethylene

Various three-dimensional printing (3DP) technologies have been investigated so far in relation to their potential to produce customizable medicines and medical devices. The aim of this study was to examine the possibility of tailoring drug release rates from immediate to prolonged release by varying the tablet thickness and the drug loading, as well as to develop artificial neural network (ANN) predictive models for atomoxetine (ATH) release rate from DLP 3D-printed tablets. Photoreactive mixtures were comprised of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 in a constant ratio of 3:1, water, photoinitiator and ATH as a model drug whose content was varied from 5% to 20% (w/w). Designed 3D models of cylindrical shape tablets were of constant diameter, but different thickness. A series of tablets with doses ranging from 2.06 mg to 37.48 mg, exhibiting immediate- and modified-release profiles were successfully fabricated, confirming the potential of this technology in manufacturing dosage forms on demand, with the possibility to adjust the dose and release behavior by varying drug loading and dimensions of tablets. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and microscopic analysis showed that ATH remained in a crystalline form in tablets, while FTIR spectroscopy confirmed that no interactions occurred between ATH and polymers.

Clickable PEG hydrogel microspheres as building blocks for 3D bioprinting

2019 ◽  
Vol 7 (3) ◽  
pp. 1179-1187 ◽  
Author(s):  
Shangjing Xin ◽  
David Chimene ◽  
Jay E. Garza ◽  
Akhilesh K. Gaharwar ◽  
Daniel L. Alge
Keyword(s):  
Ethylene Glycol ◽  
Building Blocks ◽  
3D Bioprinting ◽  
Complex Cell ◽  
Poly Ethylene Glycol ◽  
3D Printed ◽  
Poly Ethylene ◽  
Hydrogel Microspheres

Clickable poly(ethylene glycol) hydrogel microspheres can be 3D printed and photochemically annealed to produce complex cell-laden structures.

scholarly journals A Non-Cytotoxic Resin for Micro-Stereolithography for Cell Cultures of HUVECs

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 246 ◽  
Author(s):  
Max Männel ◽  
Carolin Fischer ◽  
Julian Thiele
Keyword(s):  
Cell Culture ◽  
Ethylene Glycol ◽  
Umbilical Vein ◽  
Polymer Materials ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
3D Printed ◽  
Poly Ethylene ◽  
The Impact

Three-dimensional (3D) printing of microfluidic devices continuously replaces conventional fabrication methods. A versatile tool for achieving microscopic feature sizes and short process times is micro-stereolithography (µSL). However, common resins for µSL lack biocompatibility and are cytotoxic. This work focuses on developing new photo-curable resins as a basis for µSL fabrication of polymer materials and surfaces for cell culture. Different acrylate- and methacrylate-based compositions are screened for material characteristics including wettability, surface roughness, and swelling behavior. For further understanding, the impact of photo-absorber and photo-initiator on the cytotoxicity of 3D-printed substrates is studied. Cell culture experiments with human umbilical vein endothelial cells (HUVECs) in standard polystyrene vessels are compared to 3D-printed parts made from our library of homemade resins. Among these, after optimizing material composition and post-processing, we identify selected mixtures of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) methyl ethyl methacrylate (PEGMEMA) as most suitable to allow for fabricating cell culture platforms that retain both the viability and proliferation of HUVECs. Next, our PEGDA/PEGMEMA resins will be further optimized regarding minimal feature size and cell adhesion to fabricate microscopic (microfluidic) cell culture platforms, e.g., for studying vascularization of HUVECs in vitro.

scholarly journals Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 195 ◽  
Author(s):  
Catalina Paula Spatarelu ◽  
Anita-Laura (Radu) Chiriac ◽  
Bogdan Cursaru ◽  
Tanta-Verona Iordache ◽  
Ana-Mihaela Gavrila ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Natural Zeolite ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Preparation Conditions ◽  
Transmission Electron ◽  
Poly Ethylene

This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

scholarly journals Enhanced user-control of small molecule drug release from a poly(ethylene glycol) hydrogel via azobenzene/cyclodextrin complex tethers

2016 ◽  
Vol 4 (6) ◽  
pp. 1035-1039 ◽  
Author(s):  
Eric M. Nehls ◽  
Adrianne M. Rosales ◽  
Kristi S. Anseth
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Small Molecule ◽  
Release Rate ◽  
Poly Ethylene Glycol ◽  
Small Peptide ◽  
Cyclodextrin Complex ◽  
Small Molecule Drug ◽  
Poly Ethylene ◽  
Host Chemistry

Photoresponsive azobenzene–cyclodextrin guest–host chemistry can be used to control the release rate of a small peptide from a PEG hydrogel with light.

Mechanical properties and hydrolytic degradation of methoxy poly(ethylene glycol)-b-poly(DL-lactide-coglycolide- co-ε-caprolactone) diblock copolymer films

e-Polymers ◽  
2008 ◽  
Vol 8 (1) ◽  
Author(s):  
Nongnit Morakot ◽  
Jirasak Threeprom ◽  
Yodthong Baimark
Keyword(s):  
Mechanical Properties ◽  
Weight Loss ◽  
Ethylene Glycol ◽  
Diblock Copolymers ◽  
Hydrolytic Degradation ◽  
Size Exclusion ◽  
Block Length ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
Poly Ethylene

AbstractBiodegradable films of methoxy poly(ethylene glycol)-b-poly(DL-lactideco- glycolide-co-ε-caprolactone) diblock copolymers (MPEG-b-PDLLGCL) were prepared by solution casting method. Effects of MPEG block length and DLL:G:CL ratio of the MPEG-b-PDLLGCL films on their mechanical properties and hydrolytic degradation were studied and discussed. It was found that the mechanical properties of films were strongly dependent on glass transition temperatures (Tg) of the diblock copolymers. The hydrolytic degradation was investigated in phosphatebuffered solution at 37°C. The degraded films were characterized using gravimetry (%water uptake and %weight loss), 1H-NMR spectroscopy, differential scanning calorimetry and size exclusion chromatography. The %weight loss of the degraded films increased and molecular weight decreased on increasing the MPEG block length and incorporating the G and CL units, according to their %water uptakes. The MPEG content of the degraded film decreased and the Tg increased with hydrolytic degradation time.

scholarly journals Polymer Electrolytes Based on Borane/Poly(ethylene glycol) Methyl Ether for Lithium Batteries

2017 ◽  
Vol 2017 ◽  
pp. 1-6
Author(s):  
Ali Murat Soydan ◽  
Recep Akdeniz
Keyword(s):  
Ethylene Glycol ◽  
Methyl Ether ◽  
Polymer Electrolytes ◽  
Lithium Ion ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
Molar Ratios ◽  
Poly Ethylene ◽  
Chain Lengths ◽  
Glycol Methyl Ether

This work presents a different approach to preparing polymer electrolytes having borate ester groups for lithium ion batteries. The polymers were synthesized by reaction between poly(ethylene glycol) methyl ether (PEGME) and BH3-THF complex. Molecular weight of PEGMEs was changed with different chain lengths. Then the polymer electrolytes comprising boron were prepared by doping of the matrices with CF3SO3Li at various molar ratios with respect to EO to Li and they are abbreviated as PEGMEX-B-Y. The identification of the PEGME-borate esters was carried out by FTIR and 1H NMR spectroscopy. Thermal properties of these electrolytes were investigated via thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The ionic conductivity of these novel polymer electrolytes was studied by dielectric-impedance spectroscopy. Lithium ion conductivity of these electrolytes was changed by the length of PEGME as well as the doping ratios. They exhibit approximate conductivities of 10−4 S·cm−1 at 30°C and 10−3 S·cm−1 at 100°C.

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