Oxygen-independent free radical generation mediated by core-shell magnetic nanocomposites synergizes with immune checkpoint blockade for effective primary and metastatic tumor treatment

Nano Today ◽  
2021 ◽  
Vol 36 ◽  
pp. 101024
Author(s):  
Jin-Cheng Guo ◽  
Qiao An ◽  
Mengyu Guo ◽  
Yating Xiao ◽  
Bo Li ◽  
...  
Keyword(s):  
Free Radical ◽  
Immune Checkpoint ◽  
Metastatic Tumor ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Magnetic Nanocomposites ◽  
Core Shell ◽  
Tumor Treatment ◽  
Free Radical Generation ◽  
Radical Generation

Magnetothermally Triggered Free-Radical Generation for Deep-Seated Tumor Treatment

Nano Letters ◽  
2021 ◽  
Author(s):  
Guoming Huang ◽  
Yuan Qiu ◽  
Feifei Yang ◽  
Jiangao Xie ◽  
Xin Chen ◽  
...  
Keyword(s):  
Free Radical ◽  
Tumor Treatment ◽  
Free Radical Generation ◽  
Radical Generation

Click Reaction-Assisted Peptide Immune Checkpoint Blockade for Solid Tumor Treatment

2020 ◽  
Vol 12 (36) ◽  
pp. 40042-40051
Author(s):  
Wu-Yi Xiao ◽  
Yi Wang ◽  
Hong-Wei An ◽  
Dayong Hou ◽  
Muhetaerjiang Mamuti ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Immune Checkpoint ◽  
Click Reaction ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Tumor Treatment

Analysis of Advanced Melanomas Changed from Immune Checkpoint Blockade Therapy to Palliative Care

2018 ◽  
Vol 80 (1) ◽  
pp. 51-55
Author(s):  
Ai KAJITA ◽  
Osamu YAMASAKI ◽  
Tatsuya KAJI ◽  
Hiroshi UMEMURA ◽  
Keiji IWATSUKI
Keyword(s):  
Palliative Care ◽  
Immune Checkpoint ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade

Potential immunotherapy for Alzheimer disease and age-related dementia

2019 ◽  
Vol 21 (1) ◽  
pp. 21-25 ◽  
Keyword(s):  
Immune System ◽  
Alzheimer Disease ◽  
Cross Talk ◽  
Immune Checkpoint ◽  
Short Review ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
New Approach ◽  
Age Related ◽  
The Brain

Emerging results support the concept that Alzheimer disease (AD) and age-related dementia are affected by the ability of the immune system to contain the brain's pathology. Accordingly, well-controlled boosting, rather than suppression of systemic immunity, has been suggested as a new approach to modify disease pathology without directly targeting any of the brain's disease hallmarks. Here, we provide a short review of the mechanisms orchestrating the cross-talk between the brain and the immune system. We then discuss how immune checkpoint blockade directed against the PD-1/PD-L1 pathways could be developed as an immunotherapeutic approach to combat this disease using a regimen that will address the needs to combat AD.

Potential immunotherapy for Alzheimer disease and age-related dementia

2019 ◽  
Vol 21 (1) ◽  
pp. 21-25 ◽  
Keyword(s):  
Immune System ◽  
Alzheimer Disease ◽  
Cross Talk ◽  
Immune Checkpoint ◽  
Short Review ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
New Approach ◽  
Age Related ◽  
The Brain

Emerging results support the concept that Alzheimer disease (AD) and age-related dementia are affected by the ability of the immune system to contain the brain’s pathology. Accordingly, well-controlled boosting, rather than suppression of systemic immunity, has been suggested as a new approach to modify disease pathology without directly targeting any of the brain’s disease hallmarks. Here, we provide a short review of the mechanisms orchestrating the cross-talk between the brain and the immune system. We then discuss how immune checkpoint blockade directed against the PD-1/PD-L1 pathways could be developed as an immunotherapeutic approach to combat this disease using a regimen that will address the needs to combat AD.

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