Surfactant free synthesis of cationic nano-vesicles: A safe triple drug loaded vehicle for the topical treatment of cutaneous leishmaniasis

2021 ◽  
pp. 102490
Author(s):  
Sidra Khalid ◽  
Saad Salman ◽  
Kashif Iqbal ◽  
Fiza ur Rehman ◽  
Iffat Ullah ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Topical Treatment

scholarly journals Topical treatment of experimental cutaneous leishmaniasis in golden hamster (Mesocricetus auratus) with formulations containing pentamidine

2017 ◽  
Vol 47 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Claudia Dantas COMANDOLLI-WYREPKOWSKI ◽  
Iryna GRAFOVA ◽  
Maricleide de Farias NAIFF ◽  
Maurizio AVELLA ◽  
Gennaro GENTILE ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Topical Treatment ◽  
Usnic Acid ◽  
Parasite Burden ◽  
Experimental Treatment ◽  
Mesocricetus Auratus ◽  
Current Treatment ◽  
Tissue Samples ◽  
Golden Hamsters ◽  
Pentamidine Isethionate

ABSTRACT Current treatment of cutaneous leishmaniasis (CL) relies mainly on pentavalent antimonials salts and second-line drugs include pentamidine and amphotericin B, but these therapies have side effects and require parenteral administration. The aim of this work was to evaluate the topical formulations containing pentamidine isethionate (PI) in the experimental treatment of cutaneous leishmaniasis (CL). Golden hamsters (Mesocricetus auratus) were infected in the nose with Leishmania (Leishmania) amazonensis. Six treatment groups received different topical treatments of anhydrous or hydrating emulsions, for a maximum of 10 days, with an application of 50 mg day-1. After treatment tissue samples of lesions were evaluated by histology, transmission electron microscopy and biopsy cultivation. Compared with untreated group, topical treatment with hydrating emulsion with 10% PI and usnic acid (ACE5AU) showed significantly decrease in volume lesion (P= 0.028) on 20th day after the end of the treatment with reduction of 27.37%. Topical treatment with anhydrous emulsion with 10% PI and usnic acid (ACPU) reduces parasite burden in Golden hamsters. This study demonstrated the potential of topical treatment to reduce the number of parasites that could be combined with others drugs and to have a faster and more effective treatment of cutaneous leishmaniasis.

Topical treatment with a two-component gel releasing nitric oxide cures C57BL/6 mice from cutaneous leishmaniasis caused byLeishmania major

2016 ◽  
Vol 25 (11) ◽  
pp. 914-916 ◽  
Author(s):  
Florian Butsch ◽  
Beate Lorenz ◽  
Alfred Goldinger ◽  
Esther von Stebut
Keyword(s):  
Nitric Oxide ◽  
Cutaneous Leishmaniasis ◽  
Topical Treatment ◽  
Two Component

Drug delivery systems for the topical treatment of cutaneous leishmaniasis

2012 ◽  
Vol 9 (9) ◽  
pp. 1083-1097 ◽  
Author(s):  
Guilherme Carneiro ◽  
Marta Gontijo Aguiar ◽  
Ana Paula Fernandes ◽  
Lucas Antônio Miranda Ferreira
Keyword(s):  
Drug Delivery ◽  
Cutaneous Leishmaniasis ◽  
Topical Treatment ◽  
Drug Delivery Systems ◽  
Delivery Systems

Efficacious topical treatment for human cutaneous leishmaniasis with ethanolic lipid amphotericin B

2001 ◽  
Vol 95 (2) ◽  
pp. 184-186 ◽  
Author(s):  
Daniel Vardy ◽  
Yechezkel Barenholz ◽  
Natalia Naftoliev ◽  
Sidney Klaus ◽  
Leon Gilead ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Amphotericin B ◽  
Topical Treatment ◽  
Lipid Amphotericin B ◽  
Human Cutaneous Leishmaniasis

Nanoparticles as multifunctional devices for the topical treatment of cutaneous leishmaniasis

2014 ◽  
Vol 11 (4) ◽  
pp. 579-597 ◽  
Author(s):  
Esther Moreno ◽  
Juana Schwartz ◽  
Celia Fernández ◽  
Carmen Sanmartín ◽  
Paul Nguewa ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Topical Treatment ◽  
Multifunctional Devices

scholarly journals A Functional Wound Dressing as a Potential Treatment for Cutaneous Leishmaniasis

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 200 ◽  
Author(s):  
Francisco Alexandrino-Junior ◽  
Kattya Gyselle de Holanda e Silva ◽  
Marjorie Caroline Liberato Cavalcanti Freire ◽  
Viviane de Oliveira Freitas Lione ◽  
Elisama Azevedo Cardoso ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Topical Treatment ◽  
Healing Process ◽  
Water Vapor Permeability ◽  
Vero Cells ◽  
Poly Vinyl Alcohol ◽  
Vapor Permeability ◽  
Secondary Infections ◽  
Leishmania Spp

Cutaneous leishmaniasis (CL) is a parasitic disease characterized by progressive skin sores. Currently, treatments for CL are limited to parenteral administration of the drug, which presents severe adverse effects and low cure rates. Therefore, this study aimed to develop poly(vinyl-alcohol) (PVA) hydrogels containing Amphotericin B (AmB) intended for topical treatment of CL. Hydrogels were evaluated in vitro for their potential to eliminate promastigote forms of Leishmania spp., to prevent secondary infections, to maintain appropriate healing conditions, and to offer suitable biocompatibility. AmB was incorporated into the system in its non-crystalline state, allowing it to swell more and faster than the system without the drug. Furthermore, the AmB release profile showed a continuous and controlled behavior following Higuchi´s kinetic model. AmB-loaded-PVA-hydrogels (PVA–AmB) also showed efficient antifungal and leishmanicidal activity, no cytotoxic potential for VERO cells, microbial impermeability and water vapor permeability compatible with the healthy skin’s physiological needs. Indeed, these results revealed the potential of PVA–AmB to prevent secondary infections and to maintain a favorable environment for the healing process. Hence, these results suggest that PVA–AmB could be a suitable and efficient new therapeutic approach for the topical treatment of CL.

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