Biomedical applications of natural rubber latex from the rubber tree Hevea brasiliensis

The mucous liquid of Hevea brasiliensis or Para rubber tree, called natural rubber latex (NRL), composes of cis-1,4-polyisoprene which can form a patch under suitable formulation. In this study, blank and 5% lidocaine-loaded NRL patches were formulated and then characterized for physicochemical properties as well as evaluated in vitro drug release and stability. The patches were observed for their appearances. Surface morphology of the patches was investigated using a SEM. XRD was employed to study the crystallinity of the drug, the patch, and the drug-loaded patch. The extractions of lidocaine-loaded patches were analyzed for drug contents by HPLC. In vitro drug release study was performed using modified Franz diffusion cells. The patches at initial preparation and after kept at 4, 25, and 45 °C for 3 months were investigated for the stability determination. The results suggested that NRL could be used as a main component in pharmaceutical transdermal patches with acceptable physicochemical properties. Lidocaine-loaded NRL patches provided desirable drug release but high storage temperatures could age the patches resulting in darken color and lower release amount.

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Absence of cross-reactivity of IgE antibodies from subjects allergic to Hevea brasiliensis latex with a new source of natural rubber latex from guayule (Parthenium argentatum)

Journal of Allergy and Clinical Immunology ◽

10.1016/s0091-6749(96)80005-4 ◽

1996 ◽

Vol 98 (5) ◽

pp. 895-902 ◽

Cited By ~ 59

Author(s):

Deborah J. Siler ◽

Katrina Cornish ◽

Robert G. Hamilton

Keyword(s):

Natural Rubber ◽

Hevea Brasiliensis ◽

Natural Rubber Latex ◽

Cross Reactivity ◽

Parthenium Argentatum ◽

Rubber Latex ◽

Ige Antibodies

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Cross-Reactivity Studies of Gutta-Percha, Gutta-Balata, and Natural Rubber Latex (Hevea brasiliensis)

Journal of Endodontics ◽

10.1097/00004770-200109000-00008 ◽

2001 ◽

Vol 27 (9) ◽

pp. 584-587 ◽

Cited By ~ 13

Author(s):

G COSTA ◽

J JOHNSON ◽

R HAMILTON

Keyword(s):

Natural Rubber ◽

Hevea Brasiliensis ◽

Natural Rubber Latex ◽

Cross Reactivity ◽

Rubber Latex ◽

Gutta Percha

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Allergenicity of Hev b 13, a major esterase allergen in natural rubber latex (Hevea brasiliensis) allergy, does not only depend on its carbohydrate moiety

Molecular Immunology ◽

10.1016/j.molimm.2009.10.027 ◽

2010 ◽

Vol 47 (4) ◽

pp. 871-877 ◽

Cited By ~ 6

Author(s):

Pierre Rougé ◽

Raphaël Culerrier ◽

Marion Campistron ◽

Claude Granier ◽

Françoise Bienvenu ◽

...

Keyword(s):

Natural Rubber ◽

Hevea Brasiliensis ◽

Natural Rubber Latex ◽

Carbohydrate Moiety ◽

Rubber Latex

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Angiogenic properties of natural rubber latex biomembranes and the serum fraction of Hevea brasiliensis

Brazilian Journal of Physics ◽

10.1590/s0103-97332009000500010 ◽

2009 ◽

Vol 39 (3) ◽

pp. 564-569 ◽

Cited By ~ 49

Author(s):

Mariselma Ferreira ◽

Ricardo José Mendonça ◽

Joaquim Coutinho-Netto ◽

Marcelo Mulato

Keyword(s):

Natural Rubber ◽

Hevea Brasiliensis ◽

Natural Rubber Latex ◽

Rubber Latex

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Preparation of composites from natural rubber and oil palm empty fruit bunch cellulose: Effect of cellulose morphology on properties

BioResources ◽

10.15376/biores.14.2.3168-3181 ◽

2019 ◽

Vol 14 (2) ◽

pp. 3168-3181 ◽

Cited By ~ 1

Author(s):

José Antonio Fiorote ◽

Alair Pereira Freire ◽

Dasciana de Sousa Rodrigues ◽

Maria Alice Martins ◽

Larissa Andreani ◽

...

Keyword(s):

Natural Rubber ◽

Oil Palm ◽

Rubber Tree ◽

Natural Rubber Latex ◽

Oil Industry ◽

Cellulose Content ◽

Rubber Latex ◽

Nanostructured Particles ◽

Empty Fruit Bunches ◽

Cellulose Composites

Rubber tree and oil palm are industrial crops cultivated in the same climate and environment. These plants are used to prepare nanocomposites of natural rubber and cellulose from empty fruit bunches, an abundant residue in the palm oil industry. For this study, the cellulose particles were extracted from the bunches and subjected to enzymatic hydrolysis or microfibrillation to produce nanostructured particles. The nanoparticles were blended with natural rubber latex in an aqueous medium, and the mixture was dried. The properties of the nanocomposites were compared to those of pure natural rubber and unprocessed cellulose composites. The mechanical properties of the natural rubber can be modified by the cellulose content and morphology. As a consequence, it is possible to modulate the material properties by changing only the filler morphology. The use of microfibrillated cellulose had stronger reinforcement effects. The thermal properties of natural rubber were not affected by the addition of cellulose.

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