Characterization of Lidocaine Transdermal Patches from Natural Rubber Latex

2013 ◽  
Vol 747 ◽  
pp. 103-106 ◽  
Author(s):  
Prapaporn Boonme ◽  
Hasleena Boontawee ◽  
Wirach Taweepreda ◽  
Wiwat Pichayakorn
Keyword(s):  
Drug Release ◽  
Natural Rubber ◽  
Physicochemical Properties ◽  
Rubber Tree ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Transdermal Patches ◽  
The Stability ◽  
Main Component

The mucous liquid of Hevea brasiliensis or Para rubber tree, called natural rubber latex (NRL), composes of cis-1,4-polyisoprene which can form a patch under suitable formulation. In this study, blank and 5% lidocaine-loaded NRL patches were formulated and then characterized for physicochemical properties as well as evaluated in vitro drug release and stability. The patches were observed for their appearances. Surface morphology of the patches was investigated using a SEM. XRD was employed to study the crystallinity of the drug, the patch, and the drug-loaded patch. The extractions of lidocaine-loaded patches were analyzed for drug contents by HPLC. In vitro drug release study was performed using modified Franz diffusion cells. The patches at initial preparation and after kept at 4, 25, and 45 °C for 3 months were investigated for the stability determination. The results suggested that NRL could be used as a main component in pharmaceutical transdermal patches with acceptable physicochemical properties. Lidocaine-loaded NRL patches provided desirable drug release but high storage temperatures could age the patches resulting in darken color and lower release amount.

Low Protein Natural Rubber Latex - Based Polymer Blends for Transdermal Patches of Mefenamic Acid

2020 ◽  
Vol 859 ◽  
pp. 34-38
Author(s):  
Jirapornchai Suksaeree ◽  
Wiwat Pichayakorn ◽  
Patsakorn Siripornpinyo ◽  
Somruethai Chaiprasit ◽  
Pattwat Maneewattanapinyo
Keyword(s):  
Natural Rubber ◽  
Mefenamic Acid ◽  
Hydroxypropyl Methylcellulose ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Low Protein ◽  
Transdermal Patches ◽  
Crystallization Inhibitor ◽  
Pass Metabolism

Transdermal patches are attraction and acceptance for the patient due to avoid first-pass metabolism, easy to administer and removal, allows rapid termination of treatment if required etc. Low protein natural rubber latex (LPNRL) is a natural polymer that removed the allergic protein from fresh NRL prepared by treatment with proteolytic enzyme and centrifuging process. LPNRL is used for medical skin applications with the non-allergenic product. The objective of this research aimed to prepare the mefenamic acid – loaded transdermal patches made from LPNRL blended with either hydroxypropyl methylcellulose (HPMC) or polyvinyl alcohol (PVA), glycerin and polyvinylpyrrolidone were used as plasticizer and crystallization inhibitor, respectively. The moisture uptake and swelling ratio showed the increment value after either HPMC or PVA was blended in LPNRL because of the increment of their hydrophilicity. These patches showed the homogeneous films that observed by the researcher. The in vitro release showed a faster release rate after either HPMC or PVA was blended in LPNRL. It was concluded that mefenamic acid – loaded transdermal patches could be prepared by using LPNRL blended with either HPMC or PVA as matrix film former could provide an increased and controlled release of the drug. Moreover, it was safe to apply on the skin as did not cause irritation.

Novel membranes from physico-chemically modified deproteinized natural rubber latex: development, characterisation and drug permeation

2018 ◽  
Vol 42 (17) ◽  
pp. 14179-14187
Author(s):  
Janisha Jayadevan ◽  
G. Unnikrishnan
Keyword(s):  
Drug Release ◽  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Rubber Latex ◽  
Drug Permeation ◽  
Chemically Modified ◽  
Blend Membranes ◽  
Deproteinized Natural Rubber

Novel blend membranes from physico-chemically modified deproteinized natural rubber latex for drug release applications.

Silver nanoparticles effect on drug release of metronidazole in natural rubber latex dressing

2021 ◽  
Author(s):  
Matheus Carlos Romeiro Miranda ◽  
Nicola Carlucci Sato ◽  
Giovana Sant’Ana Pegorin Brasil ◽  
Rodolfo Debone Piazza ◽  
Miguel Jafelicci ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Drug Release ◽  
Natural Rubber ◽  
Natural Rubber Latex ◽  
Rubber Latex

scholarly journals Novel Type of Heme-Dependent Oxygenase Catalyzes Oxidative Cleavage of Rubber (Poly-cis-1,4-Isoprene)

2004 ◽  
Vol 70 (12) ◽  
pp. 7388-7395 ◽  
Author(s):  
Reinhard Braaz ◽  
Peter Fischer ◽  
Dieter Jendrossek
Keyword(s):  
Natural Rubber ◽  
High Performance ◽  
Natural Rubber Latex ◽  
Culture Fluid ◽  
Oxidative Cleavage ◽  
Covalent Attachment ◽  
Rubber Latex ◽  
Chromatography Analysis ◽  
Cloned Gene

ABSTRACT An extracellular protein with strong absorption at 406 nm was purified from cell-free culture fluid of latex-grown Xanthomonas sp. strain 35Y. This protein was identical to the gene product of a recently characterized gene cloned from Xanthomonas sp., as revealed by determination of m/z values and sequencing of selected isolated peptides obtained after trypsin fingerprint analysis. The purified protein degraded both natural rubber latex and chemosynthetic poly(cis-1,4-isoprene) in vitro by oxidative cleavage of the double bonds of poly(cis-1,4-isoprene). 12-Oxo-4,8-dimethyltrideca-4,8-diene-1-al (m/z 236) was identified and unequivocally characterized as the major cleavage product, and there was a homologous series of minor metabolites that differed from the major degradation product only in the number of repetitive isoprene units between terminal functions, CHO-CH2— and —CH2-COCH3. An in vitro enzyme assay for oxidative rubber degradation was developed based on high-performance liquid chromatography analysis and spectroscopic detection of product carbonyl functions after derivatization with dinitrophenylhydrazone. Enzymatic cleavage of rubber by the purified protein was strictly dependent on the presence of oxygen; it did not require addition of any soluble cofactors or metal ions and was optimal around pH 7.0 at 40°C. Carbon monoxide and cyanide inhibited the reaction; addition of catalase had no effect, and peroxidase activity could not be detected. The purified protein was specific for natural rubber latex and chemosynthetic poly(cis-1,4-isoprene). Analysis of the amino acid sequence deduced from the cloned gene (roxA [rubber oxygenase]) revealed the presence of two heme-binding motifs (CXXCH) for covalent attachment of heme to the protein. Spectroscopic analysis confirmed the presence of heme, and approximately 2 mol of heme per mol of RoxA was found.

scholarly journals Preparation of composites from natural rubber and oil palm empty fruit bunch cellulose: Effect of cellulose morphology on properties

BioResources ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. 3168-3181 ◽  
Author(s):  
José Antonio Fiorote ◽  
Alair Pereira Freire ◽  
Dasciana de Sousa Rodrigues ◽  
Maria Alice Martins ◽  
Larissa Andreani ◽  
...  
Keyword(s):  
Natural Rubber ◽  
Oil Palm ◽  
Rubber Tree ◽  
Natural Rubber Latex ◽  
Oil Industry ◽  
Cellulose Content ◽  
Rubber Latex ◽  
Nanostructured Particles ◽  
Empty Fruit Bunches ◽  
Cellulose Composites

Rubber tree and oil palm are industrial crops cultivated in the same climate and environment. These plants are used to prepare nanocomposites of natural rubber and cellulose from empty fruit bunches, an abundant residue in the palm oil industry. For this study, the cellulose particles were extracted from the bunches and subjected to enzymatic hydrolysis or microfibrillation to produce nanostructured particles. The nanoparticles were blended with natural rubber latex in an aqueous medium, and the mixture was dried. The properties of the nanocomposites were compared to those of pure natural rubber and unprocessed cellulose composites. The mechanical properties of the natural rubber can be modified by the cellulose content and morphology. As a consequence, it is possible to modulate the material properties by changing only the filler morphology. The use of microfibrillated cellulose had stronger reinforcement effects. The thermal properties of natural rubber were not affected by the addition of cellulose.

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